Zobrazeno 1 - 10
of 72
pro vyhledávání: '"Hiroshi Sugiyama"'
Publikováno v:
ChemBioChem. 22:1538-1545
Pyrrole-imidazole (PI) polyamides, which target specific DNA sequences, have been studied as a class of DNA minor-groove-binding molecules. To investigate the potential of compounds for cancer treatment, PI polyamides were conjugated with DNA-alkylat
Autor:
Weiping Zhu, Yangyang Yang, Yufang Xu, Xuhong Qian, Bin Wang, Hiroshi Sugiyama, Masayuki Endo, Rizhao Pan, Ye Tian
Publikováno v:
Soft Matter. 17:1184-1188
A series of short intrinsically disordered polypeptide conjugated oligonucleotides (IDPOCs) were rationally developed and assembled into well-defined nanospheres. The nanospheres exhibited excellent reversible thermoresponsive regulation of their con
Publikováno v:
RSC Chemical Biology
Because of their stable orientations and their minimal interference with native DNA interactions and folding, emissive isomorphic nucleoside analogues are versatile tools for the accurate analysis of DNA structural heterogeneity. Here, we report on a
Publikováno v:
Chemistry – A European Journal. 27:778-784
Stimuli-responsive switching molecules have been widely investigated for the purpose of the mechanical control of biomolecules. Recently developed arylazopyrazole (AAP) shows photoisomerization activity, displaying a faster response to light-induced
Publikováno v:
Chemistry – A European Journal. 26:15282-15289
The nucleosome is one of the most fundamental units involved in gene expression and consequent cell development, differentiation, and expression of cell functions. We report here a method to place reconstituted nucleosomes into a DNA origami frame fo
Publikováno v:
Chemistry – A European Journal. 26:14639-14644
Many types of molecular targeted drugs that inhibit cancer growth by acting on specific molecules have been developed. The runt-related transcription factor (RUNX) family, which induces cancer development by binding to a specific DNA sequence, has at
Autor:
Yutaro Tsubono, Hiroshi Sugiyama, Ganesh N. Pandian, Kaori Hashiya, Takuya Hidaka, Yusuke Kawamoto, Toshikazu Bando
Publikováno v:
J Am Chem Soc
Telomeres are closely associated with cellular senescence and cancer. Although some techniques have been developed to label telomeres in living cells for study of telomere dynamics, few biocompatible near-infrared probes based on synthetic molecules
Publikováno v:
The Journal of Physical Chemistry B. 124:8794-8800
Forster resonance energy transfer (FRET) has been used as a molecular ruler to monitor the distance between or within biomolecules. A distance- and orientation-dependent FRET system can be a more powerful tool to investigate biomolecules because of i
Publikováno v:
ChemBioChem. 21:2912-2915
We used N-methylpyrrole (Py)-N-methylimidazole-(Im) polyamide as an exogenous agent to modulate the formation of DNA assemblies at specific double-stranded sequences. The concept was demonstrated on the hybridization chain reaction that forms linear
Autor:
Hiromune Ando, Tomohiro Nobeyama, Kazuki Shigyou, Hirotaka Nakatsuji, Hiroshi Sugiyama, Naoko Komura, Tsutomu Hamada, Tatsuya Murakami
Publikováno v:
Langmuir. 36:7741-7746
Liquid-ordered (Lo)-phase domains, a cholesterol-rich area on lipid bilayers, have attracted significant attention recently because of their relevance to lipid rafts, the formation/collapse of which is associated with various kinds of information exc