Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Christopher L.-H. Huang"'
Publikováno v:
Annals of the New York Academy of Sciences. 1433:18-28
Alterations in cellular levels of the second messenger 3',5'-cyclic adenosine monophosphate ([cAMP]i ) regulate a wide range of physiologically important cellular signaling processes in numerous cell types. Osteoclasts are terminally differentiated,
Autor:
Anders Riisager, Christopher L.-H. Huang, Rudy M Duehmke, Ole Bækgaard Nielsen, Thomas Holm Pedersen
Publikováno v:
The Journal of Physiology. 592:4417-4429
Recent studies in rat muscle fibres show that repetitive firing of action potentials causes changes in fibre resting membrane conductance (Gm) that reflect regulation of ClC-1 Cl(-) and KATP K(+) ion channels. Methodologically, these findings were ob
Autor:
Christopher L.-H. Huang
Publikováno v:
British Journal of Pharmacology. 170:486-488
Sarcoplasmic reticular (SR) Ca2+-ATPase (SERCA2a) is central to cardiac electrophysiological and mechanical function. It ensures full diastolic relaxation minimizing delayed after-potentials that would otherwise compromise membrane electrophysiologic
Publikováno v:
Biological Reviews. 84:143-159
Regulation of cell volume is a fundamental property of all animal cells and is of particular importance in skeletal muscle where exercise is associated with a wide range of cellular changes that would be expected to influence cell volume. These compl
Publikováno v:
Annals of the New York Academy of Sciences. 1116:255-270
This review compares ryanodine receptor (RyR)-mediated Ca(2+) signaling processes in muscle and osteoclast cells. In muscle, RyR-mediated release of an intracellularly stored, sarcoplasmic reticular (SR), Ca(2+) is triggered by voltage-sensitive dihy
Autor:
Christopher L.-H. Huang, James A. Fraser, Peter S. J. Bailey, Julian L. Griffin, Juliet A. Usher-Smith
Publikováno v:
The Journal of Physiology. 573:799-818
The combined effects of intracellular lactate and proton accumulation on cell volume, Vc, were investigated in resting Rana temporaria striated muscle fibres. Intracellular lactate and H+ concentrations were simultaneously increased by exposing resti
Autor:
Anne Royer, Aiqun Ma, Christopher L.-H. Huang, Anne Laure Leoni, Guosheng Xiao, William H. Colledge, Henggui Zhang, C. A. Goddard, Jie Liu, Jaime I. Vandenberg, Simon S M Fung, Ming Lei, Andrew A. Grace, Flavien Charpentier
Publikováno v:
The Journal of Physiology. 567:387-400
We have examined sino-atrial node (SAN) function in hearts from adult mice with heterozygous targeted disruption of the Scn5a gene to clarify the role of Scn5a-encoded cardiac Na+ channels in normal SAN function and the mechanism(s) by which reduced
Publikováno v:
The Journal of Physiology. 564:51-63
The influence of extracellular hypotonicity on the relationship between cell volume (Vc) and resting membrane potential (Em) was investigated in Rana temporaria skeletal muscle. Vc was measured by confocal microscope imaging of fibres through their t
Autor:
James A. Fraser, Christof J. Schwiening, Claire E. Middlebrook, Juliet A. Usher-Smith, Christopher L.-H. Huang
Publikováno v:
The Journal of Physiology. 563:745-764
The relationship between cell volume (Vc) and membrane potential (Em) in Rana temporaria striated muscle fibres was investigated under different conditions of intracellular acidification. Confocal microscope xz-scanning monitored the changes in Vc, w