Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Yong J. Lee"'
Publikováno v:
Cancer Medicine, Vol 9, Iss 5, Pp 1753-1767 (2020)
Abstract Molecular‐targeted therapies have demonstrated disappointing results against most advanced solid cancers. This may largey be attributed to irrational drug use against unselected cancers. We investigated the efficacy of dual MEK‐PI3K drug
Externí odkaz:
https://doaj.org/article/12a75ad4899c4fccac51f4dc6ad15f41
Autor:
Jin Hong Kim, Abdo J. Najy, Jian Li, Xu Luo, Hyeong‐Reh C. Kim, Mohammad Haroon Asif Choudry, Yong J. Lee
Publikováno v:
Journal of Cellular Physiology. 237:4180-4196
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) induces death receptor-mediated extrinsic apoptosis, specifically in cancer cells, and Bid (BH3-interacting domain death agonist) plays an important role in TRAIL-induced apoptosis. Ferr
Autor:
Yong Seok Park, Kalishwaralal Kalimuthu, Yong J. Lee, Ja Lok Ku, Jin Hong Kim, Xu Luo, Lin Zhang, M. Haroon A. Choudry
Publikováno v:
Journal of Cellular Physiology. 236:6666-6677
Abnormalities of the tumor vasculature result in insufficient blood supply and development of a tumor microenvironment that is characterized by low glucose concentrations, low extracellular pH, and low oxygen tensions. We previously reported that glu
Autor:
Yong J. Lee, Chuanyue Wu, Se Hoon Hong, David L. Bartlett, Seog Young Kim, Yong Tae Kwon, Per H. Basse
Publikováno v:
Journal of Cellular Biochemistry. 117:2289-2301
Cancer stem cells (CSCs) are capable of initiation and metastasis of tumors. Therefore, understanding the biology of CSCs and the interaction between CSCs and their counterpart non-stem cells is crucial for developing a novel cancer therapy. We used
Autor:
Yong J. Lee, Ki Sa Sung, William T. Kwon, Zong Sheng Guo, Dae Hee Lee, David L. Bartlett, Yong Tae Kwon, Sang Cheul Oh
Publikováno v:
Journal of Cellular Biochemistry. 117:1078-1091
It is well known that tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis can be initially triggered by surface death receptors (the extrinsic pathway) and subsequently amplified through mitochondrial dysfunction (the in
Autor:
Ji H. Han, Hanho Shin, Jun G. Rho, Jung-Eun Kim, Dong H. Son, Juhwan Yoon, Yong J. Lee, Jung-Hyuck Park, Byung J. Song, Chang-Sik Choi, Seul G. Yoon, Il Y. Kim, Eun K. Lee, Je K. Seong, Ki W. Kim, Wook Kim
Publikováno v:
Diabetes, Obesity and Metabolism. 20:i-i
Publikováno v:
Journal of Cellular Biochemistry. 112:118-127
The aim of this study was to investigate the effect of garlic constituent diallyl trisulfide (DATS) on the cell-death signaling pathway in a human breast cell line (MDA-MB-231). We observed that DATS (10-100 µM) treatment resulted in dose- and time-
Autor:
Marco A. Alcala, Jinsang Yoo, David L. Bartlett, Byeong-Chel Lee, Bae-Hang Park, Dae Hee Lee, Kyung Soo Park, Yong J. Lee
Publikováno v:
Journal of Cellular Biochemistry. 110:1073-1081
Approximately 25% of patients with colorectal cancer develop metastases to the liver, and surgery is currently the best treatment available. But there are several patients who are unresectable, and isolated hepatic perfusion (IHP) offers a different
Publikováno v:
British Journal of Pharmacology. 157:1189-1202
Background and purpose: Tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) triggers apoptotic death in a variety of cancer cells without marked toxicity to most normal cells. We previously reported that wogonin, a potent anticancer agen
Publikováno v:
FEBS Journal. 276:2278-2284
Hepatic apoptosis is elevated in patients with non-alcoholic steatohepatitis and is correlated with the severity of the disease. Long-chain saturated fatty acids, such as palmitate, induce apoptosis in liver cells. The present study examined adiponec