Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Matthew R. Sarkisian"'
Autor:
Jia Tian, Julianne C. Mallinger, Ping Shi, Dahao Ling, Loic P. Deleyrolle, Min Lin, Habibeh Khoshbouei, Matthew R. Sarkisian
Publikováno v:
Translational Oncology, Vol 45, Iss , Pp 101956- (2024)
Tumor Treating Fields (TTFields) extend the survival of glioblastoma (GBM) patients by interfering with a broad range of tumor cellular processes. Among these, TTFields disrupt primary cilia stability on GBM cells. Here we asked if concomitant treatm
Externí odkaz:
https://doaj.org/article/57ef9904b530417fbe1d5d0a9438b3c5
Autor:
Avirup Chakraborty, Changlin Yang, Jesse L. Kresak, Aryeh J. Silver, Diana Feier, Guimei Tian, Michael Andrews, Olusegun O. Sobanjo, Ethan D. Hodge, Mia K. Engelbart, Jianping Huang, Jeffrey K. Harrison, Matthew R. Sarkisian, Duane A. Mitchell, Loic P. Deleyrolle
Publikováno v:
Cells, Vol 13, Iss 11, p 938 (2024)
Glioblastoma (GBM) poses a significant challenge in clinical oncology due to its aggressive nature, heterogeneity, and resistance to therapies. Cancer stem cells (CSCs) play a critical role in GBM, particularly in treatment resistance and tumor relap
Externí odkaz:
https://doaj.org/article/da408b0d9d444c89803182abab76b701
Autor:
Ping Shi, Jia Tian, Julianne C. Mallinger, Dahao Ling, Loic P. Deleyrolle, Jeremy C. McIntyre, Tamara Caspary, Joshua J. Breunig, Matthew R. Sarkisian
Publikováno v:
Cells, Vol 12, Iss 19, p 2354 (2023)
ADP-ribosylation factor-like protein 13B (ARL13B), a regulatory GTPase and guanine exchange factor (GEF), enriches in primary cilia and promotes tumorigenesis in part by regulating Smoothened (SMO), GLI, and Sonic Hedgehog (SHH) signaling. Gliomas wi
Externí odkaz:
https://doaj.org/article/4ecbb8232b484655acc6682a38159c39
Autor:
Derrick Lee, Ryan C. Gimple, Xujia Wu, Briana C. Prager, Zhixin Qiu, Qiulian Wu, Vikas Daggubati, Aruljothi Mariappan, Jay Gopalakrishnan, Matthew R. Sarkisian, David R. Raleigh, Jeremy N. Rich
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 2 (2023)
Glioblastoma ranks among the most aggressive and lethal of all human cancers. Self-renewing, highly tumorigenic glioblastoma stem cells (GSCs) contribute to therapeutic resistance and maintain cellular heterogeneity. Here, we interrogated superenhanc
Externí odkaz:
https://doaj.org/article/9e622da572424f9dad2fb6932cf79adc
Autor:
Aryeh Silver, Diana Feier, Tanya Ghosh, Maryam Rahman, Jianping Huang, Matthew R. Sarkisian, Loic P. Deleyrolle
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Glioblastoma (GBM) is an extremely aggressive and incurable primary brain tumor with a 10-year survival of just 0.71%. Cancer stem cells (CSCs) are thought to seed GBM’s inevitable recurrence by evading standard of care treatment, which combines su
Externí odkaz:
https://doaj.org/article/b0550e6abb3645d3a710da99f2c75400
Autor:
Ping Shi, Jia Tian, Brittany S. Ulm, Julianne C. Mallinger, Habibeh Khoshbouei, Loic P. Deleyrolle, Matthew R. Sarkisian
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Tumor Treating Fields (TTFields) are low-intensity, alternating intermediate-frequency (200 kHz) electrical fields that extend survival of glioblastoma patients receiving maintenance temozolomide (TMZ) chemotherapy. How TTFields exert efficacy on can
Externí odkaz:
https://doaj.org/article/d1e904d203374f5fb7fb461f51554571
Autor:
Changlin Yang, Guimei Tian, Mariana Dajac, Andria Doty, Shu Wang, Ji-Hyun Lee, Maryam Rahman, Jianping Huang, Brent A. Reynolds, Matthew R. Sarkisian, Duane Mitchell, Loic P. Deleyrolle
Publikováno v:
Cancers, Vol 14, Iss 5, p 1126 (2022)
Glioblastoma (GBM) exhibits populations of cells that drive tumorigenesis, treatment resistance, and disease progression. Cells with such properties have been described to express specific surface and intracellular markers or exhibit specific functio
Externí odkaz:
https://doaj.org/article/76f70c18b5a44ac4afe5e1858ff59821
Autor:
Ping Shi, Lan B. Hoang-Minh, Jia Tian, Alice Cheng, Reemsha Basrai, Neil Kalaria, Joseph J. Lebowitz, Habibeh Khoshbouei, Loic P. Deleyrolle, Matthew R. Sarkisian
Publikováno v:
Cancers, Vol 13, Iss 7, p 1644 (2021)
Histone deacetylase 6 (HDAC6) is an emerging therapeutic target that is overexpressed in glioblastoma when compared to other HDACs. HDAC6 catalyzes the deacetylation of alpha-tubulin and mediates the disassembly of primary cilia, a process required f
Externí odkaz:
https://doaj.org/article/9023ab8f0c9b48fbb58cd041f0eec26f
Autor:
Lan B. Hoang-Minh, Loic P. Deleyrolle, Nariaki S. Nakamura, Alexander K. Parker, Regina T. Martuscello, Brent A. Reynolds, Matthew R. Sarkisian
Publikováno v:
Translational Oncology, Vol 9, Iss 5, Pp 392-402 (2016)
A better understanding of the molecules implicated in the growth and survival of glioblastoma (GBM) cells and their response to temozolomide (TMZ), the standard-of-care chemotherapeutic agent, is necessary for the development of new therapies that wo
Externí odkaz:
https://doaj.org/article/0448ad1adf4345f38f4046a08d3d0d39
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 13 (2019)
Primary cilia are microtubule-based organelles that are typically present on cells during the G0 or G1-S/G2 phases of the cell cycle. Recent studies of glioblastoma (GBM) biopsies, a brain tumor that is notorious for its aggressive growth and resista
Externí odkaz:
https://doaj.org/article/876184e16ddf4cd3861ca68770b57d7b