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of 55
pro vyhledávání: '"Christopher L.-H. Huang"'
Transcriptional profiles of genes related to electrophysiological function in Scn5a+/− murine hearts
Autor:
Michael Takla, Charlotte E. Edling, Kevin Zhang, Khalil Saadeh, Gary Tse, Samantha C. Salvage, Christopher L.‐H. Huang, Kamalan Jeevaratnam
Publikováno v:
Physiological Reports, Vol 9, Iss 19, Pp n/a-n/a (2021)
Abstract The Scn5a gene encodes the major pore‐forming Nav1.5 (α) subunit, of the voltage‐gated Na+ channel in cardiomyocytes. The key role of Nav1.5 in action potential initiation and propagation in both atria and ventricles predisposes organis
Externí odkaz:
https://doaj.org/article/edef003b381440f3af65dbd7393d25d6
Autor:
Samantha C. Salvage, Taufiq Rahman, David A. Eagles, Johanna S. Rees, Glenn F. King, Christopher L‐H. Huang, Antony P. Jackson
Publikováno v:
Journal of Cellular Physiology.
Transcriptional profiles of genes related to electrophysiological function in Scn5a+/- murine hearts
Autor:
Samantha C. Salvage, Kamalan Jeevaratnam, Charlotte E. Edling, Michael Takla, Gary Tse, Khalil Saadeh, Christopher L.-H. Huang, Kevin Zhang
Publikováno v:
Physiological Reports, Vol 9, Iss 19, Pp n/a-n/a (2021)
Funder: University of Surrey; Id: http://dx.doi.org/10.13039/501100003513
The Scn5a gene encodes the major pore‐forming Nav1.5 (α) subunit, of the voltage‐gated Na+ channel in cardiomyocytes. The key role of Nav1.5 in action potential initi
The Scn5a gene encodes the major pore‐forming Nav1.5 (α) subunit, of the voltage‐gated Na+ channel in cardiomyocytes. The key role of Nav1.5 in action potential initi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1441935c644dcf3b2a59408139218e50
Publikováno v:
Annals of the New York Academy of Sciences. 1474:15-26
Bisphosphonates (BPs) are widely prescribed drugs used to treat osteoporosis, commonly arising in postmenopausal women and in chronic glucocorticoid use. Their mechanism of action is through inhibiting osteoclast-induced bone remodeling, and they als
Publikováno v:
Annals of the New York Academy of Sciences. 1433:18-28
Alterations in cellular levels of the second messenger 3',5'-cyclic adenosine monophosphate ([cAMP]i ) regulate a wide range of physiologically important cellular signaling processes in numerous cell types. Osteoclasts are terminally differentiated,
Autor:
Christopher L.-H. Huang, Kamalan Jeevaratnam, Samantha C. Salvage, Andrew A. Grace, Karan R. Chadda, Haseeb Valli, Shiraz Ahmad
Publikováno v:
Clinical and Experimental Pharmacology & Physiology
Summary Ageing is associated with increased prevalences of both atrial and ventricular arrhythmias, reflecting disruption of the normal sequence of ion channel activation and inactivation generating the propagated cardiac action potential. Experiment
Autor:
Karthik H Chandrasekharan, Samantha C. Salvage, Antony P. Jackson, Angela F. Dulhunty, Christopher L.-H. Huang, Kamalan Jeevaratnam, Andrew J. Thompson
Publikováno v:
British Journal of Pharmacology. 175:1260-1278
S.C.S. and A.P.J. are funded by the British Heart Foundation (PG/14/79/31102). K.J. is funded by the Fundamental Research Grant Scheme (FRGS/2/2014/SKK01/PERDANA/ 02/1), Ministry of Education, Malaysia and the Research Support Fund, Faculty of Health
Publikováno v:
Acta Physiologica. 216:186-202
Normal cardiac excitation involves orderly conduction of electrical activation and recovery dependent upon surface membrane, voltage-gated, sodium (Na(+) ) channel α-subunits (Nav 1.5). We summarize experimental studies of physiological and clinical
Autor:
Anders Riisager, Christopher L.-H. Huang, Rudy M Duehmke, Ole Bækgaard Nielsen, Thomas Holm Pedersen
Publikováno v:
The Journal of Physiology. 592:4417-4429
Recent studies in rat muscle fibres show that repetitive firing of action potentials causes changes in fibre resting membrane conductance (Gm) that reflect regulation of ClC-1 Cl(-) and KATP K(+) ion channels. Methodologically, these findings were ob
Autor:
Ming Lei, Yanmin Zhang, Laila Guzadhur, James A. Fraser, Kamalan Jeevaratnam, James King, Andrew A. Grace, Christopher L.-H. Huang, Xiaolei Ren, Jingjing Wu
Publikováno v:
Journal of Cardiovascular Electrophysiology. 24:210-218
INTRODUCTION: The familial condition catecholaminergic polymorphic ventricular tachycardia (CPVT) is characterized by episodic bidirectional ventricular tachycardia (BVT), polymorphic ventricular tachycardia (PVT), and ventricular fibrillation follow