Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Geethu E. Thomas"'
Autor:
Samir H. Barghout, Ahmed Aman, Kazem Nouri, Zachary Blatman, Karen Arevalo, Geethu E. Thomas, Neil MacLean, Rose Hurren, Troy Ketela, Mehakpreet Saini, Moustafa Abohawya, Taira Kiyota, Rima Al-Awar, Aaron D. Schimmer
Publikováno v:
JCI Insight, Vol 6, Iss 5 (2021)
TAK-243 is a first-in-class inhibitor of ubiquitin-like modifier activating enzyme 1 that catalyzes ubiquitin activation, the first step in the ubiquitylation cascade. Based on its preclinical efficacy and tolerability, TAK-243 has been advanced to p
Externí odkaz:
https://doaj.org/article/d082e4930596459b8898e21f8ca1f16d
Autor:
Aaron D. Schimmer, Rashim Pal Singh, Ayesh K. Seneviratne, Geethu E. Thomas, Neil MacLean, Rose Hurren
Publikováno v:
STAR Protocols, Vol 1, Iss 3, Pp 100163- (2020)
Summary: We describe a method to silence genes in primary acute myeloid leukemia cells by transducing them with shRNA in lentiviral vectors. The transduction of primary non-adherent cells is particularly challenging. The protocol will aid in performi
Externí odkaz:
https://doaj.org/article/271c6333c8a0432cbe81361b90838f2e
Autor:
Geethu E. Thomas, K. Bandopadhyay, Sabyasachi Sutradhar, M. R. Renjith, Puja Singh, K. K. Gireesh, Steny Simon, Binshad Badarudeen, Hindol Gupta, Manidipa Banerjee, Raja Paul, J. Mitra, Tapas K. Manna
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
Ska1 is a kinetochore-localised protein that couples kinetochore movement to microtubule (MT) depolymerisation. Here Thomas et al. show that the MT +TIP binding protein EB1 recruits Ska1 to the MT-kinetochore interface and stabilises the interaction
Externí odkaz:
https://doaj.org/article/f53440769de3492a93c9e28514a15bd5