Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Todd L. Edwards"'
Autor:
Elizabeth A. Jasper, Jacklyn N. Hellwege, Joseph H. Breeyear, Brenda Xiao, Gail P. Jarvik, Ian B. Stanaway, Kathleen A. Leppig, Geetha Chittoor, M. Geoffrey Hayes, Ozan Dikilitas, Iftikhar J. Kullo, Ingrid A. Holm, Shefali Setia Verma, Todd L. Edwards, Digna R. Velez Edwards
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-9 (2024)
Abstract Preeclampsia, a pregnancy complication characterized by hypertension after 20 gestational weeks, is a major cause of maternal and neonatal morbidity and mortality. Mechanisms leading to preeclampsia are unclear; however, there is evidence of
Externí odkaz:
https://doaj.org/article/593f321d88b040258ab9f27c654b2a15
Autor:
Markus Scholz, Katrin Horn, Janne Pott, Matthias Wuttke, Andreas Kühnapfel, M. Kamal Nasr, Holger Kirsten, Yong Li, Anselm Hoppmann, Mathias Gorski, Sahar Ghasemi, Man Li, Adrienne Tin, Jin-Fang Chai, Massimiliano Cocca, Judy Wang, Teresa Nutile, Masato Akiyama, Bjørn Olav Åsvold, Nisha Bansal, Mary L. Biggs, Thibaud Boutin, Hermann Brenner, Ben Brumpton, Ralph Burkhardt, Jianwen Cai, Archie Campbell, Harry Campbell, John Chalmers, Daniel I. Chasman, Miao Ling Chee, Miao Li Chee, Xu Chen, Ching-Yu Cheng, Renata Cifkova, Martha Daviglus, Graciela Delgado, Katalin Dittrich, Todd L. Edwards, Karlhans Endlich, J. Michael Gaziano, Ayush Giri, Franco Giulianini, Scott D. Gordon, Daniel F. Gudbjartsson, Stein Hallan, Pavel Hamet, Catharina A. Hartman, Caroline Hayward, Iris M. Heid, Jacklyn N. Hellwege, Bernd Holleczek, Hilma Holm, Nina Hutri-Kähönen, Kristian Hveem, Berend Isermann, Jost B. Jonas, Peter K. Joshi, Yoichiro Kamatani, Masahiro Kanai, Mika Kastarinen, Chiea Chuen Khor, Wieland Kiess, Marcus E. Kleber, Antje Körner, Peter Kovacs, Alena Krajcoviechova, Holly Kramer, Bernhard K. Krämer, Mikko Kuokkanen, Mika Kähönen, Leslie A. Lange, James P. Lash, Terho Lehtimäki, Hengtong Li, Bridget M. Lin, Jianjun Liu, Markus Loeffler, Leo-Pekka Lyytikäinen, Patrik K. E. Magnusson, Nicholas G. Martin, Koichi Matsuda, Yuri Milaneschi, Pashupati P. Mishra, Nina Mononen, Grant W. Montgomery, Dennis O. Mook-Kanamori, Josyf C. Mychaleckyj, Winfried März, Matthias Nauck, Kjell Nikus, Ilja M. Nolte, Raymond Noordam, Yukinori Okada, Isleifur Olafsson, Albertine J. Oldehinkel, Brenda W. J. H. Penninx, Markus Perola, Nicola Pirastu, Ozren Polasek, David J. Porteous, Tanja Poulain, Bruce M. Psaty, Ton J. Rabelink, Laura M. Raffield, Olli T. Raitakari, Humaira Rasheed, Dermot F. Reilly, Kenneth M. Rice, Anne Richmond, Paul M. Ridker, Jerome I. Rotter, Igor Rudan, Charumathi Sabanayagam, Veikko Salomaa, Neil Schneiderman, Ben Schöttker, Mario Sims, Harold Snieder, Klaus J. Stark, Kari Stefansson, Hannah Stocker, Michael Stumvoll, Patrick Sulem, Gardar Sveinbjornsson, Per O. Svensson, E-Shyong Tai, Kent D. Taylor, Bamidele O. Tayo, Andrej Teren, Yih-Chung Tham, Joachim Thiery, Chris H. L. Thio, Laurent F. Thomas, Johanne Tremblay, Anke Tönjes, Peter J. van der Most, Veronique Vitart, Uwe Völker, Ya Xing Wang, Chaolong Wang, Wen Bin Wei, John B. Whitfield, Sarah H. Wild, James F. Wilson, Thomas W. Winkler, Tien-Yin Wong, Mark Woodward, Xueling Sim, Audrey Y. Chu, Mary F. Feitosa, Unnur Thorsteinsdottir, Adriana M. Hung, Alexander Teumer, Nora Franceschini, Afshin Parsa, Anna Köttgen, Pascal Schlosser, Cristian Pattaro
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract X-chromosomal genetic variants are understudied but can yield valuable insights into sexually dimorphic human traits and diseases. We performed a sex-stratified cross-ancestry X-chromosome-wide association meta-analysis of seven kidney-relat
Externí odkaz:
https://doaj.org/article/268d127148904565be810f5bb7b9bb96
Autor:
Jeewoo Kim, Ariel Williams, Hannah Noh, Megan M. Shuey, Todd L. Edwards, Digna R. Velez Edwards, Jacklyn N. Hellwege
Publikováno v:
Journal of Clinical and Translational Science, Vol 8, Pp 128-129 (2024)
OBJECTIVES/GOALS: Uterine fibroids are benign tumors of the uterus with a high disease prevalence and burden, yet there are few multi-ancestry genetic studies. This is the largest and most diverse fibroid GWAS to-date. Our goal is to identify novel g
Externí odkaz:
https://doaj.org/article/d875c36e29194fe6a46c0f0328562f8b
Autor:
Nicole D. Armstrong, Vinodh Srinivasasainagendra, Farah Ammous, Themistocles L. Assimes, Amber L. Beitelshees, Jennifer Brody, Brian E. Cade, Yii-Der Ida Chen, Han Chen, Paul S. de Vries, James S. Floyd, Nora Franceschini, Xiuqing Guo, Jacklyn N. Hellwege, John S. House, Chii-Min Hwu, Sharon L. R. Kardia, Ethan M. Lange, Leslie A. Lange, Caitrin W. McDonough, May E. Montasser, Jeffrey R. O’Connell, Megan M. Shuey, Xiao Sun, Rikki M. Tanner, Zhe Wang, Wei Zhao, April P. Carson, Todd L. Edwards, Tanika N. Kelly, Eimear E. Kenny, Charles Kooperberg, Ruth J. F. Loos, Alanna C. Morrison, Alison Motsinger-Reif, Bruce M. Psaty, Dabeeru C. Rao, Susan Redline, Stephen S. Rich, Jerome I. Rotter, Jennifer A. Smith, Albert V. Smith, Marguerite R. Irvin, Donna K. Arnett
Publikováno v:
Frontiers in Genetics, Vol 14 (2023)
Introduction: Apparent treatment-resistant hypertension (aTRH) is characterized by the use of four or more antihypertensive (AHT) classes to achieve blood pressure (BP) control. In the current study, we conducted single-variant and gene-based analyse
Externí odkaz:
https://doaj.org/article/7b206fd782484f169fb7415ed4c3d533
Autor:
Catherine Anne Greene, Gabrielle Hampton, Gail P. Jarvik, Bahram Namjou-Khales, Atlas Khan, Yuan Luo, Todd L. Edwards, Digna R. Velez Edwards, Jacklyn N. Hellwege
Publikováno v:
Journal of Clinical and Translational Science, Vol 8, Pp 13-13 (2024)
OBJECTIVES/GOALS: We aimed to conduct an updated genome-wide meta-analysis of keloids in expanded populations, including those most afflicted by keloids. Our overall objective was to improve understanding of keloid development though the identificati
Externí odkaz:
https://doaj.org/article/9ecc5cf5b0fa4a678f8946cb245c092f
Autor:
Elizabeth A. Jasper, Jacklyn N. Hellwege, Jacqueline A. Piekos, Sarah H. Jones, Katherine E. Hartmann, Brian Mautz, David M. Aronoff, Todd L. Edwards, Digna R. Velez Edwards
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract The placenta is critical to human growth and development and has been implicated in health outcomes. Understanding the mechanisms through which the placenta influences perinatal and later-life outcomes requires further investigation. We eval
Externí odkaz:
https://doaj.org/article/811a5d94ec764a988035dd8d2f7a3f0c
Autor:
Jacob Joseph, Chang Liu, Qin Hui, Krishna Aragam, Zeyuan Wang, Brian Charest, Jennifer E. Huffman, Jacob M. Keaton, Todd L. Edwards, Serkalem Demissie, Luc Djousse, Juan P. Casas, J. Michael Gaziano, Kelly Cho, Peter W. F. Wilson, Lawrence S. Phillips, VA Million Veteran Program, Christopher J. O’Donnell, Yan V. Sun
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
While the genetic basis of heart failure has been explored by genetic studies, the differences between subtypes are not well understood. Here, the authors performed genetic analyses on the two major subtypes of heart failure in a large biobank with g
Externí odkaz:
https://doaj.org/article/e336b622512a4d6490ab2f196676b283
Autor:
Megan M. Shuey, Kyung Min Lee, Jacob Keaton, Nikhil K. Khankari, Joseph H. Breeyear, Venexia M. Walker, Donald R. Miller, Kent R. Heberer, Peter D. Reaven, Shoa L. Clarke, Jennifer Lee, Julie A. Lynch, Marijana Vujkovic, Todd L. Edwards
Publikováno v:
EBioMedicine, Vol 94, Iss , Pp 104674- (2023)
Summary: Background: The identification of new uses for existing drug therapies has the potential to identify treatments for comorbid conditions that have the added benefit of glycemic control while also providing a rapid, low-cost approach to drug (
Externí odkaz:
https://doaj.org/article/0a32e0fd304d4bea90a5c225732f57ca
Autor:
Patrick Wu, QiPing Feng, Vern Eric Kerchberger, Scott D. Nelson, Qingxia Chen, Bingshan Li, Todd L. Edwards, Nancy J. Cox, Elizabeth J. Phillips, C. Michael Stein, Dan M. Roden, Joshua C. Denny, Wei-Qi Wei
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Prioritizing drug repurposing candidates for downstream studies remains challenging. Here, the authors present a high-throughput approach to identify and validate drug repurposing candidates, integrating human gene expression, drug perturbation, and
Externí odkaz:
https://doaj.org/article/21ab9d056390420ba81493fa1607bba7
Autor:
Nikhil K. Khankari, Jacob M. Keaton, Venexia M. Walker, Kyung Min Lee, Megan M. Shuey, Shoa L. Clarke, Kent R. Heberer, Donald R. Miller, Peter D. Reaven, Julie A. Lynch, Marijana Vujkovic, Todd L. Edwards
Publikováno v:
EBioMedicine, Vol 80, Iss , Pp 104038- (2022)
Summary: Background: Maintaining a healthy lifestyle to reduce type 2 diabetes (T2D) risk is challenging and additional strategies for T2D prevention are needed. We evaluated several lipid control medications as potential therapeutic options for T2D
Externí odkaz:
https://doaj.org/article/40b062220d4c4983bd63137c4ba814a9