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Autor:
Tracy M. Josephs, Le Vi Dinh, Aaron DeBono, Karen J. Gregory, Ben Capuano, Katie Leach, Andrew N. Keller
Publikováno v:
ChemMedChem. 16:3451-3462
The calcium-sensing receptor (CaSR) is a clinical target in the treatment of hyperparathyroidism and related diseases. However, clinical use of approved CaSR-targeting drugs such as cinacalcet ( 1 ) is limited due to adverse side effects including hy
Publikováno v:
European Journal of Pain. 25:2266-2277
BACKGROUND Exposure to stressful experiences is often accompanied by suppressing pain perception, referred to as stress-induced analgesia. The neuropeptides orexins are essential in regulating the mechanism that responds to stressful and painful stim
Publikováno v:
ESC Heart Failure, Vol 8, Iss 3, Pp 1979-1989 (2021)
ESC Heart Failure
ESC Heart Failure
Aims Prostaglandin E2 (PGE2) is involved in the development of cardiac hypertrophy. However, whether PGE2 regulates the chronic kidney disease‐associated cardiac hypertrophy and the tentative mechanism remains to be elucidated. Methods and results
Autor:
Michael Yu-Chih Chen, Ray-Jade Chen, Chih Yang Huang, Ping-Ling Chiu, Hsiang‐Chen Lee, Cecilia Hsuan Day, Hsiang-Ning Luk, Bruce Chi-Kang Tsai, Wen-Yuan Lin, V. Vijaya Padma
Publikováno v:
Environmental Toxicology. 36:1567-1575
Habitual chewing of areca nut increases the risk of cardiovascular disease mortality, but less report demonstrate the toxic mechanism of areca nut on heart. To investigate toxicity of areca nut on cardiomyocytes, we induced the heart injury with arec
Autor:
Guoqing Wan, Xuefeng Gu, Yingying Wang, Wenhui Huang, Nian-Hong Chen, Yuhan Bi, Yu Yang, Keshen Li
Publikováno v:
Basic & Clinical Pharmacology & Toxicology. 128:758-772
MiRNAs are small, non-coding RNAs that can silence the expression of various target genes by binding their mRNAs and thus regulate a wide range of crucial bodily functions. However, the miRNA expression profile of schizophrenia after antipsychotic me
Autor:
Thoralf Opitz, Heinz Beck, Leonie Pothmann, Sarah Schmidt, Daniel Müller-Komorowska, Patrício Soares da Silva
Publikováno v:
Epilepsia. 62:542-556
Objective Many antiseizure drugs (ASDs) act on voltage-dependent sodium channels, and the molecular basis of these effects is well established. In contrast, how ASDs act on the level of neuronal networks is much less understood. Methods In the presen
Autor:
Robert Seaman, Yanan Zhang, Jian-Feng Liu, Bernard Johnson, Ruyan Wu, Jimmy Vu, Jun-Xu Li, Jingwei Tian
Publikováno v:
Br J Pharmacol
Background and purpose Trace amine-associated TA1 receptors play critical roles in regulating dopamine transmission. Previous studies showed that pharmacologically or genetically manipulating the activity of TA1 receptors modulates addiction-like beh
Autor:
Michael P. Wiggs, Bumsoo Ahn, Stephanie E. Hall, Aaron B. Morton, Ashley J. Smuder, J. Matthew Hinkley, Scott K. Powers, Hayden W. Hyatt, Kurt J. Sollanek
Publikováno v:
Clinical and Translational Science
Clinical and Translational Science, Vol 14, Iss 2, Pp 481-486 (2021)
Clinical and Translational Science, Vol 14, Iss 2, Pp 481-486 (2021)
Mechanical ventilation (MV) is a life‐saving intervention for many critically ill patients. Unfortunately, prolonged MV results in the rapid development of inspiratory muscle weakness due to diaphragmatic atrophy and contractile dysfunction (termed
Autor:
Na Liu, Jiaxing Sun, Xin Zhang, Wenxiu Liu, Xue Ding, Xinhua Yin, Yutong Guo, Ningning Kang, Jinyu Chi, Yue Liu
Publikováno v:
Journal of Cellular and Molecular Medicine
The calcium‐sensing receptor (CaSR) is involved in the pathophysiology of many cardiovascular diseases, including myocardial infarction (MI) and hypertension. The role of Calhex231, a specific inhibitor of CaSR, in myocardial fibrosis following MI
Autor:
Keywan Mortezaee, Homayoon Bana Derakhshan, Jamal Majidpoor, Reza Shirazi, Alireza Zali, Fardin Fathi, Mohammad Taghi Joghataie, Fatemeh Moradi, Mehdi Ghasemzadeh Bariki, Zahra Khezri
Publikováno v:
Cell Biochemistry and Function. 39:267-276
Spinal cord injury (SCI) is a common devastating condition that causes neuronal loss and dysfunction. Neuroinflammation takes cardinal roles in the pathogenesis of SCI, and nucleotide-binding domain-like receptor protein 3 (NLRP3) inflammasome is a m