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Autor:
Heike Vogel, Suzanne L. Dickson, Tina Bake, Christian E. Edvardsson, Marie V. Le May, Ulrika Bergström, Imre Farkas, Zsolt Liposits, Karolina P. Skibicka, Marjorie Nicholson Albers
Publikováno v:
Obesity. 28:1503-1511
OBJECTIVE The lateral parabrachial nucleus (lPBN) in the brainstem has emerged as a key area involved in feeding control that is targeted by several circulating anorexigenic hormones. Here, the objective was to determine whether the lPBN is also a re
Publikováno v:
British Journal of Pharmacology. 177:2240-2255
Improved understanding of brain mechanisms regulating endogenous analgesia is important from a fundamental physiological perspective and for identification of novel therapeutic strategies for pain. The endocannabinoid system plays a key role in stres
Publikováno v:
Neurourology and Urodynamics. 38:2112-2120
Aims The goal of this study was to test whether central corticotropin-releasing factor (CRF) was involved in angiotensin II (Ang II) and Ang II type 1 (AT1) receptor-mediated facilitation of micturition reflex and to investigate whether peripherally
Autor:
Kimberley S. Samkoe, Jason R. Gunn, Sally M. Hull, Ana Luiza Ribeiro de Souza, Kayla Marra, Brian W. Pogue, Keith D. Paulsen
Publikováno v:
Photochemistry and Photobiology. 94:1167-1171
Since many types of cancers overexpress EGFR, this surface receptor has been used as a target for therapy or diagnosis of malignant disease. Uptake kinetics of EGFR-targeted fluorescent Affibody (ABY-029) were studied with a view toward optimizing ef
Publikováno v:
Synapse. 74
Pharmacological magnetic resonance imaging (phMRI) allows the visualization of brain pharmacological effects of drugs using functional MRI (fMRI). phMRI can help us facilitate central nervous system (CNS) drug development. However, there have been fe
Autor:
Andrea G. Alonso, Cynthia L. Jordan, Laura E. Newman, Kelly M. Dumais, Alexa H. Veenema, S. Marc Breedlove, Remco Bredewold, Nicholas B. Worley, Nicholas J. Hobbs, Tessa C. Gillespie, Jingting C. Yuan
Publikováno v:
Journal of Neuroendocrinology. 31
Oxytocin (OT) often regulates social behaviours in sex-specific ways, and this may be a result of sex differences in the brain OT system. Adult male rats show higher OT receptor (OTR) binding in the posterior bed nucleus of the stria terminalis (pBNS
Publikováno v:
Addict Biol
A growing number of studies suggest therapeutic applications of cannabidiol (CBD), a recently U.S. Food and Drug Administration (FDA)-approved medication for epilepsy, in treatment of many other neuropsychological disorders. However, pharmacological
Publikováno v:
Clinical and Experimental Pharmacology and Physiology. 42:1059-1067
Orexin/hypocretin neurons are located in and around the perifornical hypothalamus. Disinhibition of this area in the anaesthetized preparation evokes cardiorespiratory changes that can be reduced to nearly half or more by systemic Almorexant, a dual
Autor:
Hyun-Woo Kim, Jiyoung Moon, Seog Bae Oh, Al J Beitz, Ho Jae Han, Soon Gu Kwon, Hoon Seong Choi, Sheu Ran Choi, Jang Hern Lee, S. Y. Kang, Dae Hyun Roh, Seo-Yeon Yoon
Publikováno v:
European Journal of Pain. 20:594-606
Background The role of peripheral sigma-1 receptors (Sig-1Rs) in normal nociception and in pathologically induced pain conditions has not been thoroughly investigated. Since there is mounting evidence that Sig-1Rs modulate ischaemia-induced pathologi
Publikováno v:
Neurogastroenterology & Motility. 27:30-39
Background Corticotropin-releasing hormone (CRH) and its receptor 1 (CRH-R1) play an important role in the colonic response to stress. The central nucleus of the amygdala (CeA) is a major extrahypothalamic site that contains a large number of neurons