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pro vyhledávání: '"Albert E. Dahlberg"'
Capreomycin susceptibility is increased by TlyA-directed 2′-O-methylation on both ribosomal subunits
Publikováno v:
Molecular Microbiology. 85:1194-1203
The binding site of the cyclic peptide antibiotics capreomycin and viomycin is located on the ribosomal subunit interface close to nucleotides C1409 in 16S rRNA and C1920 in 23S rRNA. In Mycobacterium tuberculosis, the 2'-hydroxyls of both nucleotide
Publikováno v:
The EMBO Journal. 9:735-739
We have compared the influence of spectinomycin (Spc) on individual partial reactions during the elongation phase of translation in vitro by wild-type and mutant ribosomes. The data show that the antibiotic specifically inhibits the elongation factor
Publikováno v:
The EMBO Journal. 8:1213-1216
Two of six mutations at a base-paired site in Escherichia coli 16S rRNA confer resistance to nine different aminoglycoside antibiotics in vivo. Chemical probing of mutant and wild-type ribosomes in the presence of paromomycin indicates that interacti