Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Leandro Cerchietti"'
Autor:
Luca Vincenzo Cappelli, Danilo Fiore, Liu Zhaoqi, Nikita Kotlov, Jude Phillip, Paul Zumbo, Liron Yoffe, Claudia Pignataro, Paola Ghione, Han Xueshuai, Valentina Fragliasso, Gerolama Condorelli, Robin Foà, Joshua Brody, Doron Betel, John Chan, Wayne Tam, David Weinstock, Leandro Cerchietti, Raul Rabadan, Steven Horwitz, Giorgio Inghirami
Publikováno v:
HemaSphere, Vol 7, p e58193ee (2023)
Externí odkaz:
https://doaj.org/article/7d2660d378924dc28b6db15624027e3e
Autor:
Danilo Fiore, Luca Vincenzo Cappelli, Liu Zhaoqi, Nikita Kotlov, Maria Sorokina, Jude Phillip, Paul Zumbo, Liron Yoffe, Han Xueshuai, Claudia Pignataro, Paola Ghione, Valentina Fragliasso, Gerolama Condorelli, Robin Foà, Joshua Brody, Doron Betel, Wing C Chan, Wayne Tam, Anastasie Nikitina, Aleksander Bagaev, Nathan Fowler, David Weinstock, Leandro Cerchietti, Raul Rabadan, Steve Horwitz, Giorgio Inghirami
Publikováno v:
HemaSphere, Vol 7, p e8686389 (2023)
Externí odkaz:
https://doaj.org/article/ac0ba3f3a2254b25bcc9944460c428ab
Autor:
Daniel P. Gomari, Annalise Schweickart, Leandro Cerchietti, Elisabeth Paietta, Hugo Fernandez, Hassen Al-Amin, Karsten Suhre, Jan Krumsiek
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-9 (2022)
Variable autoencoders offer an alternative way to interrogate metabolomic data and identify meaningful, non-linear relationships.
Externí odkaz:
https://doaj.org/article/3961c9d5fe67404480bd95c5c6999ff4
Autor:
Sara Napoli, Luciano Cascione, Andrea Rinaldi, Filippo Spriano, Francesca Guidetti, Fangwen Zhang, Maria Teresa Cacciapuoti, Afua Adjeiwaa Mensah, Giulio Sartori, Nicolas Munz, Mattia Forcato, Silvio Bicciato, Annalisa Chiappella, Paola Ghione, Olivier Elemento, Leandro Cerchietti, Giorgio Inghirami, Francesco Bertoni
Publikováno v:
Haematologica, Vol 107, Iss 5 (2021)
Enhancers are regulatory regions of DNA, which play a key role in cell-type specific differentiation and development. Most active enhancers are transcribed into enhancer RNA (eRNA) that can regulate transcription of target genes by means of in cis as
Externí odkaz:
https://doaj.org/article/02d6451c7ad247069c6f35a584210239
Autor:
Mariángeles Clauzure, Mónica A. Táquez Delgado, Jude M. Phillip, Maria V. Revuelta, Leandro Cerchietti, Vanina A. Medina
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 3, p 1378 (2022)
The discovery of the human histamine H4 receptor (H4R) has contributed to our understanding of the role of histamine in numerous physiological and pathological conditions, including tumor development and progression. The lymph nodes of patients with
Externí odkaz:
https://doaj.org/article/37143af6fc1b490b9610f63f687828b1
Autor:
Shira Yomtoubian, Sharrell B. Lee, Akanksha Verma, Franco Izzo, Geoffrey Markowitz, Hyejin Choi, Leandro Cerchietti, Linda Vahdat, Kristy A. Brown, Eleni Andreopoulou, Olivier Elemento, Jenny Chang, Giorgio Inghirami, Dingcheng Gao, Seongho Ryu, Vivek Mittal
Publikováno v:
Cell Reports, Vol 30, Iss 3, Pp 755-770.e6 (2020)
Summary: Epigenetic changes are increasingly being appreciated as key events in breast cancer progression. However, breast cancer subtype-specific epigenetic regulation remains poorly investigated. Here we report that EZH2 is a leading candidate of e
Externí odkaz:
https://doaj.org/article/dc5eae5543644a968ae0a2033cf31557
Autor:
Benet Pera, Jan Krumsiek, Sarit E. Assouline, Rossella Marullo, Jayeshkumar Patel, Jude M. Phillip, Lidia Román, Koren K. Mann, Leandro Cerchietti
Publikováno v:
EBioMedicine, Vol 28, Iss C, Pp 80-89 (2018)
Despite the proven clinical antineoplastic activity of histone deacetylase inhibitors (HDACI), their effect has been reported to be lower than expected in B-cell lymphomas. Traditionally considered as “epigenetic drugs”, HDACI modify the acetylat
Externí odkaz:
https://doaj.org/article/70c266c93da24d23921073b49e235d89
Autor:
Florencia Cayrol, Pannee Praditsuktavorn, Tharu M. Fernando, Nicholas Kwiatkowski, Rosella Marullo, M. Nieves Calvo-Vidal, Jude Phillip, Benet Pera, Shao Ning Yang, Kaipol Takpradit, Lidia Roman, Marcello Gaudiano, Ramona Crescenzo, Jia Ruan, Giorgio Inghirami, Tinghu Zhang, Graciela Cremaschi, Nathanael S. Gray, Leandro Cerchietti
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
T-cell lymphomas are aggressive diseases associated with poor outcome. Here, the authors show that the THZ1, a CDK7 inhibitor, suppresses STAT transcriptional activity leading to apoptosis and sensitization to BCL2 inhibitors in T-cell lymphomas.
Externí odkaz:
https://doaj.org/article/d9b0eca4497a40c1b2e964a28298864d
Autor:
Danilo Fiore, Luca Vincenzo Cappelli, Paul Zumbo, Jude M. Phillips, Zhaoqi Liu, Shuhua Cheng, Liron Yoffe, Paola Ghione, Federica Di Maggio, Ahmet Dogan, Inna Khodos, Elisa de Stanchina, Joseph Casano, Clarisse Kayembe, Wayne Tam, Doron Betel, Robin Foa’, Leandro Cerchietti, Raul Rabadan, Steven Horwitz, David M. Weinstock, Giorgio Inghirami
Publikováno v:
Cancers, Vol 12, Iss 6, p 1603 (2020)
Breast implant-associated lymphoma (BIA-ALCL) has recently been recognized as an independent peripheral T-cell lymphoma (PTCL) entity. In this study, we generated the first BIA-ALCL patient-derived tumor xenograft (PDTX) model (IL89) and a matching c
Externí odkaz:
https://doaj.org/article/6958d3085d5c47fdba82781ea47c3692
Autor:
Katerina Hatzi, Yanwen Jiang, Chuanxin Huang, Francine Garrett-Bakelman, Micah D. Gearhart, Eugenia G. Giannopoulou, Paul Zumbo, Kevin Kirouac, Srividya Bhaskara, Jose M. Polo, Matthias Kormaksson, Alexander D. MacKerell, Jr., Fengtian Xue, Christopher E. Mason, Scott W. Hiebert, Gilbert G. Prive, Leandro Cerchietti, Vivian J. Bardwell, Olivier Elemento, Ari Melnick
Publikováno v:
Cell Reports, Vol 4, Iss 3, Pp 578-588 (2013)
The BCL6 transcriptional repressor is required for the development of germinal center (GC) B cells and diffuse large B cell lymphomas (DLBCLs). Although BCL6 can recruit multiple corepressors, its transcriptional repression mechanism of action in nor
Externí odkaz:
https://doaj.org/article/9cd7d9fe59494c7fbf2a87fbc864e290