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Autor:
Ewen MacDonald
Publikováno v:
Acta Pharmacologica et Toxicologica. 54:76-80
The pithed rat preparation was used to study the effects of copper (as cupric chloride) on the release and re-uptake of noradrenaline from sympathetic nerves. At the highest concentration which could be tested without failure of the preparation, ther
Publikováno v:
Acta Pharmacologica et Toxicologica. 56:63-68
The interaction between chlorpromazine (CPZ) and lithium on renal concentrating ability was studied in rats fed a Li-containing diet for 8 weeks (plasma-Li 0.6-0.7 mmol/l). CPZ (15 mg/kg daily orally) reduced the polydipsia and increased the ability
Publikováno v:
Acta Pharmacologica et Toxicologica. 59:175-178
Embryotoxic and teratogenic effects of cadmium and lindane were studied in rats. Cadmium or lindane alone did not produce any significant malformations in the 20 day old foetuses whereas their combination caused significant reduction in the body weig
Publikováno v:
Acta Pharmacologica et Toxicologica. 58:61-70
A number of potential neuroleptic drugs of the substituted benzamide type have been compared with some reference neuroleptic drugs regarding their affinities for rat brain receptors using in vitro receptor binding techniques. The effects on dopamine-
Autor:
Lena A. C. Smith, Bengt J. Meyerson
Publikováno v:
Acta Pharmacologica et Toxicologica. 55:194-198
The effect of lysergic acid diethylamide (LSD) on copulatory and exploratory behaviour in hormone-treated, ovariectomized rats was investigated 4 weeks after chronic treatment with either saline or zimeldine (ZIM). A decrease in sensitivity to the lo
Autor:
Amdi Amdisen, Donald F. Smith
Publikováno v:
Acta Pharmacologica et Toxicologica. 52:81-85
Male rats received LiCl for one week either by continuous intracerebroventricular injection from osmotic minipumps or by oral administration in the diet. Control groups received corresponding treatment with NaCl. The intracerebroventricular lithium t
Publikováno v:
Acta Pharmacologica et Toxicologica. 51:309-320
Rats under pentobarbitone anaesthesia, pancuronium relaxation and artificial ventilation with constant volume, were given methacholine (MeCh) 4, 6, and 9 micrograms intravenously at 2 min. intervals; the rise in intratracheal pressure indicated bronc
Publikováno v:
Acta Pharmacologica et Toxicologica. 49:161-167
The effects of 8 weeks of treatment with lithium and neuroleptics, alone and combined, on renal concentrating ability and morphology were studied in rats. LiCl was administered in the diet and neuroleptics were given as one daily dose: haloperidol 1
Autor:
A. Geisler, Sten Christensen
Publikováno v:
Acta Pharmacologica et Toxicologica. 40:447-454
The antidiuretic and urinary cyclic AMP response to supramaximal vasopressin infusion was studied in normal rats and in rats with lithium-polyuria. The animals were anaesthetized and then infused with a solution designed to produce excessive water di
Publikováno v:
Acta Pharmacologica et Toxicologica. 55:391-397
D2343 is a compound with about the same beta 2-adrenoceptor-agonist effect as terbutaline and exhibiting in addition an alpha 1-receptor inhibitory activity. D2343 has been compared to the beta 2-agonist terbutaline on oestrogenized uterine preparati