Zobrazeno 1 - 10
of 304
pro vyhledávání: ''
Autor:
Isamu Okamoto, Tatsuo Ohira, Nobuyuki Yamamoto, Hidehito Horinouchi, Toyoaki Hida, Shinji Atagi, Tatsuro Fukuhara, Miyako Satouchi, Kazuma Kishi, Shunichi Sugawara, Shi Rong Han, Hideo Saka, Victoria Ebiana, Katsuyuki Hotta, Keisuke Aoe, Kazuhiko Nakagawa, Hiroshi Sakai, Hiroaki Okamoto, Kazuo Noguchi, Kaname Nosaki, Atsushi Horiike, Shigeki Umemura, Toshiaki Takahashi, Takayasu Kurata, Nobuyuki Katakami, Akimasa Sekine
Publikováno v:
Cancer Science
Cancer Sci
Cancer Sci
This prespecified subanalysis of the global, randomized controlled phase III KEYNOTE‐024 study of pembrolizumab vs chemotherapy in previously untreated metastatic non‐small‐cell lung cancer without EGFR/ALK alterations and a programmed death li
Autor:
Xiaojing Zhang, Zhiqiang Meng, Shanzhi Gu, Shukui Qin, Zhendong Chen, Xiao Zhang, Linna Wang, Xinni Chen, Jianjun Zou, Ying Liu, Jianping Xiong, Zhenggang Ren
Publikováno v:
International Journal of Cancer. 149:1944-1954
Biliary tract cancer (BTC) is a highly malignant tumor with limited treatment options and poor prognosis. Our study aimed to evaluate camrelizumab plus oxaliplatin-based chemotherapy as first-line therapy for advanced BTC. In this multicenter, open-l
Autor:
Chia Jui Yen, James J. Harding, Stacey A. Cohen, Mehmet Akce, Yin Hsun Feng, Shukui Qin, Wen Tsung Huang, Imane El Dika, Ghassan K. Abou-Alfa, Tim Meyer, Dae Won Lee, Amanda Johnston, John S. Bomalaski, Debashis Sarker, Benjamin R. Tan, Baek Yeol Ryoo, Eileen M. O'Reilly, Yen Yang Chen, Ho Yeong Lim, Ching Liang Ho, Tsai Sheng Yang
Publikováno v:
Cancer. 127:4585-4593
Background Arginine starvation depletes the micronutrients required for DNA synthesis and interferes with both thymidylate synthetase activity and DNA repair pathways in preclinical models of hepatocellular carcinoma (HCC). Pegylated arginine deimina
Autor:
Koichi Takahashi, Naval Daver, Sanam Loghavi, Yesid Alvarado, Rasoul Pourebrahim, Abhishek Maiti, Tapan M. Kadia, Hagop M. Kantarjian, Musa Yilmaz, Nicholas J. Short, Kunhwa Kim, Courtney D. DiNardo, Maro Ohanian, Farhad Ravandi, Koji Sasaki, Marina Konopleva, Ken Furudate, Guilin Tang, Caitlin R. Rausch
Publikováno v:
Cancer. 127:3772-3781
BACKGROUND TP53 mutation (TP53mut ) confers an adverse prognosis in acute myeloid leukemia (AML). Venetoclax with hypomethylating agents is a current standard for older patients; however, recent reports suggest that TP53mut confers resistance to vene
Autor:
Marc De Man, Pascal Pierre, Erik Vanderstraeten, Ghislain Houbiers, Lionel D'Hondt, Jacques Van Der Auwera, Hassan Rezaei Kalantari, Amélie Deleporte, Ahmad Awada, Lieveke Ameye, Alain Hendlisz, Thierry Delaunoit, Stéphanie Laurent, Francesco Sclafani, Bjorn Ghillemijn, Marylene Clausse, Marianne Paesmans, Angelique Covas, Marc Van den Eynde, Frédéric Forget, Philippe Vergauwe, Stéphane Holbrechts
Publikováno v:
Cancer medicine, Vol. 10, no. 13, p. 4366-4374 (2021)
Cancer Medicine, Vol 10, Iss 13, Pp 4366-4374 (2021)
Cancer Medicine
Cancer Medicine, Vol 10, Iss 13, Pp 4366-4374 (2021)
Cancer Medicine
Background While docetaxel/cisplatin/5‐fluorouracil (DCF) outperforms CF in first‐line gastric adenocarcinoma, toxicity remains an issue. Methods This multicenter phase II trial randomized chemonaïve metastatic gastric adenocarcinoma patients to
Autor:
Reiner Sandner, Roland Schnell, Wolfgang Knauf, Mark-Oliver Zahn, TLN-Group, Leonora Houet, Anja Kaiser-Osterhues, Norbert Marschner, Susanne Tech, Michael Koenigsmann, Wolfgang Abenhardt, Christoph Maintz
Publikováno v:
Hematological Oncology
Owing to its heterogeneity and rarity, management of disseminated marginal zone B‐cell lymphoma (MZL) remains largely understudied. We present prospective data on choice of systemic treatment and survival of patients with MZL treated in German rout
Autor:
Yoko Inaguma, Eiichi Ohtsuka, Yukiyoshi Moriuchi, Kazuho Miyashita, Masashi Mizokami, Nobuhiko Yamauchi, Tadahiko Igarashi, Koji Izutsu, Hiroshi Gomyo, Nobuko Kubota, Ryuzo Ueda, Mio Kurata, Yoshiko Inoue, Yoshiko Atsuta, Rika Sakai, Norifumi Tsukamoto, Yoko Ushijima, Kisato Nosaka, Dai Maruyama, Sachiko Suzuki, Toshiki Uchida, Shinichiro Yoshida, Ilseung Choi, Shigeru Kusumoto, Go Yamamoto, Yasuhito Tanaka, Kensuke Kojima, Satoshi Ichikawa, Hideki Tsujimura
Publikováno v:
Cancer Science
We conducted a nationwide retrospective analysis of 116 hepatitis B virus (HBV) surface antigen (HBsAg)‐positive patients with diffuse large B‐cell lymphoma (DLBCL) and 278 HBsAg‐negative patients with DLBCL, as a control cohort, who received r
Autor:
Keigo Makino, Hiroshi Ishii, Akihito Tsuji, Masato Ozaka, Makoto Ueno, Shingo Kobayashi, Manabu Muto, Daisuke Sakai, Yoshito Komatsu, Masafumi Ikeda, Nobumasa Mizuno, Akira Fukutomi, Toshikazu Moriwaki, Yousuke Nakai, Masayuki Furukawa, Takeshi Kajiwara, Akio Katanuma, Chigusa Morizane, Yuji Negoro, Masahiro Tsuda, Satoshi Shimizu, Junji Furuse, Noriko Nemoto
Publikováno v:
Cancer Medicine, Vol 10, Iss 6, Pp 2088-2099 (2021)
Cancer Medicine
Cancer Medicine
Purpose Effective second‐line chemotherapy options are limited in treating advanced biliary tract cancers (BTCs). Resminostat is an oral histone deacetylase inhibitor. Such inhibitors increase sensitivity to fluorouracil, the active form of S‐1.
Autor:
Yusuke Okuma, Yuki Nakagawa, Kazuo Kasahara, Makoto Nishio, Naoko Sueoka-Aragane, Satoshi Watanabe, Haruhiro Saito, Koichi Goto, Kenichi Chikamori, Tomohisa Kawakami
Publikováno v:
Cancer Science
IMpower132 explored the safety and efficacy of atezolizumab plus pemetrexed and platinum‐based chemotherapy as first‐line treatment for advanced non‐small‐cell lung cancer (NSCLC). Key eligibility criteria for the phase 3, open‐label, IMpow
Publikováno v:
Cancer Medicine, Vol 10, Iss 3, Pp 914-922 (2021)
Cancer Medicine
Cancer Medicine
The previous retrospective study suggested that dosing vitamin K may enhance the anticancer action of sorafenib against hepatocellular carcinoma. To confirm it, we performed a phase II, randomized, open‐label study. Patients with hepatocellular car