Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Adam Langenbucher"'
Autor:
Alex B. Miller, Felicia H. Rodriguez, Adam Langenbucher, Lin Lin, Christina Bray, Sarah Duquette, Ye Zhang, Dan Goulet, Andrew A. Lane, David M. Weinstock, Michael T. Hemann, Scott R. Manalis
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-10 (2024)
Abstract Leukemias and their bone marrow microenvironments undergo dynamic changes over the course of disease. However, little is known about the circulation kinetics of leukemia cells, nor the impact of specific factors on the clearance of circulati
Externí odkaz:
https://doaj.org/article/d7dcccfc6e274a74a593913922844621
Autor:
Lydie Debaize, Ye Zhang, Michelle Ramseier, Mingzeng Zhang, Adam Langenbucher, Peter S. Winter, Ran Xu, Nezha Senhaji, Robert A Redd, Martin J. Aryee, Paul H. Branch, Austin I. Kim, David M. Weinstock, Alex Shalek, Scott R. Manalis, Mark A. Murakami
Publikováno v:
HemaSphere, Vol 7, p e96705d3 (2023)
Externí odkaz:
https://doaj.org/article/713cb23b4f6148cd99681bf90cefde7a
Autor:
Nana Chen, Gabriel Golczer, Subhoshree Ghose, Brian Lin, Adam Langenbucher, Jason Webb, Haymanti Bhanot, Nicholas B. Abt, Derrick Lin, Mark Varvares, Martin Sattler, Ann Marie Egloff, Richard Joh, Ravindra Uppaluri, Kevin S. Emerick, Michael S. Lawrence, Srinivas Vinod Saladi
Publikováno v:
Cell Reports, Vol 39, Iss 11, Pp 110970- (2022)
Summary: Analysis of The Cancer Genome Atlas and other published data of head and neck squamous cell carcinoma (HNSCC) reveals somatic alterations of the Hippo-YAP pathway in approximately 50% of HNSCC. Better strategies to target the YAP1 transcript
Externí odkaz:
https://doaj.org/article/13be6881b6a64f958b845f078f8a66c3
Autor:
Adam Langenbucher, Danae Bowen, Ramin Sakhtemani, Elodie Bournique, Jillian F. Wise, Lee Zou, Ashok S. Bhagwat, Rémi Buisson, Michael S. Lawrence
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
The APOBEC mutation signature contributes to a significant percentage of human cancers. Here the authors via biochemical and computational analyses shed light on how DNA primary sequence and secondary structure jointly influence A3A substrate optimal
Externí odkaz:
https://doaj.org/article/0df7d51a696e4dfaa11c6266dbb37d50
Autor:
Pégah Jalili, Danae Bowen, Adam Langenbucher, Shinho Park, Kevin Aguirre, Ryan B. Corcoran, Angela G. Fleischman, Michael S. Lawrence, Lee Zou, Rémi Buisson
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
The DNA cytosine deaminases APOBEC3A and APOBEC3B have emerged from cancer genomics studies as drivers of mutation in cancers and tumor heterogeneity. Here the authors present a computational approach to identify the RNA mutations specifically driven
Externí odkaz:
https://doaj.org/article/ce56509c93e8439dabb97f9c99412c8c
Autor:
Sooncheol Lee, Douglas Micalizzi, Samuel S. Truesdell, Syed I. A. Bukhari, Myriam Boukhali, Jennifer Lombardi-Story, Yasutaka Kato, Min-Kyung Choo, Ipsita Dey-Guha, Fei Ji, Benjamin T. Nicholson, David T. Myers, Dongjun Lee, Maria A. Mazzola, Radhika Raheja, Adam Langenbucher, Nicholas J. Haradhvala, Michael S. Lawrence, Roopali Gandhi, Christopher Tiedje, Manuel D. Diaz-Muñoz, David A. Sweetser, Ruslan Sadreyev, David Sykes, Wilhelm Haas, Daniel A. Haber, Shyamala Maheswaran, Shobha Vasudevan
Publikováno v:
Genome Biology, Vol 21, Iss 1, Pp 1-23 (2020)
Abstract Background Quiescence (G0) is a transient, cell cycle-arrested state. By entering G0, cancer cells survive unfavorable conditions such as chemotherapy and cause relapse. While G0 cells have been studied at the transcriptome level, how post-t
Externí odkaz:
https://doaj.org/article/3a979733efdc48f9906f993aa9cadbcb
Autor:
Daniel L. Faden, Krystle A. Lang Kuhs, Maoxuan Lin, Adam Langenbucher, Maisa Pinheiro, Meredith Yeager, Michael Cullen, Joseph F. Boland, Mia Steinberg, Sara Bass, James S. Lewis, Michael S. Lawrence, Robert L. Ferris, Lisa Mirabello
Publikováno v:
Viruses, Vol 13, Iss 8, p 1666 (2021)
APOBEC is a mutagenic source in human papillomavirus (HPV)-mediated malignancies, including HPV+ oropharyngeal squamous cell carcinoma (HPV + OPSCC), and in HPV genomes. It is unknown why APOBEC mutations predominate in HPV + OPSCC, or if the APOBEC-
Externí odkaz:
https://doaj.org/article/4876a4f80f6449fcaf4f7085f50b8efc