Zobrazeno 1 - 10
of 43
pro vyhledávání: '"David Karasik"'
Autor:
Geng Tian, David Karasik, Jianguo Tao, Wen Jin, Haisheng Zhang, Pianpian Zhao, Zhimin Ying, Chengda Yuan, Ao Dong, Xiangjiao Yi, Mengyuan Yang, Weiliang Tian, Houfeng Zheng
Publikováno v:
General Psychiatry, Vol 37, Iss 3 (2024)
Background There is limited evidence suggesting that osteoporosis might exacerbate depressive symptoms, while more studies demonstrate that depression negatively affects bone density and increases fracture risk.Aims To explore the relationship betwee
Externí odkaz:
https://doaj.org/article/3d04676d6699440aa495d84fc9c04360
Autor:
Rita De Gasperi, Laszlo Csernoch, Beatrix Dienes, Monika Gonczi, Jayanta K Chakrabarty, Shahar Goeta, Abdurrahman Aslan, Carlos A Toro, David Karasik, Lewis M Brown, Marco Brotto, Christopher P Cardozo
Publikováno v:
eLife, Vol 12 (2024)
Here, we investigated the mechanisms by which aging-related reductions of the levels of Numb in skeletal muscle fibers contribute to loss of muscle strength and power, two critical features of sarcopenia. Numb is an adaptor protein best known for its
Externí odkaz:
https://doaj.org/article/0f068916cd8b4549bdd0767378793140
Autor:
Pianpian Zhao, Zhifeng Sheng, Lin Xu, Peng Li, Wenjin Xiao, Chengda Yuan, Zhanwei Xu, Mengyuan Yang, Yu Qian, Jiadong Zhong, Jiaxuan Gu, David Karasik, Hou-Feng Zheng
Publikováno v:
eLife, Vol 12 (2024)
The ‘diabetic bone paradox’ suggested that type 2 diabetes (T2D) patients would have higher areal bone mineral density (BMD) but higher fracture risk than individuals without T2D. In this study, we found that the genetically predicted T2D was ass
Externí odkaz:
https://doaj.org/article/e05426f7f8f84f158e7c15a544372d27
Autor:
Paola Nicoletti, Samreen Zafer, Lital Matok, Inbar Irron, Meidva Patrick, Rotem Haklai, John Erol Evangelista, Giacomo B. Marino, Avi Ma’ayan, Anshuman Sewda, Greg Holmes, Sierra R. Britton, Won Jun Lee, Meng Wu, Ying Ru, Eric Arnaud, Lorenzo Botto, Lawrence C. Brody, Jo C. Byren, Michele Caggana, Suzan L. Carmichael, Deirdre Cilliers, Kristin Conway, Karen Crawford, Araceli Cuellar, Federico Di Rocco, Michael Engel, Jeffrey Fearon, Marcia L. Feldkamp, Richard Finnell, Sarah Fisher, Christian Freudlsperger, Gemma Garcia-Fructuoso, Rhinda Hagge, Yann Heuzé, Raymond J. Harshbarger, Charlotte Hobbs, Meredith Howley, Mary M. Jenkins, David Johnson, Cristina M. Justice, Alex Kane, Denise Kay, Arun Kumar Gosain, Peter Langlois, Laurence Legal-Mallet, Angela E. Lin, James L. Mills, Jenny E.V. Morton, Peter Noons, Andrew Olshan, John Persing, Julie M. Phipps, Richard Redett, Jennita Reefhuis, Elias Rizk, Thomas D. Samson, Gary M. Shaw, Robert Sicko, Nataliya Smith, David Staffenberg, Joan Stoler, Elizabeth Sweeney, Peter J. Taub, Andrew T. Timberlake, Jolanta Topczewska, Steven A. Wall, Alexander F. Wilson, Louise C. Wilson, Simeon A. Boyadjiev, Andrew O.M. Wilkie, Joan T. Richtsmeier, Ethylin Wang Jabs, Paul A. Romitti, David Karasik, Ramon Y. Birnbaum, Inga Peter
Publikováno v:
Genetics in Medicine Open, Vol 2, Iss , Pp 101851- (2024)
Purpose: The etiopathogenesis of coronal nonsyndromic craniosynostosis (cNCS), a congenital condition defined by premature fusion of 1 or both coronal sutures, remains largely unknown. Methods: We conducted the largest genome-wide association study o
Externí odkaz:
https://doaj.org/article/7b6e059bb8a041158140daf3599c8d99
Autor:
Carolina Medina-Gomez, Benjamin H. Mullin, Alessandra Chesi, Vid Prijatelj, John P. Kemp, Chen Shochat-Carvalho, Katerina Trajanoska, Carol Wang, Raimo Joro, Tavia E. Evans, Katharina E. Schraut, Ruifang Li-Gao, Tarunveer S. Ahluwalia, M. Carola Zillikens, Kun Zhu, Dennis O. Mook-Kanamori, Daniel S. Evans, Maria Nethander, Maria J. Knol, Gudmar Thorleifsson, Ivana Prokic, Babette Zemel, Linda Broer, Fiona E. McGuigan, Natasja M. van Schoor, Sjur Reppe, Mikolaj A. Pawlak, Stuart H. Ralston, Nathalie van der Velde, Mattias Lorentzon, Kari Stefansson, Hieab H. H. Adams, Scott G. Wilson, M. Arfan Ikram, John P. Walsh, Timo A. Lakka, Kaare M. Gautvik, James F. Wilson, Eric S. Orwoll, Cornelia M. van Duijn, Klaus Bønnelykke, Andre G. Uitterlinden, Unnur Styrkársdóttir, Kristina E. Akesson, Timothy D. Spector, Jonathan H. Tobias, Claes Ohlsson, Janine F. Felix, Hans Bisgaard, Struan F. A. Grant, J. Brent Richards, David M. Evans, Bram van der Eerden, Jeroen van de Peppel, Cheryl Ackert-Bicknell, David Karasik, Erika Kague, Fernando Rivadeneira
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-12 (2023)
Abstract Skull bone mineral density (SK-BMD) provides a suitable trait for the discovery of key genes in bone biology, particularly to intramembranous ossification, not captured at other skeletal sites. We perform a genome-wide association meta-analy
Externí odkaz:
https://doaj.org/article/48a29b7a20594248bc9b5e7eb32dd872
Autor:
Qihua Tan, Anaïs Marie Julie Møller, Chuan Qiu, Jonna Skov Madsen, Hui Shen, Troels Bechmann, Jean-Marie Delaisse, Bjarne Winther Kristensen, Hong-Wen Deng, David Karasik, Kent Søe
Publikováno v:
Clinical Epigenetics, Vol 15, Iss 1, Pp 1-14 (2023)
Abstract Background Clinical trials have shown zoledronic acid as a potent bisphosphonate in preventing bone loss, but with varying potency between patients. Human osteoclasts ex vivo reportedly displayed a variable sensitivity to zoledronic acid > 2
Externí odkaz:
https://doaj.org/article/9718cb5c044c48b18465cf4ae6ccc452
Autor:
Jiang-Wei Xia, Lin Zhang, Jin Li, Cheng-Da Yuan, Xiao-Wei Zhu, Yu Qian, Saber Khederzadeh, Jia-Xuan Gu, Lin Xu, Jian-Hua Gao, Ke-Qi Liu, David Karasik, Shu-Yang Xie, Guo-Bo Chen, Hou-Feng Zheng
Publikováno v:
BMC Medicine, Vol 20, Iss 1, Pp 1-13 (2022)
Abstract Background Birth weight is considered not only to undermine future growth, but also to induce lifelong diseases; the aim of this study is to explore the relationship between birth weight and adult bone mass. Methods We performed multivariabl
Externí odkaz:
https://doaj.org/article/fbe50807f3314eedb242b875a6bc5863
Autor:
Claire J Watson, W Joyce Tang, Maria F Rojas, Imke A K Fiedler, Ernesto Morfin Montes de Oca, Andrea R Cronrath, Lulu K Callies, Avery Angell Swearer, Ali R Ahmed, Visali Sethuraman, Sumaya Addish, Gist H Farr, Arianna Ericka Gómez, Jyoti Rai, Adrian T Monstad-Rios, Edith M Gardiner, David Karasik, Lisa Maves, Bjorn Busse, Yi-Hsiang Hsu, Ronald Young Kwon
Publikováno v:
PLoS Genetics, Vol 18, Iss 11, p e1010496 (2022)
Bone and muscle are coupled through developmental, mechanical, paracrine, and autocrine signals. Genetic variants at the CPED1-WNT16 locus are dually associated with bone- and muscle-related traits. While Wnt16 is necessary for bone mass and strength
Externí odkaz:
https://doaj.org/article/5c1e0f2009e24bea8e2128b9e43705bc
Autor:
Iryna Khrystoforova, Chen Shochat-Carvalho, Ram Harari, Katrin Henke, Katherine Woronowicz, Matthew P. Harris, David Karasik
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
Low-density Lipoprotein Receptor-related Protein 5 (LRP5) functions as a co-receptor for Wnt ligands, controlling expression of genes involved in osteogenesis. In humans, loss-of-function mutations in LRP5 cause Osteoporosis-Pseudoglioma syndrome, a
Externí odkaz:
https://doaj.org/article/7fa248de1de64602bd35433008dbf52e
Autor:
Xiao-Wei Zhu, Ke-Qi Liu, Cheng-Da Yuan, Jiang-Wei Xia, Yu Qian, Lin Xu, Jian-Hua Gao, Xiao-Li Rong, Guo-Bo Chen, David Karasik, Shu-Yang Xie, Hou-Feng Zheng
Publikováno v:
iScience, Vol 25, Iss 6, Pp 104466- (2022)
Summary: To infer the causality between obesity and fracture and the difference between general and abdominal obesity, a prospective study was performed in 456,921 participants, and 10,142 participants developed an incident fracture with follow-up pe
Externí odkaz:
https://doaj.org/article/9423150cc6654184a04a048aec826749