Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Eric L. Nuermberger"'
Autor:
Simon R. Green, Susan H. Davis, Sebastian Damerow, Curtis A. Engelhart, Michael Mathieson, Beatriz Baragaña, David A. Robinson, Jevgenia Tamjar, Alice Dawson, Fabio K. Tamaki, Kirsteen I. Buchanan, John Post, Karen Dowers, Sharon M. Shepherd, Chimed Jansen, Fabio Zuccotto, Ian H. Gilbert, Ola Epemolu, Jennifer Riley, Laste Stojanovski, Maria Osuna-Cabello, Esther Pérez-Herrán, María José Rebollo, Laura Guijarro López, Patricia Casado Castro, Isabel Camino, Heather C. Kim, James M. Bean, Navid Nahiyaan, Kyu Y. Rhee, Qinglan Wang, Vee Y. Tan, Helena I. M. Boshoff, Paul J. Converse, Si-Yang Li, Yong S. Chang, Nader Fotouhi, Anna M. Upton, Eric L. Nuermberger, Dirk Schnappinger, Kevin D. Read, Lourdes Encinas, Robert H. Bates, Paul G. Wyatt, Laura A. T. Cleghorn
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Tuberculosis is a major cause of mortality, and the rise of drug-resistant strains of Mycobacterium tuberculosis requires the urgent development of safe and effective treatments. In this work, the authors develop a compound against lysyl-tRNA synthet
Externí odkaz:
https://doaj.org/article/3aefb9dc25794e5b8cda7dfd998654ed
Autor:
Oren Gordon, Dustin A. Dikeman, Roger V. Ortines, Yu Wang, Christine Youn, Mohammed Mumtaz, Nicholas Orlando, Jeffrey Zhang, Aman M. Patel, Ethan Gough, Amit Kaushik, Eric L. Nuermberger, Anna M. Upton, Nader Fotouhi, Lloyd S. Miller, Nathan K. Archer
Publikováno v:
Microbiology Spectrum, Vol 10, Iss 5 (2022)
ABSTRACT Staphylococcus aureus is an important cause of various infections in humans, including bacteremia, skin and soft tissue infections, and infections associated with implanted medical devices. The emergence of hospital- and community-acquired m
Externí odkaz:
https://doaj.org/article/d6e58e0732d248c5ad23795e60ded5ae
Autor:
Hunter R. Batchelder, Elizabeth Story-Roller, Evan P. Lloyd, Amit Kaushik, Kristina M. Bigelow, Emily C. Maggioncalda, Eric L. Nuermberger, Gyanu Lamichhane, Craig A. Townsend
Publikováno v:
Communications Biology, Vol 3, Iss 1, Pp 1-5 (2020)
Batchelder et al. report a new penem class antibiotic, T405, which exhibits potent activity against M. abscessus and clinical isolates from cystic fibrosis patients. The development of resistance to T405 is inhibited with the addition of a β-lactama
Externí odkaz:
https://doaj.org/article/5e507dd0a49447c7b96b6dc7becd6906
Publikováno v:
mBio, Vol 12, Iss 3 (2021)
Limited knowledge regarding Mycobacterium abscessusM. abscessusin vitroM. tuberculosisM. aviumhominissuis
Externí odkaz:
https://doaj.org/article/eb29d45b4c9743d2a54c93d681b2ba34
Autor:
Alvaro A. Ordonez, Rokeya Tasneen, Supriya Pokkali, Ziyue Xu, Paul J. Converse, Mariah H. Klunk, Daniel J. Mollura, Eric L. Nuermberger, Sanjay K. Jain
Publikováno v:
Disease Models & Mechanisms, Vol 9, Iss 7, Pp 779-788 (2016)
Cavitation is a key pathological feature of human tuberculosis (TB), and is a well-recognized risk factor for transmission of infection, relapse after treatment and the emergence of drug resistance. Despite intense interest in the mechanisms underlyi
Externí odkaz:
https://doaj.org/article/72ddff99f24e486ead43518f22540e68
Autor:
Scott M. Irwin, Emily Driver, Edward Lyon, Christopher Schrupp, Gavin Ryan, Mercedes Gonzalez-Juarrero, Randall J. Basaraba, Eric L. Nuermberger, Anne J. Lenaerts
Publikováno v:
Disease Models & Mechanisms, Vol 8, Iss 6, Pp 591-602 (2015)
Cost-effective animal models that accurately reflect the pathological progression of pulmonary tuberculosis are needed to screen and evaluate novel tuberculosis drugs and drug regimens. Pulmonary disease in humans is characterized by a number of hete
Externí odkaz:
https://doaj.org/article/5815a8cf872d4063b70f53f197d677e8
Publikováno v:
Disease Models & Mechanisms, Vol 8, Iss 6, Pp 603-610 (2015)
Mice are the most commonly used species for non-clinical evaluations of drug efficacy against tuberculosis (TB). Unlike commonly used strains, C3HeB/FeJ mice develop caseous necrosis in the lung, which might alter the representation of drug efficacy
Externí odkaz:
https://doaj.org/article/289326d1a3a144e29943546126f41a89
Autor:
Jessica Z. Kubicek-Sutherland, Dung M. Vu, Aaron S. Anderson, Timothy C. Sanchez, Paul J. Converse, Ricardo Martí-Arbona, Eric L. Nuermberger, Basil I. Swanson, Harshini Mukundan
Publikováno v:
Toxins, Vol 11, Iss 4, p 202 (2019)
Mycolactone, the amphiphilic macrolide toxin secreted by Mycobacterium ulcerans, plays a significant role in the pathology and manifestations of Buruli ulcer (BU). Consequently, it follows that the toxin is a suitable target for the development of di
Externí odkaz:
https://doaj.org/article/005707b03a6c4fb8825d5999de8ef8ac
Autor:
Ravindra Jadhav, Ricardo Gallardo-Macias, Gaurav Kumar, Samer S Daher, Amit Kaushik, Kristina M Bigelow, Eric L Nuermberger, Gyanu Lamichhane, Joel S Freundlich
Publikováno v:
PLoS ONE, Vol 16, Iss 5, p e0249841 (2021)
We present further study of a subset of carbapenems, arising from a previously reported machine learning approach, with regard to their mouse pharmacokinetic profiling and subsequent study in a mouse model of sub-acute Mycobacterium tuberculosis infe
Externí odkaz:
https://doaj.org/article/69535c1c1e5b45e6b864c3a87b820f15
Autor:
Brendon M Lee, Liam K Harold, Deepak V Almeida, Livnat Afriat-Jurnou, Htin Lin Aung, Brian M Forde, Kiel Hards, Sacha J Pidot, F Hafna Ahmed, A Elaaf Mohamed, Matthew C Taylor, Nicholas P West, Timothy P Stinear, Chris Greening, Scott A Beatson, Eric L Nuermberger, Gregory M Cook, Colin J Jackson
Publikováno v:
PLoS Pathogens, Vol 16, Iss 2, p e1008287 (2020)
Our inability to predict which mutations could result in antibiotic resistance has made it difficult to rapidly identify the emergence of resistance, identify pre-existing resistant populations, and manage our use of antibiotics to effectively treat
Externí odkaz:
https://doaj.org/article/629ad11999c74ffea6fbd52642dcfe21