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Regulation of human cripto-1 gene expression by TGF-β1 and BMP-4 in embryonal and colon cancer cells
Autor:
Nicola Normanno, Caterina Bianco, Kazuhide Watanabe, Monica Gonzales, Luigi Strizzi, Christian Wechselberger, Mario Mancino, Shin Hamada, David S. Salomon
Publikováno v:
Journal of Cellular Physiology. 215:192-203
Human Cripto-1 (CR-1) is a cell membrane protein that is overexpressed in several different types of human carcinomas. In the present study we investigated the mechanisms that regulate the expression of CR-1 gene in cancer cells. We cloned a 2,481 bp