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Autor:
Shahin Shadnia, Mohammad-Reza Rouini, Mehri Bemani Naeini, Mahnaz Ahmadimanesh, Mahmoud Ghazi-Khansari
Publikováno v:
Drug Metabolism and Personalized Therapy.
Objectives Due to lack of adequate data on tramadol kinetic in relevance of CYP2D6 toxicity, this study was designed to investigate the effect of CYP2D6 phenotype in tramadol poisoning. The saliva, urine and blood samples were taken at the admission
Publikováno v:
Drug Metabolism and Personalized Therapy. 34
Background Cytochrome P450s (CYPs, EC 1.14.14.1) are the main enzymes of drug metabolism. The functional significance of CYPs also includes the metabolism of foreign chemicals and endogenic biologically active compounds. The CYP3A4 isoform contribute
Autor:
Bonnie S. Coats, Peter W. Stacpoole, Jonathan J. Shuster, Albert L. Shroads, Taimour Y. Langaee
Publikováno v:
Drug Metabolism and Personalized Therapy. 30
Background Chloral hydrate (CH), a sedative and metabolite of the environmental contaminant trichloroethylene, is metabolized to trichloroacetic acid, trichloroethanol, and possibly dichloroacetate (DCA). DCA is further metabolized by glutathione tra
Publikováno v:
Drug Metabolism and Drug Interactions. 26
BACKGROUND The present study was designed as an open label, multiple-dose, randomized, parallel trial to evaluate the pharmacodynamic drug-drug interaction of lisinopril and concomitantly administered diclofenac sodium in non-diabetic and diabetic, m
Publikováno v:
Drug Metabolism and Drug Interactions. 24
Aim To evaluate the drug interactions between valproic acid (VPA) and carbapenem antibiotics. Methods The effects of concurrent use of VPA and carbapenem antibiotics were evaluated in a retrospective observational study of hospitalized adults. Patien
Autor:
Nathan J. Cherrington, Andrew D. Wallace, Matthew K. Ross, Ernest Hodgson, Timothy M Streit, Parikshit C. Das, Yan Cao, Randy L. Rose
Publikováno v:
Drug Metabolism and Drug Interactions. 23
Deltamethrin [(S)-alpha-cyano-3-phenoxybenzyl-cis-(1 R,3R)-3(2,2-dibromovinyl)(2,2-dimethyl-cyclopropane-carboxylate] and permethrin [3-phenoxybenzyl(1RS)-cis,trans-3-(2,2-dichlorovinyl)-2,2-dimethyl-cyclopropanecarboxylate] are pyrethroid insecticid
Publikováno v:
Drug Metabolism and Drug Interactions. 13
Urine (0-24 h) was collected from five subjects on separate occasions following the ingestion of paracetamol at five different dose levels (500, 750, 1000, 1250, 1500 mg) which spanned the normal therapeutic range. The major urinary metabolites were