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Autor:
Jason S. Knight, Medha Barbhaiya, Hannah Cohen, Michelle Petri, Robert Roubey, Maria Efthymiou, Rohan Willis, Doruk Erkan, Vittorio Pengo, Esther Rodriguez, Amaia Ugarte, Ecem Sevim, Maria Laura Bertolaccini, Paul R. Fortin, H. Michael Belmont, Ricard Cervera, Diane Zisa, Lanlan Ji, Tatsuya Atsumi, Maria Gerosa, D. Ware Branch, Savino Sciascia, Aps Action Investigators, Guilherme Ramires de Jesus, Maria Angeles Aguirre Zamorano, Laura Andreoli, Maria G Tektonidou, Danieli Andrade
Publikováno v:
Arthritis Care & Research. 74:324-335
To describe the baseline characteristics of patients with positivity for antiphospholipid antibodies (aPLs) who were enrolled in an international registry, the Antiphospholipid Syndrome (APS) Alliance for Clinical Trials and International Networking
Publikováno v:
British Journal of Clinical Pharmacology. 88:1942-1946
Dapagliflozin is an inhibitor of human renal sodium-glucose cotransporter 2 (SGLT2), first approved for the treatment of type 2 diabetes mellitus (T2DM). Dapagliflozin is primarily metabolized by uridine diphosphate glucuronosyltransferase 1A9 (UGT1A
Autor:
Marko Pregel, Jia Liu, Edward B. Stevens, Yiting Wang, David N. Sheppard, Walailak Jantarajit, Lishuang Cao, Allison P. Berg, Katy J. Sutcliffe
Publikováno v:
British Journal of Pharmacology. 179:1319-1337
BACKGROUND AND PURPOSE Cystic fibrosis transmembrane conductance regulator (CFTR) potentiators are small molecules developed to treat the genetic disease cystic fibrosis (CF). They interact directly with CFTR Cl- channels at the plasma membrane to en
Autor:
Ting-An Chou, Yi-Fang Huang, Chung-Yi Nien, Hsiang-Hsi Hong, Chao-Hua Liang, Adrienne Hong, Hui-Yi Hsiao, Tzung-Hai Yen, Alex Hong
Publikováno v:
Journal of Periodontology. 93:1553-1565
BACKGROUNDS Alveolar bone and cementum share many biological and developmental similarities. The mineralizing effect of calcitriol has been previously reported. Yet, its cementoinductivity has not been confirmed. This study evaluated the potential ce
Publikováno v:
Environmental Toxicology and Chemistry. 41:396-409
The derivation of protective values for aquatic life can be enhanced by the development and use of bioavailability models. Recent advances to metals bioavailability modeling are applicable to other analyte groups and should be widely considered. In t
Autor:
Yi Yang, Robyn T. Domsic, Christina Morse, Tracy Tabib, Robert Lafyatis, Dinesh Khanna, Dan Xue
Publikováno v:
Arthritis & Rheumatology. 74:329-341
In this study, we sought a comprehensive understanding of myeloid cell types driving fibrosis in diffuse cutaneous systemic sclerosis (dcSSc) skin.We analyzed the transcriptomes of 2,465 myeloid cells from skin biopsy specimens from 12 dcSSc patients
Publikováno v:
Oral Diseases. 29:902-912
Objectives The dysregulation of circular RNAs (circRNAs) is implicated in the progression of various cancers. This study was aimed at expounding the role and mechanism of hsa_circ_0002141 in the OSCC progression. Materials and methods Circ_0002141 ex
Publikováno v:
British Journal of Pharmacology. 179:1125-1145
Fungal infections cause serious problems in many aspects of human life, in particular infections in immunocompromised patients present serious problems. Current anti-fungal antibiotics target various metabolic pathways, predominantly the cell wall or
Autor:
K Gopalakrishnan, Sushrita Roy Muhury, Parinitha Parameshwar, Sehbanul Islam, Parul Dutta, Manas Kumar Santra, Praveenkumar Shetty, Osheen Sahay
Publikováno v:
International Journal of Cancer. 150:1512-1524
FBXO31, a member of F-box protein family, has been shown to play an important role in preventing tumorigenesis by preserving genomic stability during cell proliferations as well as upon genotoxic stresses. Inactivation of FBXO31 due to loss of hetero
Autor:
Hossein Pashaiefar, Seyyedeh Masoomeh Noorbakhsh, Soheil Najafi, Mohammad Reza Nikouei Moghaddam, Nahid Beladi Moghadam, Monireh Movahedi, Abbas Mirshafiey, Ali Manoucherinia, Zahra Aghazadeh, Anita Vali Mohammadi, Payam Saadat
Publikováno v:
The Journal of Clinical Pharmacology. 62:762-769
Multiple sclerosis (MS) is a chronic neurologic disease defined by inflammation and demyelination of the central nervous system that comes with variable degrees of axonal and neuronal damage. The efficacy of β-D-mannuronic acid (M2000) as a novel dr