Zobrazeno 1 - 10
of 249
pro vyhledávání: ''
Autor:
Thomas P. Lodise, Monique R Bidell
Publikováno v:
Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy. 41:915-931
Oral tetracyclines have been used in clinical practice for over 60 years. One of the most common indications for use of oral tetracyclines is for treatment of adult outpatients with skin and soft infections (SSTIs), including acute bacterial skin and
Publikováno v:
Clinical Pharmacology in Drug Development
Pharmacokinetics, safety, and tolerability of abacavir 600 mg/dolutegravir 50 mg/lamivudine 300 mg were assessed in this phase 1, single‐arm, open‐label, single‐dose study in fasted healthy male (n = 4) and female (n = 8) participants of Japane
Publikováno v:
Drug Testing and Analysis
This article reports the results obtained from the investigation of the influence of miconazole administration on the physiological fluctuation of the markers of the steroid profile included in the “steroidal module” of the Athlete Biological Pas
Autor:
Shingen Misaka, Masahiko Suzuki, Yuko Ono, Yayoi Shikama, Tomoyuki Ono, Kenju Shimomura, Hiroshi Ogata, Atsushi Uchida, Hideyuki Sato, Osamu Abe, Satomi Onoue
Publikováno v:
Clinical and Translational Science, Vol 14, Iss 2, Pp 476-480 (2021)
Clinical and Translational Science
Clinical and Translational Science
Lisinopril, a highly hydrophilic long‐acting angiotensin‐converting enzyme inhibitor, is frequently prescribed for the treatment of hypertension and congestive heart failure. Green tea consumption may reduce the risk of cardiovascular outcomes an
Autor:
Keigo Makino, Hiroshi Ishii, Akihito Tsuji, Masato Ozaka, Makoto Ueno, Shingo Kobayashi, Manabu Muto, Daisuke Sakai, Yoshito Komatsu, Masafumi Ikeda, Nobumasa Mizuno, Akira Fukutomi, Toshikazu Moriwaki, Yousuke Nakai, Masayuki Furukawa, Takeshi Kajiwara, Akio Katanuma, Chigusa Morizane, Yuji Negoro, Masahiro Tsuda, Satoshi Shimizu, Junji Furuse, Noriko Nemoto
Publikováno v:
Cancer Medicine, Vol 10, Iss 6, Pp 2088-2099 (2021)
Cancer Medicine
Cancer Medicine
Purpose Effective second‐line chemotherapy options are limited in treating advanced biliary tract cancers (BTCs). Resminostat is an oral histone deacetylase inhibitor. Such inhibitors increase sensitivity to fluorouracil, the active form of S‐1.
Autor:
Pedro Eduardo Fröehlich, Flavio Pechanksy, Graciela Carlos, Fabiano Barreto, Renata Pereira Limberger, Eloisa Comiran
Publikováno v:
Biopharmaceutics & Drug Disposition. 42:3-11
Lisdexamfetamine (LDX) is a long-acting prodrug stimulant indicated for the treatment of attention-deficit/hyperactivity disorder (ADHD) and binge-eating disorder (BED) symptoms. In vivo hydrolysis of the LDX amide bond releases the therapeutically a
Stereoselective Steady‐State Disposition and Bioequivalence of Brand and Generic Bupropion in Adults
Autor:
Evan D. Kharasch, Kristin Kraus, Jane Blood, J. Philip Miller, Eric J. Lenze, Alicia Neiner, Angela Stevens
Publikováno v:
Clinical Pharmacology & Therapeutics. 108:1036-1048
The antidepressant bupropion is stereoselectively metabolized and metabolite enantiomers have differential pharmacologic effects, but steady-state enantiomeric disposition is unknown. Controversy persists about bupropion XL300mg generic equivalence t
Autor:
Francesco Botrè, Loredana Iannella, Xavier de la Torre, Cristiana Colamonici, Chiara Ciccarelli, Davide Curcio, Monica Mazzarino
Publikováno v:
Drug Testing and Analysis. 12:1587-1598
Twenty-two pharmaceutical formulations containing prednisolone or prednisone commercially available in Italy, Belgium, Spain, Brazil, and India were analyzed through a specific gas chromatography combustion isotope ratio mass spectrometry (GC-C-IRMS)
Publikováno v:
The Journal of Clinical Pharmacology. 60:1314-1323
The effects of itraconazole on the pharmacokinetics of rovatirelin were investigated in an open-label, single-sequence drug-drug interaction study in 16 healthy subjects. Subjects were administered a single oral dose of rovatirelin (1.6 mg) on day 1
Autor:
Sean Hennessy, Todd E.H. Hecht, Warren B. Bilker, Stephen E. Kimmel, Meijia Zhou, Colleen M. Brensinger, Charles E. Leonard
Publikováno v:
Clin Pharmacol Ther
Drug-drug interactions (DDIs) with oral anticoagulants may lead to under-anticoagulation and increased risk of thromboembolism. Although warfarin is susceptible to numerous DDIs, few studies have examined DDIs resulting in thromboembolism or those in