Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Davide Trotti"'
Autor:
Brigid K. Jensen, Kevin J. McAvoy, Nicolette M. Heinsinger, Angelo C. Lepore, Hristelina Ilieva, Aaron R. Haeusler, Davide Trotti, Piera Pasinelli
Publikováno v:
Glia. 70:1426-1449
Genetic mutations that cause amyotrophic lateral sclerosis (ALS), a progressively lethal motor neuron disease, are commonly found in ubiquitously expressed genes. In addition to direct defects within motor neurons, growing evidence suggests that dysf
Autor:
Jean Philippe Richard, Kevin McAvoy, Shashirekha S. Markandaiah, Mark Sarlo, Piera Pasinelli, Hisham Qosa, Nicholas J. Maragakis, Davide Trotti, Michael R. Jablonski, Jessica Lichter
Publikováno v:
Glia. 64:1298-1313
The efficacy of drugs targeting the CNS is influenced by their limited brain access, which can lead to complete pharmacoresistance. Recently a tissue-specific and selective upregulation of the multidrug efflux transporter ABCB1 or P-glycoprotein (P-g
Autor:
Angelo C. Lepore, Davide Trotti, Victoria J. Gennaro, Michael R. Jablonski, Piera Pasinelli, Ke Li, Ni J. Meng, Shashirekha S. Markandaiah, Dena Jacob
Publikováno v:
Annals of Clinical and Translational Neurology
The limited progress in identifying successful therapies in Amyotrophic Lateral Sclerosis (ALS) has only resulted in one moderately effective pharmacological agent, riluzole.1,2 In research on the SOD1-G93A mouse model of ALS, riluzole showed a modes
Publikováno v:
Glia. 62:1241-1253
EAAT2 is a predominantly astroglial glutamate transporter responsible for the majority of synaptic glutamate clearance in the mammalian central nervous system (CNS). Its dysfunction has been linked with many neurological disorders, including amyotrop
Publikováno v:
Annals of the New York Academy of Sciences. 738:153-162
Autor:
Andrea Volterra, Claudia Verderio, Silvia Coco, Michela Matteoli, Jeffrey D. Rothstein, Davide Trotti
Publikováno v:
European Journal of Neuroscience. 9:1902-1910
It has been postulated for several years that the high affinity neuronal glutamate uptake system plays a role in clearing glutamate from the synaptic cleft. Four different glutamate transporter subtypes are now identified, the major neuronal one bein