Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Andres J. Klein-Szanto"'
Autor:
Joel Gabre, Jianwen Que, Angela J. Yoon, Ricardo Cruz-Acuna, Gary W. Falk, Shoji Natsugoe, Adam J. Bass, Julian A. Abrams, Tatiana A. Karakasheva, Lorenzo Ferri, Veena Sangwan, Anil K. Rustgi, Timothy C. Wang, Hiroshi Nakagawa, Varun Sahu, Kelly A. Whelan, Gregory G. Ginsberg, Elizabeth Philipone, J. Alan Diehl, Veronique Giroux, Hisatsugu Maekawa, Andres J. Klein-Szanto, Devraj Basu, Masataka Shimonosono, Takashi Kijima
Publikováno v:
Curr Protoc Stem Cell Biol
Esophageal cancers comprise adenocarcinoma and squamous cell carcinoma, two distinct histologic subtypes. Both are difficult to treat and among the deadliest human malignancies. We describe protocols to initiate, grow, passage, and characterize patie
Publikováno v:
Molecular Carcinogenesis. 56:1182-1188
Proprotein convertases (PCs) are serine proteases with an active role in the post-translational processing of numerous inactive proteins to active proteins including many substrates of paramount importance in cancer development and progression. Furin
Publikováno v:
Molecular Carcinogenesis. 54:1122-1131
PACE4 (PCSK6) is a proprotein convertase (PC) capable of processing numerous substrates involved in tumor growth, invasion, and metastasis. Because of the human relevancy of the tobacco-associated carcinogen benzo[a]pyrene (B(a)P) we investigated whe
Publikováno v:
Molecular Carcinogenesis. 54:698-706
Proprotein convertases (PC), a family of serine proteases, process cancer-related substrates such as growth factors, growth factor receptors, cell adhesion molecules, metalloproteinases, etc. HIF-1α is a major transcription factor involved in tumori
Autor:
Miriam N. Lango, Brian L. Egleston, Carolyn Y. Fang, Jamie L. Studts, Margret B. Einarson, Dana H. Bovbjerg, John A. Ridge, Andres J. Klein-Szanto, Barbara Burtness
Publikováno v:
Head & Neck. 36:1113-1119
Background Psychosocial functioning is associated with vascular endothelial growth factor (VEGF) in various patient populations. This study examined whether psychosocial functioning in patients with head and neck squamous cell carcinoma (HNSCC) is as
Autor:
Andres J. Klein-Szanto, Harry Subramanian, Shingo Kagawa, Azal Ahmadi, Shinya Ohashi, Hiroshi Nakagawa, Seiji Naganuma, Kei J. Nakagawa, Xinjun Ji, Stephen A. Liebhaber, Mitsuteru Natsuizaka, Sanders Chang
Publikováno v:
The FASEB Journal. 26:2620-2630
Insulin-like growth factor binding protein (IGFBP)-3 regulates cell proliferation and apoptosis in esophageal squamous cell carcinoma (ESCC) cells. We have investigated how the hypoxic tumor microenvironment in ESCC fosters the induction of IGFBP3. R
Autor:
Jonathan Chernoff, Karthik Devarajan, Stephen A. Boorjian, Yan Zhou, Andres J. Klein-Szanto, Igor Makhlin, Christopher J. Long, Jiaru Zhang, Min Huang
Publikováno v:
BJU International. 108:E84-E90
OBJECTIVE To investigate whether mammalian target of rapamycin (mTOR) inhibition by rapamycin is therapeutically efficacious in combination with cisplatin for bladder cancer. MATERIALS AND METHODS Using a panel of human urothelial carcinoma cell line
Autor:
Katherine A. High, Richard C. Austin, Jirko Kühnisch, Alexander Schlachterman, Michael Slifker, Šárka Lhoták, Aladdin Mustafa, Warren D. Kruger, Sapna Gupta, Andres J. Klein-Szanto
Publikováno v:
The FASEB Journal. 23:883-893
Untreated cystathionine β-synthase (CBS) deficiency in humans is characterized by extremely elevated plasma total homocysteine (tHcy>200 μM), with thrombosis as the major cause of morbidity. Treatment with vitamins and diet leads to a dramatic redu
Autor:
Hormoz Ehya, Edward R. Sauter, Colette C. Wagner-Mann, Brenda MacGibbon, Andres J. Klein-Szanto
Publikováno v:
Cancer. 103:914-921
BACKGROUND Fiberoptic ductoscopy (FD), which allows direct visualization of the breast ductal lumen, is performed in women with and without spontaneous nipple discharge (SND). Previous reports suggested that cytologic evaluation of SND may be falsely
Publikováno v:
Molecular Carcinogenesis. 44:151-161
Proprotein convertases (PCs) are a group of Ca2+-dependent serine proteases that have homology to the endoproteases subtilisin (bacteria) and kexin (yeast). This group is comprised of less than a dozen members, known as furin/PACE, PC1/PC3, PC2, PC4,