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Autor:
Broughton, Laura J.
Duramycin is a relatively small (~2kDa) tetracyclic peptide that has a defined three-dimensional (3D) structure, this structure forms a stable binding pocket which specifically recognises the plasma membrane phospholipid phosphatidylethanolamine (PE)
Externí odkaz:
https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.717065
Autor:
Purvis, Nina Louise
Intravoxel Incoherent Motion Imaging (IVIM) is a non-invasive MR-imaging technique that enables the measurement of cellularity and vascularity using diffusion-weighted (DW)-imaging. IVIM has been applied to various cancer types including breast cance
Externí odkaz:
https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.717058
Autor:
Moody, Hannah Louise
Malignant pleural mesothelioma (MPM) is associated with an extremely poor prognosis and the majority of patients are initially or rapidly become unresponsive to platinum-based chemotherapy. MicroRNA-31 (miR-31) is encoded on a genomic fragile site, 9
Externí odkaz:
https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.717048
Autor:
Patel, Rikesh
Radiotherapy has been reported to induce apoptosis and prevent the proliferation of malignant cells. Complete clinical response to neo-adjuvant long course chemoradiotherapy has been identified in up to 30% of patients with locally advanced rectal ca
Externí odkaz:
http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.705740
Autor:
Zahoor, Tosief
It is widely accepted that infection with Human Papilloma Virus (HPV) confers better outcomes and survival rates in head and neck squamous cell carcinoma (HNSCC) patients (80% 5-year survival) compared with HPV-negative counterparts (50% 5-year survi
Externí odkaz:
http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.705737
Autor:
Cheah, Ramsah
Radiotherapy remains the standard treat74ment for head and neck squamous cell carcinoma (HNSCC), however, resistance remains a real clinical problem despite the improvements and development of new treatment strategies. Patient outcome could potential
Externí odkaz:
http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.695475
Autor:
Robinson, Spencer
Background - Lung cancer is the second most common cancer diagnosed in the UK after breast cancer. Around 41,000 people were diagnosed with lung cancer in the UK in 2008 (or 112 people every day). Patients with symptoms suggestive of lung cancer usua
Externí odkaz:
http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.695474
Autor:
Brocklesby, Kayleigh Louise
All tumours must become vascularised in order to survive and metastasise, and initiate angiogenesis through the dysregulated and uncontrolled release of pro-angiogenic factors. Such uncontrolled angiogenesis leads to highly disordered and abnormal va
Externí odkaz:
http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.691403
Autor:
Montgomery, Anne
Prostate cancer (PCa) is a unique and controversial disease. This is at least due to the high prevalence of latent disease, increasing amounts of which is being diagnosed, most of which is indolent and not lead to death, and for which treatment carri
Externí odkaz:
https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.667191
Optimisation of the Lister strain of vaccinia virus for use as an anticancer immunotherapeutic agent
Autor:
Ahmed, Jahangir
The premise of this project was to engineer a novel viral platform with the capacity to enhance antitumour immunity. To this effect, the N1L gene was disrupted in a Lister strain vaccinia viral backbone that had previously been engineered to be tumou
Externí odkaz:
https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.674900