Zobrazeno 1 - 10
of 103
pro vyhledávání: ''
Publikováno v:
Journal of periodontal research. 56(5):972-981
Background/objectives Cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) is a critical immunoregulatory molecule expressed on T cells. CTLA-4 also binds to the surfaces of monocytes and macrophages, precursors of osteoclasts. Research on rheumatoid
Autor:
Josef Zamecnik, Anatoly Korotkov, Martha Feucht, Mark J. Luinenburg, Wim Van Hecke, Jeong H Lee, Caroline Mijnsbergen, Lieven Lagae, Till S. Zimmer, Wim G.M. Spliet, Floor E. Jansen, Katarzyna Kotulska, Jackelien van Scheppingen, Paolo Curatolo, Jasper J. Anink, Nam Suk Sim, Angelika Mühlebner, Pavel Krsek, Johannes A. Hainfellner, Sergiusz Jozwiak, Peter C. van Rijen, Erwin A. van Vliet, Diede W. M. Broekaart, David J. Kwiatkowski, Peter B. Crino, Anna Jansen, Eleonora Aronica, Anika Bongaarts, James D. Mills
Publikováno v:
Neuropathology and Applied Neurobiology
Neuropathology and Applied Neurobiology, 47, 796-811. Wiley-Blackwell
Neuropathology and Applied Neurobiology, 47(6), 796-811. Wiley-Blackwell
Neuropathology and applied neurobiology, 47(6), 796-811. Wiley-Blackwell
Neuropathology and Applied Neurobiology, 47, 796-811. Wiley-Blackwell
Neuropathology and Applied Neurobiology, 47(6), 796-811. Wiley-Blackwell
Neuropathology and applied neurobiology, 47(6), 796-811. Wiley-Blackwell
Aims Tuberous sclerosis complex (TSC) is a genetic disorder associated with dysregulation of the mechanistic target of rapamycin complex 1 (mTORC1) signalling pathway. Neurodevelopmental disorders, frequently present in TSC, are linked to cortical tu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1eb0f7241374fa2ea6880a3964dbd171
https://dare.uva.nl/personal/pure/en/publications/microrna34a-activation-in-tuberous-sclerosis-complex-during-early-brain-development-may-lead-to-impaired-corticogenesis(54e41bc9-19fa-4850-90b0-8be834807835).html
https://dare.uva.nl/personal/pure/en/publications/microrna34a-activation-in-tuberous-sclerosis-complex-during-early-brain-development-may-lead-to-impaired-corticogenesis(54e41bc9-19fa-4850-90b0-8be834807835).html
Autor:
Marion Kever, Evelien Jongepier, Marah Stoldt, Romain Libbrecht, Inon Scharf, Susanne Foitzik, Anna Lena Höpfner
Publikováno v:
Molecular Ecology, 30(10), 2378-2389. Wiley-Blackwell
Humans and other social mammals experience isolation from their group as stressful, triggering behavioural and physiological anomalies that reduce fitness. While social isolation has been intensely studied in social mammals, it is less clear how soci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::923c7160a8e06369264ad74c9b83d695
https://dare.uva.nl/personal/pure/en/publications/social-isolation-causes-downregulation-of-immune-and-stress-response-genes-and-behavioural-changes-in-a-social-insect(7a3d3936-55c3-465c-8514-c18c79378a9c).html
https://dare.uva.nl/personal/pure/en/publications/social-isolation-causes-downregulation-of-immune-and-stress-response-genes-and-behavioural-changes-in-a-social-insect(7a3d3936-55c3-465c-8514-c18c79378a9c).html
Autor:
Hiroyuki Katsuragawa, Yosuke Yamada, Tatsuki R. Kataoka, Masakazu Fujimoto, Yo Kaku, Yoshihiro Ishida, Hironori Haga
Publikováno v:
Pathology International. 70(11):881-887
Langerhans cell sarcoma (LCS) is a high-grade neoplasm with overtly malignant cytological features and a Langerhans cell phenotype. The underlying genetic features are poorly understood, and only a few alterations, such as those of the MARK pathway-r
Autor:
Cai, Yang, Folkerts, Jelle, Folkerts, Gert, Maurer, Marcus, Braber, Saskia, Afd Pharmacology, Pharmacology
Publikováno v:
British Journal of Pharmacology, 177(6), 1363. Wiley-Blackwell
Br J Pharmacol
British Journal of Pharmacology, 177, 1363-1381. Wiley-Blackwell
Br J Pharmacol
British Journal of Pharmacology, 177, 1363-1381. Wiley-Blackwell
Dietary fibre, such as indigestible oligosaccharides and polysaccharides, occurs in many foods and has gained considerable importance related to its beneficial effects on host health and specific diseases. Dietary fibre is neither digested nor absorb
Autor:
Tjakko J. van Ham, Laia Montoliu-Gaya, Niklas Darin, Fredrik H. Sterky, Leslie E. Sanderson, Lars Schlotawa, Kalliopi Sofou, Maria Blomqvist, Jutta Gärtner, Emma Samuelsson, Jorge Asin Cayuela, Chris Mühlhausen, Kolja Meier, Tahsin Stefan Barakat, Debora Kaminski, Lotta Agholme
Publikováno v:
EMBO Molecular Medicine, Vol 13, Iss 5, Pp n/a-n/a (2021)
EMBO Molecular Medicine
EMBO Molecular Medicine, 13(5):e13376. Wiley-Blackwell
EMBO Molecular Medicine
EMBO Molecular Medicine, 13(5):e13376. Wiley-Blackwell
Lysosomal storage diseases, including mucopolysaccharidoses, result from genetic defects that impair lysosomal catabolism. Here, we describe two patients from two independent families presenting with progressive psychomotor regression, delayed myelin
Autor:
Andrew T. Chan, David Conen, Caroline Pot, Therese Lincke, Stephanie Meier, Chiara Zecca, Muhamed Barakovic, David Leppert, Johanna Oechtering, Sabine Schaedelin, Özgür Yaldizli, Oliver Findling, Jens Kuhle, Yvonne Naegelin, Stefanie Aeschbacher, Tobias Derfuss, Bettina Fischer-Barnicol, Aleksandra Maceski, Ingmar Heijnen, Tim Sinnecker, Patrice H. Lalive, Suvitha Subramaniam, Pascal Benkert, Heinz Wiendl, Riccardo Galbusera, Reza Rahmanzadeh, Giulio Disanto, Claudio Gobbi, Axel Regeniter, Lutz Achtnichts, J.M. Lieb, Ludwig Kappos, Klaus Berger, Annette Orleth, Jens Wuerfel, Stefanie Müller, Jochen Vehoff, Cristina Granziera
Publikováno v:
Annals of Neurology
Oechtering, Johanna; Schaedelin, Sabine; Benkert, Pascal; Müller, Stefanie; Achtnichts, Lutz; Vehoff, Jochen; Disanto, Giulio; Findling, Oliver; Fischer-Barnicol, Bettina; Orleth, Annette; Chan, Andrew; Pot, Caroline; Barakovic, Muhamed; Rahmanzadeh, Reza; Galbusera, Riccardo; Heijnen, Ingmar; Lalive, Patrice H; Wuerfel, Jens; Subramaniam, Suvitha; Aeschbacher, Stefanie; ... (2021). Intrathecal Immunoglobulin M Synthesis is an Independent Biomarker for Higher Disease Activity and Severity in Multiple Sclerosis. Annals of neurology, 90(3), pp. 477-489. Wiley-Blackwell 10.1002/ana.26137
Annals of neurology, vol. 90, no. 3, pp. 477-489
Oechtering, Johanna; Schaedelin, Sabine; Benkert, Pascal; Müller, Stefanie; Achtnichts, Lutz; Vehoff, Jochen; Disanto, Giulio; Findling, Oliver; Fischer-Barnicol, Bettina; Orleth, Annette; Chan, Andrew; Pot, Caroline; Barakovic, Muhamed; Rahmanzadeh, Reza; Galbusera, Riccardo; Heijnen, Ingmar; Lalive, Patrice H; Wuerfel, Jens; Subramaniam, Suvitha; Aeschbacher, Stefanie; ... (2021). Intrathecal Immunoglobulin M Synthesis is an Independent Biomarker for Higher Disease Activity and Severity in Multiple Sclerosis. Annals of neurology, 90(3), pp. 477-489. Wiley-Blackwell 10.1002/ana.26137
Annals of neurology, vol. 90, no. 3, pp. 477-489
We aimed to determine in relapsing multiple sclerosis (MS) whether intrathecal synthesis of immunoglobulin (Ig) M and IgG is associated with outcomes reflecting inflammatory activity and chronic worsening. We compared cerebrospinal fluid analysis, cl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fab1fe314388de122195b79e1794d174
Autor:
Felix Bremmer, Alexander Fichtner, Nadine T. Gaisa, Stefan Küffer, Christoph Oing, Stefan Schweyer, Silke Kaulfuß, Simon Filmar, Philipp Ströbel, Daniel Nettersheim, Annika Richter, Andreas Leha, Fabian Gayer, Henning Reis
Publikováno v:
Histopathology : journal of the British Division of the International Academy of Pathology 78(4), 593-606 (2021). doi:10.1111/his.14258
Aims Malignant germ cell tumours (GCTs) of the testis are rare neoplasms, but the most common solid malignancies in young men. World Health Organization guidelines divide GCTs into five types, for which numerous immunohistochemical markers allow exac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a595897ec16b15a0e6b08531b8c4e9d
https://publications.rwth-aachen.de/record/814495
https://publications.rwth-aachen.de/record/814495
Autor:
Michael K. E. Schäfer, Yong Wang, Manuel Lang, Regina Hummel, Simona Walderbach, Christina Gölz, Irmgard Tegeder
Progranulin (PGRN) is a neurotrophic and anti-inflammatory factor with protective effects in animal models of ischemic stroke, subarachnoid hemorrhage, and traumatic brain injury (TBI). Administration of recombinant (r) PGRN prevents exaggerated brai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4dab57b19bead3a73aedb862e9c13196
Autor:
Gideon Koren, László Hiripi, P. Major, Michael Brunner, Christoph Bode, Zsuzsanna Bősze, Gerlind Franke, Stefanie Perez-Feliz, Tibor Hornyik, Katja E. Odening, István Baczkó, András Varró, Alessandro Castiglione, Manfred Zehender
Publikováno v:
Hornyik, Tibor; Castiglione, Alessandro; Franke, Gerlind; Perez-Feliz, Stefanie; Major, Péter; Hiripi, László; Koren, Gideon; Bősze, Zsuzsanna; Varró, András; Zehender, Manfred; Brunner, Michael; Bode, Christoph; Baczkó, István; Odening, Katja E. (2020). Transgenic LQT2, LQT5, and LQT2-5 rabbit models with decreased repolarisation reserve for prediction of drug-induced ventricular arrhythmias. British journal of pharmacology, 177(16), pp. 3744-3759. Wiley-Blackwell 10.1111/bph.15098
British Journal of Pharmacology
British Journal of Pharmacology
BACKGROUND AND PURPOSE Reliable prediction of pro-arrhythmic side effects of novel drug candidates is still a major challenge. Although drug-induced pro-arrhythmia occurs primarily in patients with pre-existing repolarisation disturbances, healthy an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::110c6ce9bd9a9acff489274e90e1c7a5