Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Andrei Loas"'
Autor:
Chia-Ling Wu, Annika B. Malmberg, Jenna A. Wood, Andrei Loas, Kamela Bellovoda, Eva M. López-Vidal, Carly K. Schissel, Somesh Mohapatra, Bradley L. Pentelute, Rafael Gómez-Bombarelli
Publikováno v:
JACS Au, Vol 1, Iss 11, Pp 2009-2020 (2021)
JACS Au
JACS Au
Therapeutic macromolecules such as proteins and oligonucleotides can be highly efficacious but are often limited to extracellular targets due to the cell's impermeable membrane. Cell-penetrating peptides (CPPs) are able to deliver such macromolecules
Autor:
Andrei Loas, Bradley L. Pentelute, Christopher R. Shugrue, Peng Dai, Suan Lian Tuang, Diomedes Dieppa-Matos, Chi Zhang
Publikováno v:
Chem Commun (Camb)
We report aqueous, site-selective modification of proteins using a reactive peptide interface comprising a nine-residue sequence. This interface is the fastest (second-order rate constant of 152 M(−1) s(−1)) catalyst-free, cysteine-based method f
Publikováno v:
Chemical Science
In-solution affinity selection (AS) of large synthetic peptide libraries affords identification of binders to protein targets through access to an expanded chemical space. Standard affinity selection methods, however, can be time-consuming, low-throu
Autor:
Andrei Loas, Mackenzie Poskus, Bradley L. Pentelute, Somesh Mohapatra, Rafael Gómez-Bombarelli, Nina Hartrampf
Publikováno v:
ACS Central Science
ACS Central Science, Vol 6, Iss 12, Pp 2277-2286 (2020)
ACS Central Science, Vol 6, Iss 12, Pp 2277-2286 (2020)
The chemical synthesis of polypeptides involves stepwise formation of amide bonds on an immobilized solid support. The high yields required for efficient incorporation of each individual amino acid in the growing chain are often impacted by sequence-
Autor:
Heemal H. Dhanjee, Jacob Rodriguez, Muhammad Jbara, Stephen L. Buchwald, Andrei Loas, Bradley L. Pentelute
Publikováno v:
Angew Chem Int Ed Engl
Organometallic reagents enable practical strategies for bioconjugation. Innovations in the design of water-soluble ligands and the enhancement of reaction rates have allowed for chemoselective cross-coupling reactions of peptides and proteins to be c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d40ac80df43e65bff3e7abc6072a28c
https://europepmc.org/articles/PMC8143041/
https://europepmc.org/articles/PMC8143041/
Autor:
Nina Hartrampf, Shunying Liu, Carly K. Schissel, Sarah Antilla, Alexander J. Mijalis, Thomas E. Nielsen, Zachary P. Gates, Amanda E. Cowfer, Andrei Loas, Azin Saebi, Alex J. Callahan, Anthony J. Quartararo, Stephanie Hanna, Mark D. Simon, Mackenzie Poskus, Carsten Jessen, Xiyun Ye, Bradley L. Pentelute
Publikováno v:
chemRxiv
Ribosomes can produce proteins in minutes and are largely constrained to proteinogenic amino acids. Here, we report highly efficient chemistry matched with an automated fast-flow instrument for the direct manufacturing of peptide chains up to 164 ami
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a7189bbf905fb5562ad7278b78357ef
https://hdl.handle.net/1721.1/128762
https://hdl.handle.net/1721.1/128762
Autor:
Hemantbhai H. Patel, Marius Pelmuş, Erik N. Carrión, Sergiu M. Gorun, Andrei Loas, Karpagavalli Ramji
Publikováno v:
Journal of Porphyrins and Phthalocyanines. 22:371-397
The design of self oxidation-resistant catalytic materials based on organic molecules, although advantageous due to the ability to control their structures, is limited by the presence of labile C–H bonds. This mini review summarizes recent work aim
Autor:
Stephen J. Lippard, Mikael A. Minier, Fang Wang, Megan N. Jackson, Andrei Loas, Sabine Becker
Publikováno v:
Inorganic Chemistry. 56:11050-11058
We introduce a novel platform to mimic the coordination environment of carboxylate-bridged diiron proteins by tethering a small, dangling internal carboxylate, (CH2)nCOOH, to phenol-imine macrocyclic ligands (H3PIMICn). In the presence of an external
Autor:
Stephen J. Lippard, Andrei Loas
Publikováno v:
Journal of Materials Chemistry B. 5:8929-8933
We report the first Cu(ii)-based fluorescent sensors for ratiometric detection of nitric oxide. The two probes operate by energy transfer between hydroxycoumarin and fluorescein chromophores, contain polyproline or piperazine as rigid spacers, and el
Autor:
Andrei Loas, Sergiu M. Gorun
Publikováno v:
European Journal of Inorganic Chemistry. 2016:2648-2657
We report the synthesis, spectroscopy and X-ray structural characterization of seven new mixed alkyl-perfluoroalkyl silver tris(pyrazolyl)borate complexes with the general formula TpAg, where RF = CF3 or C2F5. The metal is partly encapsulated in a fl