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Autor:
Daneng Li, Nicolas Sommer, Wendy Verret, Riad Salem, Riccardo Lencioni, Sairy Hernandez, Beiying Ding
Publikováno v:
Cancer Medicine, Vol 10, Iss 16, Pp 5437-5447 (2021)
Cancer Medicine
Cancer Medicine
Background IMbrave150 is a phase III trial that assessed atezolizumab + bevacizumab (ATEZO/BEV) versus sorafenib (SOR) in patients with unresectable hepatocellular carcinoma (HCC) and demonstrated a significant improvement in clinical outcomes. Explo
Autor:
Michal Sýkora, Lukas Stejskal, Alexandra Jungova, Vladimir Maisnar, Petr Kessler, Viera Sandecká, Jana Ullrychova, Adriana Heindorfer, Luděk Pour, Tomas Pika, Jan Straub, Martin Stork, Jiří Minařík, Lucie Brožová, Roman Hájek, Ivan Spicka, Tomas Jelinek, Petr Pavlicek, David Starostka, Sabina Ševčíková, Jakub Radocha, Marek Wrobel
Publikováno v:
European Journal of Haematology. 107:466-474
Objectives This study compared the use of bortezomib in different combination regimens in newly diagnosed multiple myeloma (NDMM) patients who were transplant ineligible. Patients and methods We analyzed data from the Registry of Monoclonal Gammopath
Autor:
Mathurin Fumery, Jérôme Filippi, Vered Abitbol, Amélie Biron, David Laharie, Melanie Serrero, Romain Altwegg, Yoram Bouhnik, Laurent Peyrin‐Biroulet, Cyrielle Gilletta, Xavier Roblin, Guillaume Pineton de Chambrun, Lucine Vuitton, Anne Bourrier, Stephane Nancey, Jean‐Marc Gornet, Stephane Nahon, Guillaume Bouguen, Stephanie Viennot, Maria Nachury, Aurelien Amiot, Franck Brazier, Clara Yzet, Xavier Hebuterne, Guillaume Cadiot, Hedia Brixi, Pauline Rivière, Florian Poullenot, Xavier Treton, Carmen Stefanescu, Camille Zallot, Laurent Beaugerie, Philippe Seksik, Harry Sokol, Julien Kirchgesner, Gilles Boschetti, Bernard Flourié, Claire Gay, Pauline Danion, Chloe Venturin, Matthieu Allez, Clotilde Baudry, Benjamin Pariente, Pauline Wils, Charlotte Gagnière, Jenny Tannoury
Publikováno v:
Alimentary Pharmacology and Therapeuthics
Alimentary Pharmacology and Therapeuthics, 2021, 54 (7), pp.944-951. ⟨10.1111/apt.16544⟩
Alimentary Pharmacology and Therapeuthics, 2021, 54 (7), pp.944-951. ⟨10.1111/apt.16544⟩
International audience; Background Phase III trials have demonstrated the efficacy and safety of ustekinumab in ulcerative colitis (UC), but few real-life long-term data are currently available. Aims To assess the real-world effectiveness and safety
Autor:
Keita Kudo, Tomomi Masuda, Toshiyuki Harada, Kazuhiro Usui, Eiki Kikuchi, Yukihiro Hasegawa, Akira Inoue, Satoshi Oizimi, Atsushi Nakamura, Makoto Maemondo, Tatsuro Fukuhara, Yuka Fujita, Ryoichi Honda, Hiroshi Yokouchi, Hiroshi Watanabe, Naomi Watanabe, Hisashi Tanaka, Ryota Saito, Naoto Morikawa, Yasutaka Kawai
Publikováno v:
Thoracic Cancer, Vol 12, Iss 14, Pp 2113-2121 (2021)
Thoracic Cancer
Thoracic Cancer
Background A cisplatin plus irinotecan (CPT‐11) regimen is used for patients with extensive disease small cell lung cancer (ED‐SCLC). Amrubicin (AMR) is primarily used for relapsed SCLC. The HOT1401/NJLCG1401 trial, an open‐label randomized pha
Autor:
Nirav Patil, Ankit Mangla, Asrar Alahmadi, Nelroy Jones, Richard T. Lee, David L. Bajor, Jill S. Barnholtz-Sloan, Eva Selfridge, Amr Mohamed, Gino Cioffi, Aman Opneja, Tin-Yun Tang, Joel N. Saltzman
Publikováno v:
Cancer Medicine, Vol 10, Iss 13, Pp 4397-4404 (2021)
Cancer Medicine
Cancer Medicine
Background This study analyzes the pattern of use of single agent anticancer therapy (SAACT) in the treatment and survival of advanced hepatocellular carcinoma (aHCC) before and after sorafenib was FDA approved in 2007. Methods Adult patients diagnos
Autor:
Amit Joshi, Mrudula Patil, Parsshava Mehta, Vijay Patil, Vikram Gota, Bharati Shriyan, Murari Gurjar, Manjunath Nookala, Kumar Prabhash, Vanita Noronha, Anand P. Patil
Publikováno v:
Cancer Medicine, Vol 10, Iss 14, Pp 4948-4956 (2021)
Cancer Medicine
Cancer Medicine
Background Pharmacokinetics (PK) of docetaxel is characterized by high inter‐individual variability (IIV). While covariate models that explain the PK variability of docetaxel exist, not much is known about the effects of genetic variations on docet
Autor:
Yanhong Zhang, Yi Huang, Shaoxiang Xian, Jiaqi Jin, Yang Chen, Dawei Lian, Jiaying Liu, Ruifang Han, Xiao Wang, Li Zhu
Publikováno v:
Journal of Cellular and Molecular Medicine
In diabetes‐induced complications, inflammatory‐mediated endothelial dysfunction is the core of disease progression. Evidence shows that kakonein, an isoflavone common in Pueraria, can effectively treat diabetes and its complications. Therefore,
Publikováno v:
Clinical Pharmacology & Therapeutics. 110:1011-1017
Polypharmacy is common among patients taking prescription opioids long-term, and the codispensing of interacting medications may further increase opioid overdose risk. To identify nonopioid medications that may increase opioid overdose risk in this p
Autor:
Dian Liu, Mengying Suo, Fengshuang An, Xuyang Wang, Ming Liu, Mingjun Zhang, Tao Jin, Jinyu Pan, Jingjing Tian
Publikováno v:
Journal of Cellular and Molecular Medicine
Diabetic cardiomyopathy (DCM) is one of the leading causes of heart failure in patients with diabetes mellitus, with limited effective treatments. The cardioprotective effects of sodium‐glucose cotransporter 2(SGLT2) inhibitors have been supported
Publikováno v:
The Journal of Dermatology. 48:1574-1578
Acral persistent papular mucinosis is a rare subtype of localized lichen myxedematosus. We report a case of a 41-year-old woman with acral persistent papular mucinosis. She had a 5-year history of multiple, scattered, whitish papules, on the back of