Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Ajit Jadhav"'
Autor:
Hongchao Zheng, Andrew L. McIver, Surendra Karavadhi, Adam Yasgar, William J. Moore, Li Liu, Zhuyin Li, Carleen Klumpp-Thomas, Ajit Jadhav, Natalia J. Martinez, Kyle R. Brimacombe, Mindy I. Davis, Wei Zhao, Daniel J. Urban, Stephen V. Frye, Anton Simeonov, Xiaodong Wang, Samarjit Patnaik, Rajan Pragani, Mark J. Henderson, Weihe Zhang, Melinda G. Hollingshead, Min Shen, Qingyang Liu, Gordon M. Stott, Tobie D. Lee, Sam Michael, Matthew B. Boxer, Jason M. Rohde, Matthew D. Hall, Yuhong Fang, Joseph M. Covey, Dorian M. Cheff
Publikováno v:
J Med Chem
Neomorphic mutations in isocitrate dehydrogenase 1 (IDH1) are oncogenic for a number of malignancies, primarily low-grade gliomas and acute myeloid leukemia (AML). We report a medicinal chemistry campaign around a 7,7-dimethyl-7,8-dihydro-2H-1λ(2)-q
Autor:
Alexey V. Zakharov, Darrell L. Peterson, Adam Yasgar, Ajit Jadhav, Daniel C. Talley, Rong Huang, Anton Simeonov, Guangping Dong, Ken Chih-Chien Cheng
Publikováno v:
ACS Comb Sci
Methyltransferases (MTases) play diverse roles in cellular processes. Aberrant methylation levels have been implicated in many diseases, indicating the need for the identification and development of small molecule inhibitors for each MTase. Specific
Autor:
Tyler Peryea, Genaro S. Scavello, Zangdong He, Joseph Boyer, Pat Brady, Deepak Bandyopadhyay, Rajarshi Guha, Ajit Jadhav, Constantine Kreatsoulas, Dac-Trung Nguyen
Publikováno v:
Journal of Chemical Information and Modeling. 59:4880-4892
We present a method for visualizing and navigating large screening datasets while also taking into account their activities and properties. Our approach is to annotate the data with all possible scaffolds contained within each molecule. We have devel
Autor:
Matthew D. Hall, David J. Maloney, Amy Wang, Jeffrey W. Strovel, Makoto Yoshioka, Daniel J. Urban, Xin Xu, Shyh-Ming Yang, Pranav Shah, Ajit Jadhav, Steven Fletcher, Xin Hu
Publikováno v:
Bioorg Med Chem Lett
A new series of quinazoline-based analogs as potent bromodomain-containing protein 4 (BRD4) inhibitors is described. The structure-activity relationships on 2- and 4-position of quinazoline ring, and the substitution at 6-position that mimic the acet
Autor:
Douglas R. Davies, Gloria A. Benavides, Xin Hu, Jeffrey P. Norenberg, Somnath Jana, Ganesha Rai, Pavan Muttil, Larry A. Sklar, Katherine Pohida, Daniel J. Urban, Kabir, David M. Dranow, Andrew J. Flint, Leonard M. Neckers, Giuseppe L. Squadrito, David J. Maloney, William J. Moore, Victor M. Darley-Usmar, Elias C. Padilha, Ajit Jadhav, Matthew D. Hall, Kyle R. Brimacombe, Dorian M. Cheff, Anton Simeonov, Nitesh K. Kunda, Plamen P. Christov, Pranav Shah, Tamara Anderson, Dingyin Tao, Hu Zhu, Murali Cherukuri, Yuhong Fang, Shyh-Ming Yang, Gary A. Sulikowski, Gordon M. Stott, Donna F. Kusewitt, Tobie D. Lee, Chi V. Dang, Alex G. Waterson, Mark J. Henderson, Bryan T. Mott, Kwangho Kim, Michelle S. Johnson, Helen J. Hathaway, Nobu Oshima
Publikováno v:
J Med Chem
Lactate dehydrogenase (LDH) catalyzes the conversion of pyruvate to lactate, with concomitant oxidation of reduced nicotinamide adenine dinucleotide as the final step in the glycolytic pathway. Glycolysis plays an important role in the metabolic plas
Autor:
Jordan L. Meier, Abigail L. Thorpe, Carissa Grose, Ajit Jadhav, Jonathan H. Shrimp, Stephanie R. T. Widmeyer
Publikováno v:
ACS Chemical Biology. 13:455-460
Lysine acetyltransferases (KATs) play a critical role in the regulation of transcription and other genomic functions. However, a persistent challenge is the development of assays capable of defining KAT activity directly in living cells. Towards this
Autor:
Alexander Allweil, Somnath Jana, Ganesha Rai, Christine Lukacs, Bryan T. Mott, Xin Hu, Plamen P. Christov, Daniel J. Urban, David J. Maloney, Gary A. Sulikowski, Andrew J. Flint, William J. Moore, Ajit Jadhav, Alex G. Waterson, Kyle R. Brimacombe, Neal Jeffrey Green, Douglas R. Davies, Matthew D. Hall, Alexander P. Lamers, Gordon M. Stott, Tobie D. Lee, Ian M. Romaine, Kwangho Kim
Publikováno v:
Bioorg Med Chem Lett
Lactate dehydrogenase (LDH) is a critical enzyme in the glycolytic metabolism pathway that is used by many tumor cells. Inhibitors of LDH may be expected to inhibit the metabolic processes in cancer cells and thus selectively delay or inhibit growth
Publikováno v:
Environmental Earth Sciences. 78
The purpose of this study is to understand soil loss due to rain runoff and its relation to soil geoelectrical properties influencing vulnerability of soils. The relationship between soil geoelectric properties and rain runoff-based soil loss estimat
Autor:
David J. Maloney, Daniel J. Urban, Shyh-Ming Yang, Makoto Yoshioka, Xin Hu, Jeffrey Strovel, Ajit Jadhav, Matthew D. Hall
Publikováno v:
Bioorg Med Chem Lett
Extensive optimization of quinazoline-based lead 8 is described. The structure-activity relationship studies indicate the S-configuration is preferred for the phenylmorpholine substitution. Together with incorporation of a (2-hydroxyl-2-methylpropyl)
Autor:
Jingqui Dai, Alexey V. Melnik, Jenan J. Kharbush, Kenji L. Kurita, Robert A. Keyzers, Katrina M. Waters, Mario Sandoval-Calderón, Ajit Jadhav, Clifford A. Kapono, Charles B. Larson, Evgenia Glukhov, Danielle VanLeer, Daniel P. Demarque, Lars Jelsbak, Yi Zeng, Eve A. Granatosky, Kit Pogliano, Maryam Elfeki, Marcelino Gutiérrez, Jeramie D. Watrous, Katherine R. Duncan, Laura M. Sanchez, Jeremy Carver, Brendan M. Duggan, Thomas O. Metz, Julia A. Vorholt, Pep Charusanti, Paul Shinn, Nuno Bandeira, Pavel A. Pevzner, Amy C. Sims, Nobuhiro Koyama, David Gonzalez, Xueting Liu, Denise Brentan Silva, Venkat R. Macherla, Pieter C. Dorrestein, Andrew R. Johnson, Jörn Piel, Michael J. Meehan, Delphine Parrot, Jehad Almaliti, Don D. Nguyen, Louis-Félix Nothias, Wenyuan Shi, Max Crüsemann, Cristopher A. Boya P., Philip G. Williams, Erin E. Carlson, Ronnie G. Gavilan, Yao Peng, Roland D. Kersten, Jennifer E. Kyle, Bertrand Aigle, Yu-Liang Yang, Mingxun Wang, Amina Bouslimani, Lixin Zhang, Ram P. Neupane, Chih-Chuang Liaw, Tyler Peryea, Eric J. N. Helfrich, Kristian Fog Nielsen, Hans-Ulrich Humpf, Robert A. Quinn, Rolf Müller, Paul R. Jensen, Hailey Houson, Eduardo Esquenazi, Kathleen Dorrestein, Vanessa V. Phelan, Bernhard O. Palsson, Lisa Vuong, Cheng-Chih Hsu, Sophie Tomasi, Trent R. Northen, Laura A. Pace, Marc Litaudon, Samantha J. Mascuch, Chen Zhang, Maria Maansson, Ashley M. Sidebottom, Vinayak Agarwal, Ricardo Pianta Rodrigues da Silva, Ellis C. O’Neill, Tal Luzzatto-Knaan, Florian Ryffel, Oliver B. Vining, Andrés M. C. Rodríguez, Andreas Klitgaard, Enora Briand, Brian T. Murphy, Neha Garg, Norberto Peporine Lopes, Ralph S. Baric, William H. Gerwick, Pierre-Marie Allard, Daniel Torres-Mendoza, Jeffrey S. McLean, Stefan Jenkins, Lena Gerwick, Theodore Alexandrov, Roger G. Linington, Egle Pociute, Christian Sohlenkamp, Joshua R. Gurr, Matthew F. Traxler, Wei-Ting Liu, Rob Knight, Anne Lamsa, Anna Edlund, Bradley S. Moore, Prasad Phapale, Hosein Mohimani, Karin Kleigrewe, Charlotte Frydenlund Michelsen, Lucas Miranda Marques, Niclas Engene, Jean-Luc Wolfender, Thomas Hoffman, Rachel J. Dutton, Dac-Trung Nguyen, Paul D. Boudreau, Dimitrios J. Floros, Kerry L. McPhail, Carla Porto, Brian E. Sedio
Publikováno v:
Nature Biotechnology
Nature Biotechnology, 2016, 34 (8), pp.828-837. ⟨10.1038/nbt.3597⟩
Nature Biotechnology, Vol. 34, No 8 (2016) pp. 828-837
Nature Biotechnology, Nature Publishing Group, 2016, 34 (8), pp.828-837. ⟨10.1038/nbt.3597⟩
Nature Biotechnology (1087-0156) (Nature Publishing Group), 2016-08, Vol. 34, N. 8, P. 828-837
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Wang, M, Carver, J J, Pevzner, P, Mohiman, H, Bandeira, N, Phelan, V V, Sanchez, L M, Garg, N, Watrous, J, Luzzatto-Knaa, T, Frydenlund Michelsen, C, Jelsbak, L, Månsson, M, Klitgaard, A & Nielsen, K F 2016, ' Sharing and community curation of mass spectrometry data with Global Natural Products Social Molecular Networking ', Nature Biotechnology, vol. 34, no. 8, pp. 828-837 . https://doi.org/10.1038/nbt.3597
Nature Biotechnology, 2016, 34 (8), pp.828-837. ⟨10.1038/nbt.3597⟩
Nature Biotechnology, Vol. 34, No 8 (2016) pp. 828-837
Nature Biotechnology, Nature Publishing Group, 2016, 34 (8), pp.828-837. ⟨10.1038/nbt.3597⟩
Nature Biotechnology (1087-0156) (Nature Publishing Group), 2016-08, Vol. 34, N. 8, P. 828-837
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Wang, M, Carver, J J, Pevzner, P, Mohiman, H, Bandeira, N, Phelan, V V, Sanchez, L M, Garg, N, Watrous, J, Luzzatto-Knaa, T, Frydenlund Michelsen, C, Jelsbak, L, Månsson, M, Klitgaard, A & Nielsen, K F 2016, ' Sharing and community curation of mass spectrometry data with Global Natural Products Social Molecular Networking ', Nature Biotechnology, vol. 34, no. 8, pp. 828-837 . https://doi.org/10.1038/nbt.3597
International audience; The potential of the diverse chemistries present in natural products (NP) for biotechnology and medicine remains untapped because NP databases are not searchable with raw data and the NP community has no way to share data othe