Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Michael A. Portelli"'
Autor:
Michael A. Portelli, Sangita Bhaker, Vincent Pang, David O. Bates, Simon R. Johnson, Andrew P. Mazar, Dominick Shaw, Christopher Brightling, Ian Sayers
Publikováno v:
Clinical and Translational Allergy, Vol 13, Iss 10, Pp n/a-n/a (2023)
Abstract Background Expression of the urokinase plasminogen activator receptor (uPAR) is elevated in the airway epithelium in asthma; however, the contribution of uPAR to asthma pathogenesis and scope for therapeutic targeting remains unknown. Object
Externí odkaz:
https://doaj.org/article/b98b2138b6a345bba5e4c156f9115f19
Autor:
Sangita Bhaker, Michael A. Portelli, Kamini Rakkar, Dominick Shaw, Simon Johnson, Christopher Brightling, Ian Sayers
Publikováno v:
ERJ Open Research, Vol 8, Iss 1 (2022)
Externí odkaz:
https://doaj.org/article/ddb2c536e99642c9b3bab43b9ceb0b9b
Publikováno v:
Frontiers in Allergy, Vol 2 (2021)
Asthma affects more than 300 million people globally and is both under diagnosed and under treated. The most recent and largest genome-wide association study investigating moderate to severe asthma to date was carried out in 2019 and identified 25 in
Externí odkaz:
https://doaj.org/article/a8b1f2f2ce564bd298a06dd51d171aed
Autor:
Jonathan O'Loughlin, Robert J. Hall, Sangita Bhaker, Michael A. Portelli, Amanda Henry, Vincent Pang, David O. Bates, Tyson V. Sharp, Ian Sayers
Publikováno v:
ERJ Open Research, Vol 7, Iss 1 (2021)
Genetic studies have identified several epithelial-derived genes associated with airway diseases. However, techniques used to study gene function frequently exceed the proliferative potential of primary human bronchial epithelial cells (HBECs) isolat
Externí odkaz:
https://doaj.org/article/3c3cfae19b254f35bbc5345f4b26032c
Autor:
Louise V Wain, Ian Sayers, María Soler Artigas, Michael A Portelli, Eleftheria Zeggini, Ma'en Obeidat, Don D Sin, Yohan Bossé, David Nickle, Corry-Anke Brandsma, Anders Malarstig, Ciara Vangjeli, Scott A Jelinsky, Sally John, Iain Kilty, Tricia McKeever, Nick R G Shrine, James P Cook, Shrina Patel, Tim D Spector, Edward J Hollox, Ian P Hall, Martin D Tobin
Publikováno v:
PLoS Genetics, Vol 10, Iss 5, p e1004314 (2014)
Chronic obstructive pulmonary disease (COPD) is a leading cause of global morbidity and mortality and, whilst smoking remains the single most important risk factor, COPD risk is heritable. Of 26 independent genomic regions showing association with lu
Externí odkaz:
https://doaj.org/article/80130c5b7ffc455eaf146a6e0dad6b17