Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Simon Lord"'
Autor:
Pavlina Spiliopoulou, Farasat Kazmi, Francesca Aroldi, Thomas Holmes, David Thompson, Lucinda Griffiths, Cathy Qi, Matthew Parkes, Simon Lord, Gareth J. Veal, David J. Harrison, Vicky M. Coyle, Jill Graham, Thomas R. Jeffry Evans, Sarah P. Blagden
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 43, Iss 1, Pp 1-16 (2024)
Abstract Purpose 5-fluorouracil (5-FU) is inefficiently converted to the active anti-cancer metabolite, fluorodeoxyuridine-monophosphate (FUDR-MP), is associated with dose-limiting toxicities and challenging administration schedules. NUC-3373 is a ph
Externí odkaz:
https://doaj.org/article/8de199adb6da4ff4b44e74190f835493
Autor:
Miriam Dixon-Zegeye, Rachel Shaw, Linda Collins, Kendra Perez-Smith, Alexander Ooms, Maggie Qiao, Pan Pantziarka, Louise Izatt, Marc Tischkowitz, Rachel E. Harrison, Angela George, Emma R. Woodward, Simon Lord, Lara Hawkes, D. Gareth Evans, James Franklin, Helen Hanson, Sarah P. Blagden
Publikováno v:
Trials, Vol 25, Iss 1, Pp 1-14 (2024)
Abstract Background Li-Fraumeni syndrome (LFS) is a rare autosomal dominant disease caused by inherited or de novo germline pathogenic variants in TP53. Individuals with LFS have a 70–100% lifetime risk of developing cancer. The current standard of
Externí odkaz:
https://doaj.org/article/cf49679192c94035afcc32e77d21fae6
Autor:
Matthew Stuible, Joseph D. Schrag, Joey Sheff, Daria Zoubchenok, Simon Lord-Dufour, Brian Cass, Denis L’Abbé, Alex Pelletier, Martin A. Rossotti, Jamshid Tanha, Christian Gervais, Roger Maurice, Majida El Bakkouri, Mauro Acchione, Yves Durocher
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract SARS-CoV-2 subunit vaccines continue to be the focus of intense clinical development worldwide. Protein antigens in these vaccines most commonly consist of the spike ectodomain fused to a heterologous trimerization sequence, designed to mimi
Externí odkaz:
https://doaj.org/article/dc399963cdec43a6ac763c16fa63044f
Autor:
Ash Kieran Clift, MBBS, Gary S Collins, ProfPhD, Simon Lord, DPhil, Stavros Petrou, ProfPhD, David Dodwell, MD, Michael Brady, ProfPhD, Julia Hippisley-Cox, ProfMD
Publikováno v:
The Lancet: Digital Health, Vol 5, Iss 9, Pp e571-e581 (2023)
Summary: Background: Identifying female individuals at highest risk of developing life-threatening breast cancers could inform novel stratified early detection and prevention strategies to reduce breast cancer mortality, rather than only considering
Externí odkaz:
https://doaj.org/article/278020f1ad52472cbfafa7c0bb68b4d4
Publikováno v:
Exploration of Targeted Anti-tumor Therapy, Vol 3, Iss 2, Pp 172-199 (2022)
The majority of breast cancers express the estrogen receptor (ER) and for this group of patients, endocrine therapy is the cornerstone of systemic treatment. However, drug resistance is common and a focus for breast cancer preclinical and clinical re
Externí odkaz:
https://doaj.org/article/652669df8df04cf0a2f4e0478567df96
Autor:
Shaveta Mehta, Nick P. Hughes, Sonia Li, Adrian Jubb, Rosie Adams, Simon Lord, Lefteris Koumakis, Ruud van Stiphout, Anwar Padhani, Andreas Makris, Francesca M. Buffa, Adrian L. Harris
Publikováno v:
EBioMedicine, Vol 10, Iss C, Pp 109-116 (2016)
Anti-VEGF antibody bevacizumab has prolonged progression-free survival in several cancer types, however acquired resistance is common. Adaption has been observed pre-clinically, but no human study has shown timing and genes involved, enabling formula
Externí odkaz:
https://doaj.org/article/95b51e0dd07d4b28af30ade436d7ddd8
Autor:
Karim Bensaad, Elena Favaro, Caroline A. Lewis, Barrie Peck, Simon Lord, Jennifer M. Collins, Katherine E. Pinnick, Simon Wigfield, Francesca M. Buffa, Ji-Liang Li, Qifeng Zhang, Michael J.O. Wakelam, Fredrik Karpe, Almut Schulze, Adrian L. Harris
Publikováno v:
Cell Reports, Vol 9, Iss 1, Pp 349-365 (2014)
Summary: An in vivo model of antiangiogenic therapy allowed us to identify genes upregulated by bevacizumab treatment, including Fatty Acid Binding Protein 3 (FABP3) and FABP7, both of which are involved in fatty acid uptake. In vitro, both were indu
Externí odkaz:
https://doaj.org/article/e1e264078b5c49b6b6c2525e5f12d70f
Publikováno v:
Drug Target Insights, Vol 2012, Iss 6, Pp 1-11 (2012)
Externí odkaz:
https://doaj.org/article/c0654b83223f4360a99b744feee277d8
Publikováno v:
Drug Target Insights, Vol 6, Iss 1 (2012)
Abstract non disponibile
Externí odkaz:
https://doaj.org/article/16d9f057753a4d67b03a702c4015d7a6
Publikováno v:
Journal of Comparative Legislation and International Law, 1945 Jan 01. 27(1/2), xix-xxvii.
Externí odkaz:
https://www.jstor.org/stable/754845