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Autor:
Suman Sinha, Anamika Biswas, Mrinal Kanti Bhattacharyya, Kalyaneswar Mandal, Irshad Ali, Jamsad Mannuthodikayil, Sameer Singh, Purna Chandra Mashurabad, Pratap Vydyam, Wahida Tabassum
Publikováno v:
ChemBioChem. 24
Inhibition of tight junction formation between two malaria parasite proteins, apical membrane antigen 1 and rhoptry neck protein 2, crucial for red blood cell invasion, prevents the disease progression. In this work, we have utilized a unique approac
Autor:
Irene Hjorth Jacobsen, Douglas B. Kell, José L. Martínez, Steven Axel van der Hoek, Irina Borodina, Matej Rusnák
Publikováno v:
van der Hoek, S A, Rusnák, M, Jacobsen, I H, Martínez, J L, Kell, D B & Borodina, I 2022, ' Engineering ergothioneine production in Yarrowia lipolytica ', FEBS Letters, vol. 596, no. 10, pp. 1356-1364 . https://doi.org/10.1002/1873-3468.14239
Ergothioneine is a naturally occurring antioxidant that has shown potential in ameliorating neurodegenerative and cardiovascular diseases. In this study, we investigated the potential of the Crabtree-negative, oleaginous yeast Yarrowia lipolytica as
Autor:
Miaomiao Tian, Yu Zhao, Jing Zhang, Yao Zhou, Shuangshuang Le, Yongzhan Nie, Xianchun Gao, Wenjiao Li, Kun Liu, Xin Fu, Renlong Li, Haohao Zhang, Jiehao Zhang, Lijun Lou, Yan Li
Publikováno v:
FEBS Letters. 596:128-145
The prevalence of non-alcoholic fatty liver disease (NAFLD) increases with aging. However, the mechanism of aging-related NAFLD remains unclear. Herein, we constructed an aging-related hepatic steatosis model and analyzed the differentially expressed
Autor:
Esmail Pagheh, Seyyed Morteza Hoseini, Hien Van Doan, Seyed Hossein Hoseinifar, Ali Taheri Mirghaed
Publikováno v:
Journal of Experimental Zoology Part A: Ecological and Integrative Physiology. 337:227-237
The aim of this study was to assess the anesthetic efficacy and biochemical effects of citronellal on rainbow trout, Oncorhynchus mykiss. The fish were exposed to 200-800 µl/L citronellal to find the anesthesia induction and recovery times. The deep
Autor:
Giyeol Han, Dong Gun Lee
Publikováno v:
IUBMB Life. 74:235-244
Indole propionic acid (IPA) which majorly influences the modulation of cellular respiration is a metabolite generated by gut microbiota. The antimicrobial effects of IPA have not been previously demonstrated. Therefore, this study focused on investig
Publikováno v:
Cancer Science
Cancer susceptibility is a critical factor in the understanding of carcinogenesis. Intraperitoneal (i.p.) injection of an iron chelate, ferric nitrilotriacetate (Fe‐NTA), produces hydroxyl radicals via Fenton reaction to induce ferroptosis in renal
Autor:
Ezhilarasan Devaraj, Geetha Rv, Kamal Dua, Lakshmi Thangavelu, Sri Renukadevi Balusamy, Dinesh Kumar Chellappan
Publikováno v:
Environmental Toxicology. 37:446-456
Acacia catechu Willd (Fabaceae) is a thorny tree widely distributed in India and commonly used as traditional Ayurvedic medicine for various ailments. The current study evaluates the cytotoxic potentials of A. catechu ethanolic seed extract (ACSE) in
Autor:
Hideyuki Sasaki, Robert M. Blanton, Kazutaka Ueda, Richard H. Karas, Dong Ik Lee, Nazareno Paolocci, Brian O'Rourke, Michael E. Mendelsohn, Masaki Hashimoto, David A. Kass, Guangshuo Zhu, Yuan Yuan, Masayuki Sasaki, Eiki Takimoto, Djahida Bedja, Taro Kariya, Manling Zhang, Matthew Gabrielson, Nina Kaludercic
Publikováno v:
FEBS Lett
Phosphodiesterase 5 inhibition (PDE5i) activates cGMP-dependent protein kinase (PKG) and ameliorates heart failure; however, its impact on cardiac mitochondrial regulation has not been fully determined. Here, we investigated the role of the mitochond
Autor:
Rodrigo Rocco, Rosa Wainstok, Hernán Reingruber, Adrián E. Cambindo Botto, Adriana C. Cochón, Manuel J. Muñoz, Silvina Gazzaniga
Publikováno v:
Experimental Dermatology. 31:608-614
The off-label use of imiquimod (IQ) for hemangioma treatment has shown clinical benefits. We have previously reported a selective direct IQ-cytotoxic effect on transformed (H5V) vs. normal (1G11) endothelial cells (EC). In the present study, we inves
Publikováno v:
FEBS Letters
Pellino-2 is an E3 ubiquitin ligase that mediates intracellular signaling in innate immune pathways. Most studies of endogenous Pellino-2 have been performed in macrophages, but none in nonimmune cells. Using yeast two-hybrid screening and co-immunop