Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Espen Molden"'
Autor:
Robert Løvsletten Smith, Birgit M. Wollmann, Elisabet Størset, Hasan Çağın Lenk, Kevin S. O'Connell, Marianne Kringen Kristiansen, Magnus Ingelman‐Sundberg, Espen Molden
Publikováno v:
Clinical and Translational Science, Vol 17, Iss 2, Pp n/a-n/a (2024)
Abstract Cytochrome P450 2D6 (CYP2D6) is important for metabolism of 20%–25% of all clinically used drugs. Many known genetic variants contribute to the large interindividual variability in CYP2D6 metabolism, but much is still unexplained. We recen
Externí odkaz:
https://doaj.org/article/bc583d3f16e243a881eff9ea3dbfb57a
Autor:
Hasan Çağın Lenk, Robert Løvsletten Smith, Kevin S. O'Connell, Marin M. Jukić, Marianne Kristiansen Kringen, Ole A. Andreassen, Magnus Ingelman‐Sundberg, Espen Molden
Publikováno v:
Clinical and Translational Science, Vol 16, Iss 1, Pp 62-72 (2023)
Abstract Clinical response of clozapine is closely associated with serum concentration. Although tobacco smoking is the key environmental factor underlying interindividual variability in clozapine metabolism, recent genome‐wide studies suggest that
Externí odkaz:
https://doaj.org/article/b404641d026a4bb681d473f000373fe3
Autor:
Line Skute Bråten, Magnus Ingelman‐Sundberg, Marin M. Jukic, Espen Molden, Marianne Kristiansen Kringen
Publikováno v:
Clinical and Translational Science, Vol 15, Iss 9, Pp 2135-2145 (2022)
Abstract Sertraline is a commonly used SSRI antidepressant drug, metabolized by CYP2C19 and CYP2B6, that exhibits a substantial interindividual variation in clinical response, of which only a part can be attributed to known genetic variants. In the c
Externí odkaz:
https://doaj.org/article/65875f5235c64f31969d93433786b3a6
Autor:
Birgit M. Wollmann, Robert L. Smith, Marianne Kristiansen Kringen, Magnus Ingelman‐Sundberg, Espen Molden, Elisabet Størset
Publikováno v:
British Journal of Clinical Pharmacology.
Publikováno v:
British Journal of Clinical Pharmacology.
Publikováno v:
Clinical pharmacology and therapeutics
The metabolic activity of the polymorphic CYP2D6 enzyme is dependent on the CYP2D6 genotype; however, the guidelines for translating the genotype into phenotype, which are of relevance for adequate drug dose personalization, are ambiguous. In the pre
Autor:
Espen Molden, Linda Thorén, Jonas Bergh, Per Hall, Sara Margolin, Erik Eliasson, Marianne Kristiansen Kringen, Jonatan D. Lindh, Gerd Ackehed
Publikováno v:
British Journal of Clinical Pharmacology. 87:1243-1252
AIMS Tamoxifen is bioactivated to endoxifen by polymorphic CYP2D6-dependent metabolism. Here, endoxifen levels were compared to CYP2D6 diplotypes, tentative target concentrations and side effects. METHODS In total, 118 Swedish premenopausal breast ca
Publikováno v:
British Journal of Clinical Pharmacology. 85:194-201
AIMS CYP2D6*9, CYP2D6*10 and CYP2D6*41 are the most frequent reduced-function CYP2D6 alleles in Caucasians. Despite lacking in vivo evidence, they are collectively classified with an enzyme activity score of 0.5. Thus, the aim of this study was to co
Autor:
Ellen Johanne Annexstad, Håvard Andreassen Sæverud, Espen Molden, Marianne Kristiansen Kringen, Yvonne Elisabeth Lao, Knut Erik Hovda, Dag Jacobsen
Publikováno v:
Basic & Clinical Pharmacology & Toxicology
Paracetamol has a good safety profile, but pharmacogenetic differences in drug-metabolizing enzymes may have an impact on its risk of hepatotoxicity. We present a case of fatal acute liver failure (ALF) after therapeutic doses of paracetamol in a pat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe642dcd88f7916223ff86f783c8cc57
https://hdl.handle.net/10642/9496
https://hdl.handle.net/10642/9496
Publikováno v:
British Journal of Clinical Pharmacology. 83:2398-2405
SummaryAim 4β-Hydroxycholesterol (4βOHC) is sensitive towards induction or inhibition of CYP3A4, but its potential usefulness as a dosing biomarker remains to be demonstrated. The aim of this study was to investigate the correlation between 4βOHC