Zobrazeno 1 - 5
of 5
pro vyhledávání: '"John G. Lock"'
Autor:
Ensieh M. Poursani, Daniele Mercatelli, Prahlad Raninga, Jessica L. Bell, Federica Saletta, Felix V. Kohane, Daniel P. Neumann, Ye Zheng, Jourdin R. C. Rouaen, Toni Rose Jue, Filip T. Michniewicz, Piper Schadel, Erin Kasiou, Maria Tsoli, Giuseppe Cirillo, Shafagh Waters, Tyler Shai-Hee, Riccardo Cazzoli, Merryn Brettle, Iveta Slapetova, Maria Kasherman, Renee Whan, Fernando Souza-Fonseca-Guimaraes, Linda Vahdat, David Ziegler, John G. Lock, Federico M. Giorgi, KumKum Khanna, Orazio Vittorio
Publikováno v:
Cell & Bioscience, Vol 13, Iss 1, Pp 1-19 (2023)
Abstract Background Metastatic cancer cells exploit Epithelial-mesenchymal-transition (EMT) to enhance their migration, invasion, and resistance to treatments. Recent studies highlight that elevated levels of copper are implicated in cancer progressi
Externí odkaz:
https://doaj.org/article/b17391f9a29d4891bcdc6914896812f8
Autor:
Tanzila Khan, John G. Lock, Yafeng Ma, David G. Harman, Paul de Souza, Wei Chua, Bavanthi Balakrishnar, Kieran F. Scott, Therese M. Becker
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-9 (2022)
Abstract Androgen receptor variant 7 (AR-V7) is an important biomarker to guide treatment options for castration-resistant prostate cancer (CRPC) patients. Its detectability in circulating tumour cells (CTCs) opens non-invasive diagnostic avenues. Wh
Externí odkaz:
https://doaj.org/article/d06bbbb8a6c34c748da9fb0465a71580
Autor:
John G Lock, Mehrdad Jafari Mamaghani, Hamdah Shafqat-Abbasi, Xiaowei Gong, Joanna Tyrcha, Staffan Strömblad
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e90593 (2014)
Heterogeneous and dynamic single cell migration behaviours arise from a complex multi-scale signalling network comprising both molecular components and macromolecular modules, among which cell-matrix adhesions and F-actin directly mediate migration.
Externí odkaz:
https://doaj.org/article/8242f4a16cd14b78a414665ea4073b58
Autor:
Hamdah Shafqat-Abbasi, Jacob M Kowalewski, Alexa Kiss, Xiaowei Gong, Pablo Hernandez-Varas, Ulrich Berge, Mehrdad Jafari-Mamaghani, John G Lock, Staffan Strömblad
Publikováno v:
eLife, Vol 5 (2016)
Mesenchymal (lamellipodial) migration is heterogeneous, although whether this reflects progressive variability or discrete, 'switchable' migration modalities, remains unclear. We present an analytical toolbox, based on quantitative single-cell imagin
Externí odkaz:
https://doaj.org/article/aaf754e3057d48ffaa4e2c52ae0bf92a
Autor:
Jacob M Kowalewski, Hamdah Shafqat-Abbasi, Mehrdad Jafari-Mamaghani, Bereket Endrias Ganebo, Xiaowei Gong, Staffan Strömblad, John G Lock
Publikováno v:
PLoS ONE, Vol 10, Iss 8, p e0135204 (2015)
Cell migration is heavily interconnected with plasma membrane protrusion and retraction (collectively termed "membrane dynamics"). This makes it difficult to distinguish regulatory mechanisms that differentially influence migration and membrane dynam
Externí odkaz:
https://doaj.org/article/615fb33eb9b144b196d08ccd25d0fe8c