Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Michael Oberst"'
Autor:
Patrick Freeman, Gaia Bellomo, Lucy Ireland, Maidinaimu Abudula, Teifion Luckett, Michael Oberst, Ruth Stafferton, Paula Ghaneh, Chris Halloran, Michael C. Schmid, Ainhoa Mielgo
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal malignancy with an urgent unmet clinical need for new therapies. Using a combination of in vitro assays and in vivo preclinical models we demonstrate that therapeutic inhibition of the IGF si
Externí odkaz:
https://doaj.org/article/f2d2357408ad44d2ac20a8b008744c12
Autor:
Aung Naing, Jeffrey Infante, Sanjay Goel, Howard Burris, Chelsea Black, Shannon Marshall, Ikbel Achour, Susannah Barbee, Rena May, Chris Morehouse, Kristen Pollizzi, Xuyang Song, Keith Steele, Nairouz Elgeioushi, Farzana Walcott, Joyson Karakunnel, Patricia LoRusso, Amy Weise, Joseph Eder, Brendan Curti, Michael Oberst
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 7, Iss 1, Pp 1-15 (2019)
Abstract Background The safety, efficacy, pharmacokinetics, and pharmacodynamics of the anti-programmed cell death-1 antibody MEDI0680 were evaluated in a phase I, multicenter, dose-escalation study in advanced solid malignancies. Methods MEDI0680 wa
Externí odkaz:
https://doaj.org/article/cf9d82e0ebcd4aaeac76ef9a975cf4f7
Autor:
Darren J. Schofield, Jennifer Percival-Alwyn, Mateusz Rytelewski, John Hood, Raymond Rothstein, Leslie Wetzel, Kelly McGlinchey, Grace Adjei, Amanda Watkins, LeeAnn Machiesky, Weimin Chen, John Andrews, Maria Groves, Michelle Morrow, Ross A. Stewart, Andrew Leinster, Robert W. Wilkinson, Scott A. Hammond, Nadia Luheshi, Claire Dobson, Michael Oberst
Publikováno v:
mAbs, Vol 13, Iss 1 (2021)
Preclinical studies of PD-L1 and CTLA-4 blockade have relied heavily on mouse syngeneic tumor models with intact immune systems, which facilitate dissection of immunosuppressive mechanisms in the tumor microenvironment. Commercially developed monoclo
Externí odkaz:
https://doaj.org/article/5b7084f79f5a4c06ad3eff39bdaa115c
Autor:
Natalie J. Tigue, Lisa Bamber, John Andrews, Samantha Ireland, James Hair, Edward Carter, Sudharsan Sridharan, Jelena Jovanović, D. Gareth Rees, Jeremy S. Springall, Emilie Solier, Yi-Ming Li, Matthieu Chodorge, David Perez-Martinez, Daniel R. Higazi, Michael Oberst, Maureen Kennedy, Chelsea M. Black, Li Yan, Martin Schwickart, Shaun Maguire, Jennifer A. Cann, Lolke de Haan, Lesley L. Young, Tristan Vaughan, Robert W. Wilkinson, Ross Stewart
Publikováno v:
OncoImmunology, Vol 6, Iss 3 (2017)
Glucocorticoid-induced tumor necrosis factor receptor-related protein (GITR) is part of a system of signals involved in controlling T-cell activation. Targeting and agonizing GITR in mice promotes antitumor immunity by enhancing the function of effec
Externí odkaz:
https://doaj.org/article/2ce1d1f11ec645bc9ff9055a90e162ac
Autor:
Tingxiu Xiang, Lili Li, Xuedong Yin, Chenfu Yuan, Cui Tan, Xianwei Su, Lei Xiong, Thomas C Putti, Michael Oberst, Kathleen Kelly, Guosheng Ren, Qian Tao
Publikováno v:
PLoS ONE, Vol 7, Iss 1, p e29783 (2012)
BACKGROUND:Breast cancer (BrCa) is a complex disease driven by aberrant gene alterations and environmental factors. Recent studies reveal that abnormal epigenetic gene regulation also plays an important role in its pathogenesis. Ubiquitin carboxyl- t
Externí odkaz:
https://doaj.org/article/379a176ac3a24144aa67e0e2ee84d155
Autor:
Ke Li, Lei Gao, Zhaoxia Guo, Yucheng Dong, Enayat A. Moallemi, Gang Kou, Meiqian Chen, Wenhao Lin, Qi Liu, Michael Obersteiner, Matteo Pedercini, Brett A. Bryan
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-10 (2024)
Abstract China’s long-term sustainability faces socioeconomic and environmental uncertainties. We identify five key systemic risk drivers, called disruptors, which could push China into a polycrisis: pandemic disease, ageing and shrinking populatio
Externí odkaz:
https://doaj.org/article/ffaa9f409f4a4739a159395f3fe76ebf
Autor:
Martin Jung, Timothy M. Boucher, Stephen A. Wood, Christian Folberth, Michael Wironen, Philip Thornton, Deborah Bossio, Michael Obersteiner
Publikováno v:
PLoS ONE, Vol 19, Iss 2 (2024)
Externí odkaz:
https://doaj.org/article/70c9041d4db24bb58399fea2c45fed6d
Autor:
Christian Folberth, Stephen A Wood, Michael Wironen, Martin Jung, Timothy M Boucher, Deborah Bossio, Michael Obersteiner
Publikováno v:
Environmental Research Letters, Vol 19, Iss 4, p 044027 (2024)
Mineral nitrogen (N) fertilizer use is essential to maintain high-yielding cropping systems that presently provide food for nearly half of humanity. Simultaneously, it causes a range of detrimental impacts such as greenhouse gas emissions, eutrophica
Externí odkaz:
https://doaj.org/article/d0949a7d7b6b4f75a65757e60e807e7b
Autor:
Myroslava Lesiv, Dmitry Schepaschenko, Marcel Buchhorn, Linda See, Martina Dürauer, Ivelina Georgieva, Martin Jung, Florian Hofhansl, Katharina Schulze, Andrii Bilous, Volodymyr Blyshchyk, Liudmila Mukhortova, Carlos Luis Muñoz Brenes, Leonid Krivobokov, Stephan Ntie, Khongor Tsogt, Stephan Alexander Pietsch, Elena Tikhonova, Moonil Kim, Fulvio Di Fulvio, Yuan-Fong Su, Roma Zadorozhniuk, Flavius Sorin Sirbu, Kripal Panging, Svitlana Bilous, Sergii B. Kovalevskii, Florian Kraxner, Ahmed Harb Rabia, Roman Vasylyshyn, Rekib Ahmed, Petro Diachuk, Serhii S. Kovalevskyi, Khangsembou Bungnamei, Kusumbor Bordoloi, Andrii Churilov, Olesia Vasylyshyn, Dhrubajyoti Sahariah, Anatolii P. Tertyshnyi, Anup Saikia, Žiga Malek, Kuleswar Singha, Roman Feshchenko, Reinhard Prestele, Ibrar ul Hassan Akhtar, Kiran Sharma, Galyna Domashovets, Seth A. Spawn-Lee, Oleksii Blyshchyk, Oleksandr Slyva, Mariia Ilkiv, Oleksandr Melnyk, Vitalii Sliusarchuk, Anatolii Karpuk, Andrii Terentiev, Valentin Bilous, Kateryna Blyshchyk, Maxim Bilous, Nataliia Bogovyk, Ivan Blyshchyk, Sergey Bartalev, Mikhail Yatskov, Bruno Smets, Piero Visconti, Ian Mccallum, Michael Obersteiner, Steffen Fritz
Publikováno v:
Scientific Data, Vol 9, Iss 1, Pp 1-14 (2022)
Measurement(s) forest management type Technology Type(s) Geo-Wiki toolbox
Externí odkaz:
https://doaj.org/article/f6fd5cfdd81b4030a93498cc76b5b243
Publikováno v:
Frontiers in Environmental Science, Vol 10 (2022)
The social cost of carbon (SCC) is estimated by integrated assessment models (IAMs) and is widely used by government agencies to value climate policy impacts. Although there is an ongoing debate about obtained numerical estimates and related uncertai
Externí odkaz:
https://doaj.org/article/8627b3530e804118890c55e8a5f09ba8