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Publikováno v:
British Journal of Clinical Pharmacology. 88:2484-2499
Familial Mediterranean fever (FMF) is the most common monogenic autoinflammatory disease and is usually diagnosed in childhood, especially in the first decade of life. Paediatric FMF is characterized by a protean clinical expression and a variable th
Autor:
Manna Zhang, Diliqinna Dilimuzhati, Xiaowen Shao, Shen Qu, Feng Xing, Meili Cai, Qiongjing Zeng, Yuqin Zhang, Xinyu Gao
Publikováno v:
Diabetes, Obesity and Metabolism. 24:312-320
Objectives This study aimed to determine the safety and efficacy of canagliflozin in comparison to metformin in polycystic ovary syndrome (PCOS) patients with insulin resistance (IR). Methods A single center, prospective, randomized open-label (ratio
Autor:
Marco Pavesi, Moisés Mira Flores, Aurea Duran, Josep Gumà, Alessandra Pranzo, Alexis Serikoff, Bernard Rappe, Angus Robinson, Serena Hilman, Benoit Baron, Louis-Marie Dourthe, D. Mott, Steven Joniau, M. Herdman, Stéphane Mallick, Roberto Bordonaro, Maria De Santis, Ugo De Giorgi, Heather Payne
Publikováno v:
International Journal of Cancer. 150:837-846
In randomized clinical trials, the androgen-receptor inhibitor enzalutamide has demonstrated efficacy and safety in metastatic castration-resistant prostate cancer (mCRPC). This study captured efficacy, safety and patient-reported outcomes (PROs) of
Publikováno v:
Journal of Diabetes Investigation, Vol 12, Iss 11, Pp 1983-1991 (2021)
Journal of Diabetes Investigation
Journal of Diabetes Investigation
Aims/Introduction To evaluate and compare the efficacy of insulin degludec (IDeg) and insulin glargine 300 U/mL (Gla300) 6 months after switching from other basal insulins by assessing the changes in glycated hemoglobin (HbA1c), body mass index (BMI)
Autor:
Kimiyo Raymond, William Brucker, Anna N. Ligezka, Austin Larson, David Cassiman, Devin Oglesbee, Tamas Kozicz, Kishore Garapati, Renee M. McGovern, Ethan O. Perlstein, Wasantha Ranatunga, Christina Lam, Silvia Radenkovic, Mayank Saraswat, Joel M. Reid, Graeme Preston, Karthik Muthusamy, Christin Johnsen, Andrew C. Edmondson, Wirginia Krzysciak, Bart Ghesquière, Eva Morava, Saadet Mercimek-Andrews, Hitoshi Yanaihara, Akhilesh Pandey, Peter Witters
Publikováno v:
Ann Neurol
OBJECTIVE: Epalrestat, an aldose reductase inhibitor increases phosphomannomutase (PMM) enzyme activity in a PMM2-congenital disorders of glycosylation (CDG) worm model. Epalrestat also decreases sorbitol level in diabetic neuropathy. We evaluated th
Publikováno v:
Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy. 41:998-1008
BACKGROUND Mineralocorticoid receptor antagonist (MRA) when combined with either angiotensin-converting enzyme inhibitors (ACEIs) or angiotensin receptor blockers (ARBs) may provide additional benefits of cardiovascular and kidney disease risk reduct
Autor:
Thomas P. Lodise, Monique R Bidell
Publikováno v:
Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy. 41:915-931
Oral tetracyclines have been used in clinical practice for over 60 years. One of the most common indications for use of oral tetracyclines is for treatment of adult outpatients with skin and soft infections (SSTIs), including acute bacterial skin and
Autor:
Steve Vucic, Merrilee Needham, Robert D. Henderson, Matthew C. Kiernan, David Schultz, Susan Mathers
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 8, Iss 10, Pp 1991-1999 (2021)
Annals of Clinical and Translational Neurology
Annals of Clinical and Translational Neurology
Objective Neuroinflammation is an important pathogenic mechanism in amyotrophic lateral sclerosis (ALS), with regulatory T cells (Tregs) mediating a slower rate of disease progression. Dimethyl fumarate enhances Treg levels and suppresses pro-inflamm
Autor:
Daria Piacentino, Olli Kärkkäinen, Lorenzo Leggio, Anton Klåvus, Shelley N. Jackson, Sara L. Deschaine, Kelly M. Abshire, Marko Lehtonen, Seppo Auriola, Mehdi Farokhnia
Publikováno v:
Alcohol Clin Exp Res
BACKGROUND: Ghrelin may influence several alcohol-related behaviors in animals and humans by modulating central and/or peripheral biological pathways. The aim of this exploratory analysis was to investigate associations between ghrelin administration
Autor:
Pankaj Jorwal, Surabhi Vyas, Sanjeev Sinha, Puneet Khanna, Animesh Ray, Immaculata Xess, Satish Swain, Naveet Wig, Radhika Sarda, Anjan Trikha, Gagandeep Singh, Parul Kodan
Publikováno v:
Mycoses
Background Though invasive pulmonary aspergillosis is a well known complication of COVID‐19 pneumonia, indolent forms of aspergillosis have been rarely described. Methods We prospectively collected the clinico‐radio‐microbiological data of 10 p