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Autor:
Yuma A. Bijleveld, Adam F. Cohen, Michiel J van Esdonk, Gertjan J. Driessen, Anton H. van Kaam, Matthijs D. Kruizinga, Ron A. A. Mathôt, Willemijn van Heel, Rik F E Stuurman, Younes Tallahi, Amadou Samb, Timo R. de Haan
Publikováno v:
British Journal of Clinical Pharmacology, 88(4), 1845-1855. Wiley
British journal of clinical pharmacology. Wiley-Blackwell
British journal of clinical pharmacology. Wiley-Blackwell
Aims Therapeutic drug monitoring (TDM) of gentamicin in neonates is recommended for safe and effective dosing and is currently performed by plasma sampling, which is an invasive and painful procedure. In this study, feasibility of a non-invasive gent
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 11, Iss 2, Pp 225-239 (2022)
Oxcarbazepine (OXZ) and levetiracetam (LEV) are two new generation anti‐epileptic drugs, often co‐administered in children with enzyme‐inducing antiepileptic drugs (EIAEDs). The anti‐epileptic effect of OXZ and LEV are linked to the exposure
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 11, Iss 2, Pp 199-211 (2022)
Finerenone is a nonsteroidal, selective mineralocorticoid receptor antagonist (MRA) that recently demonstrated its efficacy to delay chronic kidney disease (CKD) progression and reduce cardiovascular events in patients with CKD and type 2 diabetes. H
Autor:
Tsuyoshi Ohnishi, Roland C.K. Ng, Miho Kimachi, Yan Luo, Norihiro Nishioka, Norio Watanabe, Takuya Taniguchi
Publikováno v:
Cochrane Database Syst Rev
Carnitine deficiency is common in patients with chronic kidney disease (CKD) who require dialysis. Several clinical studies have suggested that carnitine supplementation is beneficial for dialysis-related symptoms. However, the clinical effectiveness
Autor:
Kateryna Kovalenko, Yoonsun Mo, Natalia Shcherbakova, Wai Kin Li, Joshua Rosenberg, Kelsey L. Inman, Jose Orsini
Publikováno v:
The Journal of Clinical Pharmacology. 62:359-365
The use of population pharmacokinetics (PK) to optimize cefepime dosing could be an effective strategy, given the increasing prevalence of resistant gram-negative organisms. The objective of this study is to retrospectively compare dosing using PK ap
Publikováno v:
The Journal of Clinical Pharmacology. 62:646-655
This study aimed to characterize adverse drug reactions (ADRs) to hydroxychloroquine in the setting of Covid-19, occurring in Italy in the period March-May 2020. The analysis of the combination therapy with azithromycin or/and lopinavir/ritonavir as
Risk of Pregabalin‐Induced Hypoglycemia: Analysis of the Japanese Adverse Drug Event Report Database
Autor:
Masashi Neo, Junko Makino, Kaoru Suzuki, Masami Nishihara, Tomoyuki Yamada, Satoru Mitsuboshi
Publikováno v:
The Journal of Clinical Pharmacology. 62:756-761
Pregabalin is a first-line treatment option for neuropathic pain. Recently, some cases of pregabalin-induced hypoglycemia have been reported, which can complicate the treatment of neuropathic pain and worsen patient outcomes. Therefore, a better unde
Publikováno v:
The Journal of Clinical Pharmacology. 62:594-608
Anti-vascular endothelial growth factor (VEGF) therapy is used to slow the disease progression of neovascular age-related macular degeneration. Due to the treatment burden of frequent intravitreal injections, anti-VEGFs are often used on treat and ex
Publikováno v:
The Journal of Clinical Pharmacology. 62:631-635
The association between the use of sodium-glucose co-transporter-2 (SGLT-2) inhibitors and the occurrence of drug-induced kidney injury has not been evaluated. This study assessed whether the use of SGLT-2 inhibitors decreases the risk of drug-induce
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 11, Iss 1, Pp 55-67 (2022)
CPT: Pharmacometrics & Systems Pharmacology
CPT: Pharmacometrics & Systems Pharmacology
As one of the key components in model‐informed drug discovery and development, physiologically‐based pharmacokinetic (PBPK) modeling linked with in vitro‐to‐in vivo extrapolation (IVIVE) is widely applied to quantitatively predict drug–drug