Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Charles R. Mackay"'
Autor:
Kirstine J. Bell, Sonia Saad, Bree J. Tillett, Helen M. McGuire, Sara Bordbar, Yu Anne Yap, Long T. Nguyen, Marc R. Wilkins, Susan Corley, Shannon Brodie, Sussan Duong, Courtney J. Wright, Stephen Twigg, Barbara Fazekas de St Groth, Leonard C. Harrison, Charles R. Mackay, Esteban N. Gurzov, Emma E. Hamilton-Williams, Eliana Mariño
Publikováno v:
Microbiome, Vol 10, Iss 1, Pp 1-21 (2022)
Abstract Background Short-chain fatty acids (SCFAs) produced by the gut microbiota have beneficial anti-inflammatory and gut homeostasis effects and prevent type 1 diabetes (T1D) in mice. Reduced SCFA production indicates a loss of beneficial bacteri
Externí odkaz:
https://doaj.org/article/e25eb74805594ff78c91c45cb9747d55
Autor:
Peter J. Vuillermin, Martin O’Hely, Fiona Collier, Katrina J. Allen, Mimi L. K. Tang, Leonard C. Harrison, John B. Carlin, Richard Saffery, Sarath Ranganathan, Peter D. Sly, Lawrence Gray, John Molloy, Angela Pezic, Michael Conlon, David Topping, Karen Nelson, Charles R. Mackay, Laurence Macia, Jennifer Koplin, Samantha L. Dawson, Margarita Moreno-Betancur, Anne-Louise Ponsonby, the J. Craig Venter Institute, the BIS Investigator Group
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-7 (2020)
Incidence of food allergy in westernized populations is associated with low abundance of Prevotella. Here, the authors analyse the microbiome of a mother-infant prebirth cohort and find that maternal carriage, but not infant carriage, of P. copri dur
Externí odkaz:
https://doaj.org/article/48c619686c2c46b9920e7b85a53be041
Autor:
Yunzi Liu, Yan J. Li, Yik W. Loh, Julian Singer, Weiping Zhu, Laurence Macia, Charles R. Mackay, Weiming Wang, Steven J. Chadban, Huiling Wu
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Short-chain fatty acids (SCFA) derived from gut microbial fermentation of fiber have been shown to exert anti-inflammatory and immune-modulatory properties in acute kidney injury (AKI). However the direct mechanistic link between SCFAs, diet and the
Externí odkaz:
https://doaj.org/article/05b6ea015ccb4f32bd9a7cab97c8e814
Autor:
Mingjing Hu, David Eviston, Peter Hsu, Eliana Mariño, Ann Chidgey, Brigitte Santner-Nanan, Kahlia Wong, James L. Richards, Yu Anne Yap, Fiona Collier, Ann Quinton, Steven Joung, Michael Peek, Ron Benzie, Laurence Macia, David Wilson, Ann-Louise Ponsonby, Mimi L. K. Tang, Martin O’Hely, Norelle L. Daly, Charles R. Mackay, Jane E. Dahlstrom, The BIS Investigator Group, Peter Vuillermin, Ralph Nanan
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Maternal immunological dysregulation might affect the immunological development of the fetus. Here the authors show that decreased maternal acetate is associated with preeclampsia, impaired fetal thymic output and regulatory T cell development.
Externí odkaz:
https://doaj.org/article/c9a435d8124048e595fe54577e177533
Autor:
Krist Helen Antunes, José Luís Fachi, Rosemeire de Paula, Emanuelle Fraga da Silva, Laís Passariello Pral, Adara Áurea dos Santos, Greicy Brisa Malaquias Dias, José Eduardo Vargas, Renato Puga, Fabiana Quoos Mayer, Fábio Maito, Carlos R. Zárate-Bladés, Nadim J. Ajami, Marcella Ramos Sant’Ana, Thamiris Candreva, Hosana Gomes Rodrigues, Marcio Schmiele, Maria Teresa Pedrosa Silva Clerici, José Luiz Proença-Modena, Angélica Thomas Vieira, Charles R. Mackay, Daniel Mansur, Mauricio T. Caballero, Jacqui Marzec, Jianying Li, Xuting Wang, Douglas Bell, Fernando P. Polack, Steven R. Kleeberger, Renato T. Stein, Marco Aurélio Ramirez Vinolo, Ana Paula Duarte de Souza
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
Dietary fibers and SCFAs can exert a protective effect against respiratory syncytial virus (RSV). Here, the authors report that microbiota-derived acetate protects mice against RSV infection via GPR43- mediated type 1 interferon response induction in
Externí odkaz:
https://doaj.org/article/c60e76919412482d9d4459cf276f5674
Autor:
Md Jahangir Alam, Liang Xie, Caroline Ang, Farnaz Fahimi, Stephen B. Willingham, Andrew J. Kueh, Marco J. Herold, Charles R. Mackay, Remy Robert
Publikováno v:
mAbs, Vol 12, Iss 1 (2020)
Neutrophils are the most abundant effector cells of the innate immune system and represent the first line of defense against infection. However, in many common pathologies, including autoimmune diseases, excessive recruitment and activation of neutro
Externí odkaz:
https://doaj.org/article/548ebefe31094398bc74f2e24eff5483
Autor:
Dana Piovesan, Jessica Tempany, Andrea Di Pietro, Inge Baas, Callisthenis Yiannis, Kristy O’Donnell, Yunshun Chen, Victor Peperzak, Gabrielle T. Belz, Charles R. Mackay, Gordon K. Smyth, Joanna R. Groom, David M. Tarlinton, Kim L. Good-Jacobson
Publikováno v:
Cell Reports, Vol 19, Iss 3, Pp 461-470 (2017)
Summary: Humoral immune responses are tailored to the invading pathogen through regulation of key transcription factors and their networks. This is critical to establishing effective antibody-mediated responses, yet it is unknown how B cells integrat
Externí odkaz:
https://doaj.org/article/3c81bb09b0d54bd388012d93887c7861
Autor:
Lucy Brooks, Alexander Viardot, Anastasia Tsakmaki, Emilie Stolarczyk, Jane K. Howard, Patrice D. Cani, Amandine Everard, Michelle L. Sleeth, Arianna Psichas, Jelena Anastasovskaj, Jimmy D. Bell, Kim Bell-Anderson, Charles R. Mackay, Mohammad A. Ghatei, Stephen R. Bloom, Gary Frost, Gavin A. Bewick
Publikováno v:
Molecular Metabolism, Vol 6, Iss 1, Pp 48-60 (2017)
Objective: Dietary supplementation with fermentable carbohydrate protects against body weight gain. Fermentation by the resident gut microbiota produces short-chain fatty acids, which act at free fatty acid receptor 2 (FFAR2). Our aim was to test the
Externí odkaz:
https://doaj.org/article/6e138d5bb03648ce81d279034f1eb881
Autor:
Jian Tan, Craig McKenzie, Peter J. Vuillermin, Gera Goverse, Carola G. Vinuesa, Reina E. Mebius, Laurence Macia, Charles R. Mackay
Publikováno v:
Cell Reports, Vol 15, Iss 12, Pp 2809-2824 (2016)
The incidence of food allergies in western countries has increased dramatically in recent decades. Tolerance to food antigens relies on mucosal CD103+ dendritic cells (DCs), which promote differentiation of regulatory T (Treg) cells. We show that hig
Externí odkaz:
https://doaj.org/article/007fe71e36a64e44a8b4820eb54f9198
Autor:
Izabela Galvão, Luciana P. Tavares, Renan O. Corrêa, José Luís Fachi, Vitor Melo Rocha, Marcela Rungue, Cristiana C. Garcia, Geovanni Cassali, Caroline M. Ferreira, Flaviano S. Martins, Sergio C. Oliveira, Charles R. Mackay, Mauro M. Teixeira, Marco Aurélio R. Vinolo, Angélica T. Vieira
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Pneumonia is one of the leading causes of death and mortality worldwide. The inflammatory responses that follow respiratory infections are protective leading to pathogen clearance but can also be deleterious if unregulated. The microbiota is known to
Externí odkaz:
https://doaj.org/article/7b2138200346497aa71a40ee3bc3f7f0