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Publikováno v:
The Journal of Gene Medicine.
Background Prostate cancer (PCa) is a heavy health-threat for human worldwide. Recent studies revealed that microRNAs (miRNAs) are associated with the progression of human cancers, including PCa. However, no study has been performed to investigate th
Publikováno v:
The Journal of Gene Medicine. 25
Background Glucocorticoid Modulatory Element-Binding protein 1 (GMEB1) suppresses caspase-mediated cell apoptosis. microRNA-320 (miR-320a) can inhibit tumor development by arresting tumor cell invasion. To our best knowledge, no previous study focuse
Autor:
Manuel Sobrinho-Simões, Silke Haim, Leonardo Caporali, Monica De Luise, Oleksiy Tsybrovskyy, Dario de Biase, Giuseppe Gasparre, Valerio Carelli, Dominik Hackl, Claudio Fiorini, Giovanni Tallini, Larisa Imamovic
Publikováno v:
The Journal of Pathology: Clinical Research, Vol 8, Iss 2, Pp 155-168 (2022)
Papillary thyroid carcinoma tall cell variant (PTC-TCV), a form of PTC regarded as an aggressive subtype, shares several morphologic features with oncocytic tumors. Pathogenic homoplasmic/highly heteroplasmic somatic mitochondrial DNA (mtDNA) mutatio
Publikováno v:
IET Systems Biology, Vol 16, Iss 1, Pp 28-41 (2022)
Stroke is one of the leading causes of patients' death and long‐term disability worldwide, and ischaemic stroke (IS) accounts for nearly 80% of all strokes. Differential genes and weighted gene co‐expression network analysis (WGCNA) in male and f
Autor:
Suman Sinha, Anamika Biswas, Mrinal Kanti Bhattacharyya, Kalyaneswar Mandal, Irshad Ali, Jamsad Mannuthodikayil, Sameer Singh, Purna Chandra Mashurabad, Pratap Vydyam, Wahida Tabassum
Publikováno v:
ChemBioChem. 24
Inhibition of tight junction formation between two malaria parasite proteins, apical membrane antigen 1 and rhoptry neck protein 2, crucial for red blood cell invasion, prevents the disease progression. In this work, we have utilized a unique approac
Publikováno v:
Molecular Microbiology. 117:411-428
Bacteria that exhibit polar growth, i.e. build their peptidoglycan cell walls in restricted zones at cell poles, often show large morphological diversity and plasticity. However, their mechanisms for regulation of cell shape and cell wall assembly ar
Autor:
Hermann J. Girschick, Henner Morbach, Julia Klaussner, Johannes Dirks, Stephan Hackenberg, Jonas Fischer, Gabriele Haase, Annette Holl-Wieden, Christine Hofmann
Publikováno v:
Arthritis & Rheumatology. 74:150-162
Objectives Antinuclear antibody (ANA) positive Juvenile Idiopathic Arthritis (JIA) is characterized by synovial B cell hyperactivity, but the precise role of CD4+ T cells in promoting local B cell activation is unknown. The objective of this study is
Autor:
Rongsheng Jin, Peng Chen
Publikováno v:
The FEBS Journal. 290:962-969
Clostridioides difficile is classified as an urgent antibiotic resistance threat by the Centers for Disease Control and Prevention (CDC). C. difficile infection (CDI) is mainly caused by the C. difficile exotoxin TcdB, which invades host cells via re
Autor:
Hamood AlSudais, Nadine Wiper-Bergeron
Publikováno v:
The FEBS Journal. 289:6518-6530
CCAAT/Enhancer Binding protein beta (C/EBPβ) is a transcriptional regulator involved in numerous physiological processes. Herein, we describe a role for C/EBPβ as a regulator of skeletal muscle stem cell function. In particular, C/EBPβ is expresse
Autor:
Keiichiro Mine, Soroku Yagihashi, Akira Takeshita, Tomoyasu Fukui, Seiho Nagafuchi, Tetsuro Kobayashi, Erika Jimbo
Publikováno v:
Journal of Diabetes Investigation. 13:435-442
Introduction The need for antiserum for immunohistochemical detection (IHC) of enterovirus (EV) in formaldehyde fixed and paraffin-embedded (FFPE) samples is increasing. The gold standard monoclonal antibody (clone 5D8/1) against EV-envelope protein