Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Qingzhen Yu"'
Autor:
Jian Rong, Tuo Shao, Xiaofei Zhang, Jun-An Ma, Mikhail Papisov, Yiding Zhang, Genwei Zhang, Zhen Chen, Masayuki Fujinaga, Yihan Shao, Xiaoyun Deng, Daisuke Ogasawara, Lu Wang, Michael A. Schafroth, Ming-Rong Zhang, Akiko Hatori, Qingzhen Yu, Richard Van, Thomas Lee Collier, Hualong Fu, Kuan Hu, Vasily Belov, Benjamin F. Cravatt, Wakana Mori, Pilar Giffenig, Steven H. Liang, Lee Josephson
Publikováno v:
J Med Chem
Dysfunction of monoacylglycerol lipase (MAGL) is associated with several psychopathological disorders, including drug addiction and neurodegenerative diseases. Herein we design, synthesize and evaluate several irreversible fluorine-containing MAGL in
Autor:
Yiding Zhang, Zhen Chen, Ran Cheng, Tuo Shao, Yihan Shao, Qingzhen Yu, Jun-An Ma, Kuan Hu, Xiaoyun Deng, Akiko Hatori, Steven H. Liang, Lee Josephson, Hualong Fu, Kenneth Dahl, Neil Vasdev, Michael A. Schafroth, Masayuki Fujinaga, Lin Xie, Christopher J. Fowler, Shuyin Gu, Thomas Lee Collier, Lu Wang, Benjamin F. Cravatt, Jian Rong, Daisuke Ogasawara, Tomoteru Yamasaki, Bao Liang, Yuancheng Gou, Ming-Rong Zhang, Xiaofei Zhang, Katsushi Kumata, Genwei Zhang, Wakana Mori, Jingjin Chen
Publikováno v:
Journal of Medicinal Chemistry. 62:3336-3353
Monoacylglycerol lipase (MAGL) is a serine hydrolase that degrades 2-arachidonoylglycerol (2-AG) in the endocannabinoid system (eCB). Selective inhibition of MAGL has emerged as a potential therapeutic approach for the treatment of diverse pathologic
Autor:
Gangqiang Wang, Steven H. Liang, Tomoteru Yamasaki, Lu Wang, Shaofa Sun, Xiaofei Zhang, Katsushi Kumata, Kuan Hu, Lee Josephson, Xiaoyun Deng, Qingzhen Yu, Longle Ma, Akiko Hatori, Ming-Rong Zhang, Zhen Chen, Tuo Shao, Yihan Shao
Publikováno v:
ChemMedChem. 14:303-309
Muscarinic acetylcholine receptors (mAChRs) have five distinct subunits (M1 -M5 ) and are involved in the action of the neurotransmitter acetylcholine in the central and peripheral nervous system. Attributed to the promising clinical efficacy of xano
Autor:
Tuo Shao, Masayuki Fujinaga, Qingzhen Yu, Hsiao-Ying Wey, Richard Van, Steven H. Liang, Loredano Pollegioni, Giulia Murtas, Xiaoyun Deng, Yiding Zhang, Kuan Hu, Wakana Mori, Lee Josephson, Ming-Rong Zhang, Zhen Chen, Yihan Shao, Katsushi Kumata, Akiko Hatori, Jian Rong
Selective DAAO inhibitors have demonstrated promising therapeutic effects in clinical studies, including clinically alleviating symptoms of schizophrenic patients and ameliorating cognitive function in Alzheimer’s patients with early phase. Herein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50f2cafeb0cb232c900032be28a0c5fc
http://hdl.handle.net/11383/2109584
http://hdl.handle.net/11383/2109584
Publikováno v:
Tetrahedron. 74:3879-3887
The C–H activation of aryl amide using readily available Pd(OAc)2 in the presence of selectfluor is reported. The highly mono-selective introduction of sp2 hybridized functional groups have been realized. A broad range of aryl-, alkenyl- and keto-a
Autor:
Hsiao-Ying Wey, Jian Rong, April T. Davenport, James B. Daunais, Zhen Chen, Steven H. Liang, Tuo Shao, Yihan Shao, Qingzhen Yu, Xiaoyun Deng, Lee Josephson, Hualong Fu, Wen‐Wei Qiu, Wei Gao, Thomas Lee Collier, Xiaofei Zhang
Publikováno v:
ChemMedChem
Leucin-rich repeat kinase 2 (LRRK2) is a large protein that is involved in the pathogenesis of Parkinson’s disease (PD). It has been demonstrated that LRRK2 mutations mainly confers PD, which bring about increased kinase activity of LRRK2. As a con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::582b12669d0f0c0b9515b5f58da6b66e
https://europepmc.org/articles/PMC6726558/
https://europepmc.org/articles/PMC6726558/
Publikováno v:
Chemical Communications. 54:1125-1128
Strychnofoline is a Strychnos alkaloid that has unique spirooxindole architecture and possesses important anticancer activity. Here, we have, for the first time, reported the enantioselective synthesis of strychnofoline proceeding in only nine steps
Publikováno v:
Chemical Communications. 53:4258-4261
We report our latest discovery of norbornene derivative modulated highly mono-selective ortho-C-H activation alkylation reactions on arenes bearing simple mono-dentate coordinating groups. The reaction features the use of readily available benzamides
Autor:
Tuo Shao, Qingzhen Yu, Yiding Zhang, Gangqiang Wang, Steven H. Liang, Ming-Rong Zhang, Lee Josephson, Shaofa Sun, Kuan Hu, Katsushi Kumata, Wakana Mori, Masayuki Fujinaga, Xiaoyun Deng, Jian Rong, Akiko Hatori, Yihan Shao
Publikováno v:
Tetrahedron Letters. 61:152060
Positive allosteric modulators of muscarinic acetylcholine receptor subtype 4 have been identified as promising activators for the treatment of neurological disorders and neurodegenerative diseases, including schizophrenia, Alzheimer's disease (AD) a
Autor:
Irina A. Pikuleva, Tuo Shao, Zhen Chen, Qingzhen Yu, Yihan Shao, Jiahui Chen, Xiaoyun Deng, Hualong Fu, Steven H. Liang, Jiyun Sun, Natalia Mast, Thomas Lee Collier, Lee Josephson, Jian Rong
Publikováno v:
Bioorg Med Chem Lett
Cholesterol 24-hydroxylase is a monooxygenase encoded by CYP46A1, which is specifically expressed in the brain where it controls cholesterol elimination by producing 24S-hydroxylcholesterol (24-HC) as the major metabolite. Selective blockade of CYP46