Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Raúl R. Rodrigues-Díez"'
Autor:
Lucas Opazo-Ríos, Antonio Tejera-Muñoz, Manuel Soto Catalan, Vanessa Marchant, Carolina Lavoz, Sebastián Mas Fontao, Juan Antonio Moreno, Marta Fierro Fernandez, Ricardo Ramos, Beatriz Suarez-Alvarez, Carlos López-Larrea, Marta Ruiz-Ortega, Jesús Egido, Raúl R. Rodrigues-Díez
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Diabetic nephropathy (DN) is the main leading cause of chronic kidney disease worldwide. Although remarkable therapeutic advances have been made during the last few years, there still exists a high residual risk of disease progression to end-stage re
Externí odkaz:
https://doaj.org/article/1da83a47d26d4589802051a891591700
Autor:
Antonio Tejera-Muñoz, Isabel Rodríguez, Álvaro Del Río-García, Yamina Mohamedi, María Martín, Valentina Chiminazzo, Beatriz Suárez-Álvarez, Carlos López-Larrea, Marta Ruiz-Ortega, Raúl R. Rodrigues-Díez
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 23, p 15406 (2022)
Cellular communication network factor 2 (CCN2/CTGF) has been traditionally described as a downstream mediator of other profibrotic factors including transforming growth factor (TGF)-β and angiotensin II. However, recent evidence from our group demon
Externí odkaz:
https://doaj.org/article/833b0955923c4225b6363fdf45f31c14
Autor:
Sandra Rayego-Mateos, José Luis Morgado-Pascual, Carolina Lavoz, Raúl R. Rodrigues-Díez, Laura Márquez-Expósito, Antonio Tejera-Muñoz, Lucía Tejedor-Santamaría, Irene Rubio-Soto, Vanessa Marchant, Marta Ruiz-Ortega
Publikováno v:
Biomolecules, Vol 12, Iss 2, p 252 (2022)
Cellular communication network-2 (CCN2), also called connective tissue growth factor (CTGF), is considered a fibrotic biomarker and has been suggested as a potential therapeutic target for kidney pathologies. CCN2 is a matricellular protein with four
Externí odkaz:
https://doaj.org/article/46dc005de3084515b557898068a9a144
Autor:
Antonio Tejera-Muñoz, Laura Marquez-Exposito, Lucía Tejedor-Santamaría, Sandra Rayego-Mateos, Macarena Orejudo, Beatriz Suarez-Álvarez, Carlos López-Larrea, Marta Ruíz-Ortega, Raúl R. Rodrigues-Díez
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 1, p 375 (2021)
The cellular communication network factor 2 (CCN2/CTGF) has been traditionally described as a mediator of the fibrotic responses induced by other factors including the transforming growth factor β (TGF-β). However, several studies have defined a di
Externí odkaz:
https://doaj.org/article/d434cae997ff4cd68046f4997934677e
Autor:
Maria Laura Saiz, Laura Lozano-Chamizo, Aida Bernardo Florez, Marzia Marciello, Paula Diaz-Bulnes, Viviana Corte-Iglesias, Cristian Ruiz Bernet, Raul R. Rodrigues-Diez, Cristina Martin-Martin, Mar Rodriguez-Santamaria, Ivan Fernandez-Vega, Ramon M. Rodriguez, Carmen Diaz-Corte, Beatriz Suarez-Alvarez, Marco Filice, Carlos Lopez-Larrea
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 174, Iss , Pp 116492- (2024)
Targeting epigenetic mechanisms has emerged as a potential therapeutic approach for the treatment of kidney diseases. Specifically, inhibiting the bromodomain and extra-terminal (BET) domain proteins using the small molecule inhibitor JQ1 has shown p
Externí odkaz:
https://doaj.org/article/faef2a249ec44921b88449981de7a8ea
Autor:
Raúl R. Rodrigues-Diez, Antonio Tejera-Muñoz, Macarena Orejudo, Laura Marquez-Exposito, Laura Santos, Sandra Rayego-Mateos, Elena Cantero-Navarro, Lucia Tejedor-Santamaria, Vanessa Marchant, Alberto Ortiz, Jesús Egido, Sergio Mezzano, Rafael Selgas, Juan F. Navarro-González, Jose M. Valdivielso, Carolina Lavoz, Marta Ruiz-Ortega
Publikováno v:
Nefrología, Vol 41, Iss 3, Pp 244-257 (2021)
Resumen: La interleuquina 17A (IL-17A) es una citoquina proinflamatoria producida por células del sistema inmune, sobre todo por los linfocitos Th17 y los linfocitos γδ. En este trabajo, revisamos el papel de IL-17A en la patogenia de la hipertens
Externí odkaz:
https://doaj.org/article/bc4b6400203c47e4a3f975601cac4a51
Autor:
Raúl R. Rodrigues-Diez, Antonio Tejera-Muñoz, Macarena Orejudo, Laura Marquez-Exposito, Laura Santos-Sanchez, Sandra Rayego-Mateos, Elena Cantero-Navarro, Lucia Tejedor-Santamaria, Vanessa Marchant, Alberto Ortiz, Jesús Egido, Sergio Mezzano, Rafael Selgas, Juan F. Navarro-González, Jose M. Valdivielso, Carolina Lavoz, Marta Ruiz-Ortega
Publikováno v:
Nefrología (English Edition), Vol 41, Iss 3, Pp 244-257 (2021)
Interleukin-17A (IL-17A) is a proinflammatory cytokine produced by cells of the immune system, predominantly Th17 and γδ lymphocytes. In this paper, we review the role of IL-17A in the pathogenesis of hypertension and in target organ damage. Precli
Externí odkaz:
https://doaj.org/article/83149afb48cd47049f3cfeb094a5b112
Autor:
Milica Bozic, Maite Caus, Raul R. Rodrigues-Diez, Neus Pedraza, Marta Ruiz-Ortega, Eloi Garí, Pilar Gallel, Maria José Panadés, Ana Martinez, Elvira Fernández, José Manuel Valdivielso
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Renal fibrosis is a deleterious process and a final manifestation of chronic kidney disease. Here, the authors demonstrate a role of alpha-synuclein in the maintenance of the epithelial phenotype of renal proximal tubular epithelial cells and in prot
Externí odkaz:
https://doaj.org/article/1abf8b1a32e645768f299becb7117c14
Autor:
Elena Cantero-Navarro, Sandra Rayego-Mateos, Macarena Orejudo, Lucía Tejedor-Santamaria, Antonio Tejera-Muñoz, Ana Belén Sanz, Laura Marquez-Exposito, Vanessa Marchant, Laura Santos-Sanchez, Jesús Egido, Alberto Ortiz, Teresa Bellon, Raúl R. Rodrigues-Diez, Marta Ruiz-Ortega
Publikováno v:
Frontiers in Medicine, Vol 8 (2021)
Inflammation is a key characteristic of kidney disease, but this immune response is two-faced. In the acute phase of kidney injury, there is an activation of the immune cells to fight against the insult, contributing to kidney repair and regeneration
Externí odkaz:
https://doaj.org/article/eec648e0a92a47858d82fa4128d29513
Autor:
Laura Marquez-Exposito, Lucia Tejedor-Santamaria, Laura Santos-Sanchez, Floris A. Valentijn, Elena Cantero-Navarro, Sandra Rayego-Mateos, Raul R. Rodrigues-Diez, Antonio Tejera-Muñoz, Vanessa Marchant, Ana B. Sanz, Alberto Ortiz, Roel Goldschmeding, Marta Ruiz-Ortega
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Acute kidney injury (AKI) is more frequent in elderly patients. Mechanisms contributing to AKI (tubular cell death, inflammatory cell infiltration, impaired mitochondrial function, and prolonged cell-cycle arrest) have been linked to cellular senesce
Externí odkaz:
https://doaj.org/article/eb14e45a559945cd9ceb2ba0fcda3ed8