Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Scott A. Summers"'
Autor:
Marie K. Norris, Trevor S. Tippetts, Joseph L. Wilkerson, Rebekah J. Nicholson, J. Alan Maschek, Thierry Levade, Jeffrey A. Medin, Scott A. Summers, William L. Holland
Publikováno v:
Molecular Genetics and Metabolism Reports, Vol 39, Iss , Pp 101077- (2024)
Farber Disease is a debilitating and lethal childhood disease of ceramide accumulation caused by acid ceramidase deficiency. The potent induction of a ligand-gated neutral ceramidase activity promoted by adiponectin may provide sufficient lowering of
Externí odkaz:
https://doaj.org/article/fd1f0a9001544ffca316b6e632fe7b03
Autor:
Rhea Harewood, Joseph A. Rothwell, Jelena Bešević, Vivian Viallon, David Achaintre, Audrey Gicquiau, Sabina Rinaldi, Roland Wedekind, Cornelia Prehn, Jerzy Adamski, Julie A. Schmidt, Inarie Jacobs, Anne Tjønneland, Anja Olsen, Gianluca Severi, Rudolf Kaaks, Verena Katzke, Matthias B. Schulze, Marcela Prada, Giovanna Masala, Claudia Agnoli, Salvatore Panico, Carlotta Sacerdote, Paula Gabriela Jakszyn, Maria-Jose Sánchez, Jesús Castilla, María-Dolores Chirlaque, Amaia Aizpurua Atxega, Bethany van Guelpen, Alicia K. Heath, Keren Papier, Tammy Y.N. Tong, Scott A. Summers, Mary Playdon, Amanda J. Cross, Pekka Keski-Rahkonen, Véronique Chajès, Neil Murphy, Marc J. Gunter
Publikováno v:
EBioMedicine, Vol 101, Iss , Pp 105024- (2024)
Summary: Background: Altered lipid metabolism is a hallmark of cancer development. However, the role of specific lipid metabolites in colorectal cancer development is uncertain. Methods: In a case–control study nested within the European Prospectiv
Externí odkaz:
https://doaj.org/article/db0b1c75776340c68fff5c55e1fdf881
Autor:
Mohamed Ibrahim Madkour, Md Torikul Islam, Trevor S. Tippetts, Kamrul H. Chowdhury, Lisa A. Lesniewski, Scott A. Summers, Falak Zeb, Dana N. Abdelrahim, Refat AlKurd, Husam M. Khraiwesh, Katia H. AbuShihab, Asma AlBakri, Khaled Obaideen, MoezAlIslam E. Faris
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract Intermittent fasting (IF) is associated with enormous metabolic alterations that underpin its diverse health effects. Changes in lipid metabolism, particularly ceramides, and other sphingolipids, are among the most notable of these alteratio
Externí odkaz:
https://doaj.org/article/49eafbe69905430b812bf00741473808
Autor:
Tara R. Price, Christopher H. Emfinger, Kathryn L. Schueler, Sarah King, Rebekah Nicholson, Tim Beck, Brian S. Yandell, Scott A. Summers, William L. Holland, Ronald M. Krauss, Mark P. Keller, Alan D. Attie
Publikováno v:
Journal of Lipid Research, Vol 64, Iss 12, Pp 100471- (2023)
Despite great progress in understanding lipoprotein physiology, there is still much to be learned about the genetic drivers of lipoprotein abundance, composition, and function. We used ion mobility spectrometry to survey 16 plasma lipoprotein subfrac
Externí odkaz:
https://doaj.org/article/6ad83e9149c14cb19d8e30950906c97d
Autor:
Mohamed Ibrahim Madkour, Md Torikul Islam, Trevor S. Tippetts, Kamrul H. Chowdhury, Lisa A. Lesniewski, Scott A. Summers, Falak Zeb, Dana N. Abdelrahim, Refat AlKurd, Husam M. Khraiwesh, Katia H. AbuShihab, Asma AlBakri, Khaled Obaideen, MoezAlIslam E. Faris
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-2 (2023)
Externí odkaz:
https://doaj.org/article/4855c837d467433e8110a86da677e726
Autor:
Maci Winn, Prasoona Karra, Benjamin Haaland, Jennifer A. Doherty, Scott A. Summers, Michelle L. Litchman, Marc J. Gunter, Mary C. Playdon, Sheetal Hardikar
Publikováno v:
Cancer Medicine, Vol 12, Iss 1, Pp 606-618 (2023)
Abstract Background Metabolic syndrome (MetS), a group of risk factors that define metabolic dysfunction in adults, is strongly associated with obesity and is an emerging risk factor for cancer. However, the association of MetS and degree of metaboli
Externí odkaz:
https://doaj.org/article/b46a2bbe90c549d88a1c18a306295d51
Autor:
Christopher A. Simeone, Joseph L. Wilkerson, Annelise M. Poss, James A. Banks, Joseph V. Varre, Jose Lazaro Guevara, Edgar Javier Hernandez, Bushra Gorsi, Donald L. Atkinson, Tursun Turapov, Scott G. Frodsham, Julio C. Fierro Morales, Kristina O’Neil, Barry Moore, Mark Yandell, Scott A. Summers, Andrzej S. Krolewski, William L. Holland, Marcus G. Pezzolesi
Publikováno v:
npj Genomic Medicine, Vol 7, Iss 1, Pp 1-8 (2022)
Abstract Adiponectin, encoded by ADIPOQ, is an insulin-sensitizing, anti-inflammatory, and renoprotective adipokine that activates receptors with intrinsic ceramidase activity. We identified a family harboring a 10-nucleotide deletion mutation in ADI
Externí odkaz:
https://doaj.org/article/250d25ef59fc4c589b2a1e3ae70ec7b4
Autor:
Ying Li, Chad Lamar Talbot, Bhawna Chandravanshi, Alec Ksiazek, Ayushi Sood, Kamrul Hasan Chowdhury, J. Alan Maschek, James Cox, Adhini Kuppuswamy Satheesh Babu, Henry A. Paz, Pon Velayutham Anandh Babu, David K. Meyerholz, Umesh D. Wankhade, William Holland, E. Shyong Tai, Scott A. Summers, Bhagirath Chaurasia
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)
Abstract Ectopic ceramide accumulation in insulin-responsive tissues contributes to the development of obesity and impairs insulin sensitivity. Moreover, pharmacological inhibition of serine palmitoyl transferase (SPT), the first enzyme essential for
Externí odkaz:
https://doaj.org/article/fa076134ba1d4bf2a890c2226b76f5d5
Autor:
Scott A. Summers
Publikováno v:
Journal of Lipid and Atherosclerosis, Vol 9, Iss 1, Pp 50-65 (2020)
Ceramides are minor components of the hepatic lipidome that have major effects on liver function. These products of lipid and protein metabolism accumulate when the energy needs of the hepatocyte have been met and its storage capacity is full, such t
Externí odkaz:
https://doaj.org/article/66c791b08c904bdc82a08a43738eefaa
Autor:
Bhagirath Chaurasia, Li Ying, Chad Lamar Talbot, John Alan Maschek, James Cox, Edward H. Schuchman, Yoshio Hirabayashi, William L. Holland, Scott A. Summers
Publikováno v:
Molecular Metabolism, Vol 45, Iss , Pp 101145- (2021)
Objective: Aging and weight gain lead to a decline in brown and beige adipocyte functionality that exacerbates obesity and insulin resistance. We sought to determine whether sphingolipids, such as ceramides, a class of lipid metabolites that accumula
Externí odkaz:
https://doaj.org/article/9975020d704c4ea98cfc8e762cab31b4