Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Eun La Kim"'
Publikováno v:
Marine Drugs, Vol 20, Iss 3, p 203 (2022)
Through activity-guided fractionation, a new triterpene (asperflagin, 1) was isolated as a PPAR-γ agonist from the jellyfish-derived fungus Aspergillus flavus. Asperflagin displayed selective and moderate transactivation effects on PPAR-γ in Ac2F r
Externí odkaz:
https://doaj.org/article/2f9485ee2a7847ff902f8ac27540733b
Publikováno v:
Marine Drugs, Vol 19, Iss 8, p 417 (2021)
Peroxisome proliferator-activated receptor (PPAR) expression has been implicated in pathological states such as cancer, inflammation, diabetes, and neurodegeneration. We isolated natural PPAR agonists—eight 2,5-diketopiperazines—from the jellyfis
Externí odkaz:
https://doaj.org/article/0303618d71c54fe78a2c00beb0c666e5
Autor:
Mingzhi Su, Changhao Zhao, Dandan Li, Jiafu Cao, Zhiran Ju, Eun La Kim, Young-Suk Jung, Jee H. Jung
Publikováno v:
Marine Drugs, Vol 18, Iss 9, p 445 (2020)
Microtubules play a crucial role in mitosis and are attractive targets for cancer therapy. Recently, we isolated viriditoxin, a cytotoxic and antibacterial compound, from a marine fungus Paecilomyces variotii. Viriditoxin has been reported to inhibit
Externí odkaz:
https://doaj.org/article/0b6adde330414953b3d3742de1bc70a7
Autor:
Bin Xiao, Mingzhi Su, Eun La Kim, Jongki Hong, Hae Young Chung, Hyung Sik Kim, Jun Yin, Jee H. Jung
Publikováno v:
Marine Drugs, Vol 12, Iss 2, Pp 926-939 (2014)
A series of N-substituted phthalimide derivatives were synthesized based on a pharmacophore study of paecilocin A (a natural PPAR-γ agonist) and synthetic leads. The introduction of hydrophilic and hydrophobic groups to the phthalimide skeleton yiel
Externí odkaz:
https://doaj.org/article/79714100cf624a04914f82ece191b0ed
Autor:
Zhiran Ju, Mingzhi Su, Dandan Li, Jongki Hong, Dong-Soon Im, Suhkmann Kim, Eun La Kim, Jee H. Jung
Publikováno v:
Marine Drugs, Vol 17, Iss 6, p 321 (2019)
In our previous study, a synthetic compound, (+)-(R,E)-6a1, that incorporated the key structures of anti-inflammatory algal metabolites and the endogenous peroxisome proliferator-activated receptor γ (PPAR-γ) ligand 15-deoxy-∆12,14-prostaglandin
Externí odkaz:
https://doaj.org/article/91a2a7d97cff48d1b88cf3dcc03139c5
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 1, p 802 (2023)
Atractylodin is a major compound in the rhizome of Atractylodes lancea, an oriental herbal medicine used for the treatment of gastrointestinal diseases, including dyspepsia, nausea, and diarrhea. Recent studies have shown that atractylodin exerts ant
Externí odkaz:
https://doaj.org/article/1a672aa4d02b48b2b8534bfebed5b68d