Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Melissa Sorosina"'
Autor:
Majid Pahlevan Kakhki, Antonino Giordano, Chiara Starvaggi Cucuzza, Tejaswi Venkata S. Badam, Samudyata Samudyata, Marianne Victoria Lemée, Pernilla Stridh, Asimenia Gkogka, Klementy Shchetynsky, Adil Harroud, Alexandra Gyllenberg, Yun Liu, Sanjaykumar Boddul, Tojo James, Melissa Sorosina, Massimo Filippi, Federica Esposito, Fredrik Wermeling, Mika Gustafsson, Patrizia Casaccia, Jan Hillert, Tomas Olsson, Ingrid Kockum, Carl M. Sellgren, Christelle Golzio, Lara Kular, Maja Jagodic
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Multiple Sclerosis (MS) is a heterogeneous inflammatory and neurodegenerative disease with an unpredictable course towards progressive disability. Treating progressive MS is challenging due to limited insights into the underlying mechanisms.
Externí odkaz:
https://doaj.org/article/335891136a424c99812fda12c3ca1d91
Autor:
Federica Cerri, Francesco Gentile, Ferdinando Clarelli, Silvia Santoro, Yuri Matteo Falzone, Giorgia Dina, Alessandro Romano, Teuta Domi, Laura Pozzi, Raffaella Fazio, Paola Podini, Melissa Sorosina, Paola Carrera, Federica Esposito, Nilo Riva, Chiara Briani, Tiziana Cavallaro, Massimo Filippi, Angelo Quattrini
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Although inflammation appears to play a role in neurolymphomatosis (NL), the mechanisms leading to degeneration in the peripheral nervous system are poorly understood. The purpose of this exploratory study was to identify molecular pathways underlyin
Externí odkaz:
https://doaj.org/article/cc6f17e7176d4a779b5afbb6b7aa98d8
Autor:
Laura Ferrè, Ferdinando Clarelli, Beatrice Pignolet, Elisabetta Mascia, Marco Frasca, Silvia Santoro, Melissa Sorosina, Florence Bucciarelli, Lucia Moiola, Vittorio Martinelli, Giancarlo Comi, Roland Liblau, Massimo Filippi, Giorgio Valentini, Federica Esposito
Publikováno v:
Journal of Personalized Medicine, Vol 13, Iss 1, p 122 (2023)
A personalized approach is strongly advocated for treatment selection in Multiple Sclerosis patients due to the high number of available drugs. Machine learning methods proved to be valuable tools in the context of precision medicine. In the present
Externí odkaz:
https://doaj.org/article/40d6494178a44d79946a356072c44271
Autor:
Federica Esposito, Ana Maria Osiceanu, Melissa Sorosina, Linda Ottoboni, Bryan Bollman, Silvia Santoro, Barbara Bettegazzi, Andrea Zauli, Ferdinando Clarelli, Elisabetta Mascia, Andrea Calabria, Daniele Zacchetti, Ruggero Capra, Maurizio Ferrari, Paolo Provero, Dejan Lazarevic, Davide Cittaro, Paola Carrera, Nikolaos Patsopoulos, Daniela Toniolo, A Dessa Sadovnick, Gianvito Martino, Philip L. De Jager, Giancarlo Comi, Elia Stupka, Carles Vilariño-Güell, Laura Piccio, Filippo Martinelli Boneschi
Publikováno v:
Genes, Vol 13, Iss 12, p 2392 (2022)
While the role of common genetic variants in multiple sclerosis (MS) has been elucidated in large genome-wide association studies, the contribution of rare variants to the disease remains unclear. Herein, a whole-genome sequencing study in four affec
Externí odkaz:
https://doaj.org/article/aa75b5f0e022400d8776f2e35d6e26ac
Autor:
Antonino Giordano, Ferdinando Clarelli, Miryam Cannizzaro, Elisabetta Mascia, Silvia Santoro, Melissa Sorosina, Laura Ferrè, Letizia Leocani, Federica Esposito
Publikováno v:
Frontiers in Neurology, Vol 13 (2022)
BackgroundRehabilitation is fundamental for progressive multiple sclerosis (MS), but predictive biomarkers of motor recovery are lacking, making patient selection difficult. Motor recovery depends on synaptic plasticity, in which the Brain-Derived Ne
Externí odkaz:
https://doaj.org/article/1dd0df52c2e24cecafadb5d361367f7e
Autor:
Ferdinando Clarelli, Nadia Barizzone, Eleonora Mangano, Miriam Zuccalà, Chiara Basagni, Santosh Anand, Melissa Sorosina, Elisabetta Mascia, Silvia Santoro, PROGEMUS, PROGRESSO, Franca Rosa Guerini, Eleonora Virgilio, Antonio Gallo, Alessandro Pizzino, Cristoforo Comi, Vittorio Martinelli, Giancarlo Comi, Gianluca De Bellis, Maurizio Leone, Massimo Filippi, Federica Esposito, Roberta Bordoni, Filippo Martinelli Boneschi, Sandra D'Alfonso, P Crociani, D Vecchio, P Ragonese, A Gajofatto, E Scarpini, A Bertolotto, D Caputo, C Gasperini, F Granella, S Cordera, P Cavallo, R Cavallo, R Bergamaschi, G Ristori, C Solaro, F Martinelli, F Passantino, M Pugliatti, A Gallo, L Brambilla, C Clerico, F Capone, F Esposito, G Liberatore, M Rodegher, p Rossi, M Radaelli, L Moiola, B Colombo, A Ghezzi, A Annovazzi, R Capra, G Coniglio, M. P Amato, B Nacmias, G Tedeschi, A D’Ambrosio, P Cavalla, F Patti, E D’Amico, D Galimberti, P Gallo, M Atzori, L Grimaldi, S Bucello, G Mancardi, E Capello
Publikováno v:
Frontiers in Genetics, Vol 12 (2022)
Genome-wide association studies identified over 200 risk loci for multiple sclerosis (MS) focusing on common variants, which account for about 50% of disease heritability. The goal of this study was to investigate whether low-frequency and rare funct
Externí odkaz:
https://doaj.org/article/68d0393bd32c4e15a1437e3e4fc9a308
Autor:
Melissa Sorosina, Silvia Peroni, Elisabetta Mascia, Silvia Santoro, Ana Maria Osiceanu, Laura Ferrè, Ferdinando Clarelli, Antonino Giordano, Miryam Cannizzaro, Filippo Martinelli Boneschi, Massimo Filippi, Federica Esposito
Publikováno v:
Genes, Vol 13, Iss 11, p 1946 (2022)
Multiple sclerosis (MS) is an inflammatory neurodegenerative disorder of the central nervous system (CNS). The migration of immune cells into the CNS is essential for its development, and plasma membrane molecules play an important role in triggering
Externí odkaz:
https://doaj.org/article/e359cdf76fcf472c8920a07d12598242
Autor:
Nadia Barizzone, Rachele Cagliani, Chiara Basagni, Ferdinando Clarelli, Laura Mendozzi, Cristina Agliardi, Diego Forni, Martina Tosi, Elisabetta Mascia, Francesco Favero, Davide Corà, Lucia Corrado, Melissa Sorosina, Federica Esposito, Miriam Zuccalà, Domizia Vecchio, Maria Liguori, Cristoforo Comi, Giancarlo Comi, Vittorio Martinelli, Massimo Filippi, Maurizio Leone, Filippo Martinelli-Boneschi, Domenico Caputo, Manuela Sironi, Franca Rosa Guerini, Sandra D’Alfonso
Publikováno v:
Genes, Vol 12, Iss 10, p 1607 (2021)
Known multiple sclerosis (MS) susceptibility variants can only explain half of the disease’s estimated heritability, whereas low-frequency and rare variants may partly account for the missing heritability. Thus, here we sought to determine the occu
Externí odkaz:
https://doaj.org/article/ce9bdd4fc838408580ea93cf8dcaa66c
Autor:
Michela Riba, Marco Rausa, Melissa Sorosina, Davide Cittaro, Jose Manuel Garcia Manteiga, Antonella Nai, Alessia Pagani, Filippo Martinelli-Boneschi, Elia Stupka, Clara Camaschella, Laura Silvestri
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e69694 (2013)
Control of systemic iron homeostasis is interconnected with the inflammatory response through the key iron regulator, the antimicrobial peptide hepcidin. We have previously shown that mice with iron deficiency anemia (IDA)-low hepcidin show a pro-inf
Externí odkaz:
https://doaj.org/article/0ed9bab55f9141e189ba62a2958b3215