Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Gavin Ha"'
Autor:
Azra Ajkunic, Erolcan Sayar, Martine P. Roudier, Radhika A. Patel, Ilsa M. Coleman, Navonil De Sarkar, Brian Hanratty, Mohamed Adil, Jimmy Zhao, Samir Zaidi, Lawrence D. True, Jamie M. Sperger, Heather H. Cheng, Evan Y. Yu, Robert B. Montgomery, Jessica E. Hawley, Gavin Ha, Thomas Persse, Patricia Galipeau, John K. Lee, Stephanie A. Harmon, Eva Corey, Joshua M. Lang, Charles L. Sawyers, Colm Morrissey, Michael T. Schweizer, Roman Gulati, Peter S. Nelson, Michael C. Haffner
Publikováno v:
npj Precision Oncology, Vol 8, Iss 1, Pp 1-9 (2024)
Abstract Therapeutic approaches targeting proteins on the surface of cancer cells have emerged as an important strategy for precision oncology. To capitalize on the potential impact of drugs targeting surface proteins, detailed knowledge about the ex
Externí odkaz:
https://doaj.org/article/cdd085eaf0e84556a25f843f3b873e3c
Autor:
Yaping Liu, Sarah C. Reed, Christopher Lo, Atish D. Choudhury, Heather A. Parsons, Daniel G. Stover, Gavin Ha, Gregory Gydush, Justin Rhoades, Denisse Rotem, Samuel Freeman, David W. Katz, Ravi Bandaru, Haizi Zheng, Hailu Fu, Viktor A. Adalsteinsson, Manolis Kellis
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-9 (2024)
Abstract Analysis of DNA methylation in cell-free DNA reveals clinically relevant biomarkers but requires specialized protocols such as whole-genome bisulfite sequencing. Meanwhile, millions of cell-free DNA samples are being profiled by whole-genome
Externí odkaz:
https://doaj.org/article/2651db1b0e8b4f7bb0bfb12f96123920
Autor:
Anna-Lisa Doebley, Minjeong Ko, Hanna Liao, A. Eden Cruikshank, Katheryn Santos, Caroline Kikawa, Joseph B. Hiatt, Robert D. Patton, Navonil De Sarkar, Katharine A. Collier, Anna C. H. Hoge, Katharine Chen, Anat Zimmer, Zachary T. Weber, Mohamed Adil, Jonathan B. Reichel, Paz Polak, Viktor A. Adalsteinsson, Peter S. Nelson, David MacPherson, Heather A. Parsons, Daniel G. Stover, Gavin Ha
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Nucleosome profiling from cell-free DNA (cfDNA) represents a potential approach for cancer detection and classification. Here, the authors develop Griffin, a computational framework for tumour subtype classification based on cfDNA nucleosome profilin
Externí odkaz:
https://doaj.org/article/a2aa19ff06af40648abe298b2dc9bb6b
Autor:
Samantha L. Schuster, Sonali Arora, Cynthia L. Wladyka, Pushpa Itagi, Lukas Corey, Dave Young, Bethany L. Stackhouse, Lori Kollath, Qian V. Wu, Eva Corey, Lawrence D. True, Gavin Ha, Patrick J. Paddison, Andrew C. Hsieh
Publikováno v:
Cell Reports, Vol 42, Iss 8, Pp 112840- (2023)
Summary: 3′ untranslated region (3′ UTR) somatic mutations represent a largely unexplored avenue of alternative oncogenic gene dysregulation. To determine the significance of 3′ UTR mutations in disease, we identify 3′ UTR somatic variants ac
Externí odkaz:
https://doaj.org/article/8788ab3aff1444089f1efea108c27405
Publikováno v:
European Journal of Case Reports in Internal Medicine (2023)
Introduction: Multicentric Castleman disease (MCD) is a lymphoproliferative disorder characterized by lymph node histopathology and systemic symptoms. To our knowledge, there are no descriptions in the literature of long-term outcomes of human herpes
Externí odkaz:
https://doaj.org/article/353d6f4d0f7840a78117312b1ba1dac6
Autor:
Anna C. H. Hoge, Michal Getz, Anat Zimmer, Minjeong Ko, Linoy Raz, Rameen Beroukhim, Todd R. Golub, Gavin Ha, Uri Ben David
Publikováno v:
npj Precision Oncology, Vol 6, Iss 1, Pp 1-7 (2022)
Abstract Genomic evolution of patient-derived xenografts (PDXs) may lead to their gradual divergence away of their tumors of origin. We previously reported the genomic evolution of the copy number (CN) landscapes of PDXs during their engraftment and
Externí odkaz:
https://doaj.org/article/0ee932769b144f99adb5cd6d33e0312c
Autor:
Samuel Terkper Ahuno, Anna-Lisa Doebley, Thomas U. Ahearn, Joel Yarney, Nicholas Titiloye, Nancy Hamel, Ernest Adjei, Joe-Nat Clegg-Lamptey, Lawrence Edusei, Baffour Awuah, Xiaoyu Song, Verna Vanderpuye, Mustapha Abubakar, Maire Duggan, Daniel G. Stover, Kofi Nyarko, John M. S. Bartlett, Francis Aitpillah, Daniel Ansong, Kevin L. Gardner, Felix Andy Boateng, Anne M. Bowcock, Carlos Caldas, William D. Foulkes, Seth Wiafe, Beatrice Wiafe-Addai, Montserrat Garcia-Closas, Alexander Kwarteng, Gavin Ha, Jonine D. Figueroa, Paz Polak, the Ghana Breast Health Study Team
Publikováno v:
npj Precision Oncology, Vol 5, Iss 1, Pp 1-8 (2021)
Abstract Circulating tumor DNA (ctDNA) sequencing studies could provide novel insights into the molecular pathology of cancer in sub-Saharan Africa. In 15 patient plasma samples collected at the time of diagnosis as part of the Ghana Breast Health St
Externí odkaz:
https://doaj.org/article/0fd72a4af12c4bc4bb78096b172d0185
Autor:
Meng Zhou, Minjeong Ko, Anna C.H. Hoge, Kelsey Luu, Yuzhen Liu, Magdalena L. Russell, William W. Hannon, Zhenwei Zhang, Jian Carrot-Zhang, Rameen Beroukhim, Eliezer M. Van Allen, Atish D. Choudhury, Peter S. Nelson, Matthew L. Freedman, Mary-Ellen Taplin, Matthew Meyerson, Srinivas R. Viswanathan, Gavin Ha
Publikováno v:
JCI Insight, Vol 7, Iss 17 (2022)
The complex genomic landscape of prostate cancer evolves across disease states under therapeutic pressure directed toward inhibiting androgen receptor (AR) signaling. While significantly altered genes in prostate cancer have been extensively defined,
Externí odkaz:
https://doaj.org/article/6032eee655da4206a5a620a0aa119445
Autor:
Kar-Tong Tan, Hyunji Kim, Jian Carrot-Zhang, Yuxiang Zhang, Won Jun Kim, Guillaume Kugener, Jeremiah A. Wala, Thomas P. Howard, Yueh-Yun Chi, Rameen Beroukhim, Heng Li, Gavin Ha, Seth L. Alper, Elizabeth J. Perlman, Elizabeth A. Mullen, William C. Hahn, Matthew Meyerson, Andrew L. Hong
Publikováno v:
Genome Medicine, Vol 13, Iss 1, Pp 1-13 (2021)
Abstract Background Renal medullary carcinomas (RMCs) are rare kidney cancers that occur in adolescents and young adults of African ancestry. Although RMC is associated with the sickle cell trait and somatic loss of the tumor suppressor, SMARCB1, the
Externí odkaz:
https://doaj.org/article/500d30bc4a054d33b395ec98271cf7b5
Autor:
Yiting Lim, Sonali Arora, Samantha L. Schuster, Lukas Corey, Matthew Fitzgibbon, Cynthia L. Wladyka, Xiaoying Wu, Ilsa M. Coleman, Jeffrey J. Delrow, Eva Corey, Lawrence D. True, Peter S. Nelson, Gavin Ha, Andrew C. Hsieh
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Mutations in 5’ untranslated regions (UTRs) have a functional role in gene expression in cancer. Here, the authors develop a sequencing-based high throughput functional assay named PLUMAGE and show the effects of these mutations on gene expression
Externí odkaz:
https://doaj.org/article/b09e659db3294cf0bec903efcd4f8344