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Autor:
Andrew D. Rule, Kianoush Kashani, Carrie A. Thompson, Joel M. Reid, Thomas E. Witzig, Nelson Leung, Renee M. McGovern, Kristin C. Mara, Erin F. Barreto, Thomas R. Larson, Jason N. Barreto
Publikováno v:
Clinical and Translational Science, Vol 15, Iss 1, Pp 105-117 (2022)
Clinical and Translational Science
Clinical and Translational Science
High‐dose methotrexate (HDMTX) pharmacokinetics (PKs), including the best estimated glomerular filtration rate (eGFR) equation that reflects methotrexate (MTX) clearance, requires investigation. This prospective, observational, single‐center stud
Autor:
Manna Zhang, Diliqinna Dilimuzhati, Xiaowen Shao, Shen Qu, Feng Xing, Meili Cai, Qiongjing Zeng, Yuqin Zhang, Xinyu Gao
Publikováno v:
Diabetes, Obesity and Metabolism. 24:312-320
Objectives This study aimed to determine the safety and efficacy of canagliflozin in comparison to metformin in polycystic ovary syndrome (PCOS) patients with insulin resistance (IR). Methods A single center, prospective, randomized open-label (ratio
Autor:
Stéphane Horlait, Donald Betah, Jacques P. Brown, Cesar Libanati, Yifei Shi, Rogely W. Boyce, Erik Fink Eriksen, Pascale Chavassieux, Roland Chapurlat
Publikováno v:
Journal of Bone and Mineral Research. 37:36-40
The bone-forming agent romosozumab is a monoclonal antibody that inhibits sclerostin, leading to increased bone formation and decreased resorption. The highest levels of bone formation markers in human patients are observed in the first 2 months of t
Autor:
Saori Majima, Masahide Hamaguchi, Mai Asano, Tomoki Miyoshi, Hanako Nakajima, Yoshitaka Hashimoto, Hiroshi Okada, Takuro Okamura, Emi Ushigome, Takafumi Osaka, Naoko Nakanishi, Shinnosuke Hata, Michiaki Fukui, Yukako Hosomi, Masahiro Yamazaki, Takafumi Sennmaru
Publikováno v:
Journal of Diabetes Investigation. 13:489-500
AIMS/INTRODUCTION Metformin is associated with the risk of gastrointestinal complications, and probiotic Bifidobacterium bifidum G9-1 (BBG9-1) can improve the symptoms of diarrhea. This study aimed to clarify the effects of probiotic BBG9-1 on the ga
Autor:
Marco Pavesi, Moisés Mira Flores, Aurea Duran, Josep Gumà, Alessandra Pranzo, Alexis Serikoff, Bernard Rappe, Angus Robinson, Serena Hilman, Benoit Baron, Louis-Marie Dourthe, D. Mott, Steven Joniau, M. Herdman, Stéphane Mallick, Roberto Bordonaro, Maria De Santis, Ugo De Giorgi, Heather Payne
Publikováno v:
International Journal of Cancer. 150:837-846
In randomized clinical trials, the androgen-receptor inhibitor enzalutamide has demonstrated efficacy and safety in metastatic castration-resistant prostate cancer (mCRPC). This study captured efficacy, safety and patient-reported outcomes (PROs) of
Publikováno v:
Journal of Diabetes Investigation, Vol 12, Iss 11, Pp 1983-1991 (2021)
Journal of Diabetes Investigation
Journal of Diabetes Investigation
Aims/Introduction To evaluate and compare the efficacy of insulin degludec (IDeg) and insulin glargine 300 U/mL (Gla300) 6 months after switching from other basal insulins by assessing the changes in glycated hemoglobin (HbA1c), body mass index (BMI)
Autor:
Kimiyo Raymond, William Brucker, Anna N. Ligezka, Austin Larson, David Cassiman, Devin Oglesbee, Tamas Kozicz, Kishore Garapati, Renee M. McGovern, Ethan O. Perlstein, Wasantha Ranatunga, Christina Lam, Silvia Radenkovic, Mayank Saraswat, Joel M. Reid, Graeme Preston, Karthik Muthusamy, Christin Johnsen, Andrew C. Edmondson, Wirginia Krzysciak, Bart Ghesquière, Eva Morava, Saadet Mercimek-Andrews, Hitoshi Yanaihara, Akhilesh Pandey, Peter Witters
Publikováno v:
Ann Neurol
OBJECTIVE: Epalrestat, an aldose reductase inhibitor increases phosphomannomutase (PMM) enzyme activity in a PMM2-congenital disorders of glycosylation (CDG) worm model. Epalrestat also decreases sorbitol level in diabetic neuropathy. We evaluated th
Autor:
Steve Vucic, Merrilee Needham, Robert D. Henderson, Matthew C. Kiernan, David Schultz, Susan Mathers
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 8, Iss 10, Pp 1991-1999 (2021)
Annals of Clinical and Translational Neurology
Annals of Clinical and Translational Neurology
Objective Neuroinflammation is an important pathogenic mechanism in amyotrophic lateral sclerosis (ALS), with regulatory T cells (Tregs) mediating a slower rate of disease progression. Dimethyl fumarate enhances Treg levels and suppresses pro-inflamm
Autor:
Pankaj Jorwal, Surabhi Vyas, Sanjeev Sinha, Puneet Khanna, Animesh Ray, Immaculata Xess, Satish Swain, Naveet Wig, Radhika Sarda, Anjan Trikha, Gagandeep Singh, Parul Kodan
Publikováno v:
Mycoses
Background Though invasive pulmonary aspergillosis is a well known complication of COVID‐19 pneumonia, indolent forms of aspergillosis have been rarely described. Methods We prospectively collected the clinico‐radio‐microbiological data of 10 p
Autor:
Ramona Nudischer, Adrian Roth, Vanessa Baier, Lars M. Blank, José V. Castell, Jens M. Kelm, Annika R. P. Schneider, Florian Caiment, Hans Gmuender, Christoph Thiel, Lars Kuepfer, Wolfgang Moritz, Yannick Schrooders, Henrik Cordes, Jos C. S. Kleinjans, Christian Trautwein, Timo Wittenberger, Olivia Clayton, Ulf P. Neumann
Publikováno v:
Clinical pharmacology & therapeutics : CPT 110(5), 1293-1301 (2021). doi:10.1002/cpt.2406
Clinical Pharmacology & Therapeutics, 110(5), 1293-1301. Wiley
CLINICAL PHARMACOLOGY & THERAPEUTICS
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
instname
Clinical Pharmacology & Therapeutics, 110(5), 1293-1301. Wiley
CLINICAL PHARMACOLOGY & THERAPEUTICS
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
instname
We present a generic workflow combining physiology-based computational modeling and in vitro data to assess the clinical cholestatic risk of different drugs systematically. Changes in expression levels of genes involved in the enterohepatic circulati