Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Zylka, Mark J."'
Autor:
Pinckney, Lennisha, Zylka, Mark J., Paul, Ketema N., Jones, Kelly A., Gray, Cloe L., Ehlen, J. Christopher, Philpot, Benjamin D., Brager, Allison J., DeBruyne, Jason P., Burette, Susan, Weinberg, Richard J., Evans, Jennifer A.
Individuals with Angelman syndrome (AS) suffer sleep disturbances that severely impair quality of life. Whether these disturbances arise from sleep or circadian clock dysfunction is currently unknown. Here, we explored the mechanistic basis for these
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ab392245f5af581004add44465271176
Coordination of membrane deformation and cytoskeletal dynamics lies at the heart of many biological processes critical for cell polarity, motility and morphogenesis. We have recently shown that Slit-Robo GTPase-activating protein 2 (srGAP2) regulates
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0a76e4cf4d4e61950f5c4eeaa4a2bbfc
Autor:
Korboukh, Ilia, Zylka, Mark J., Hull-Ryde, Emily A., Frye, Stephen V., Janzen, William P., Rittiner, Joseph E., Jin, Jian
Numerous receptors for ATP, ADP, and adenosine exist; however, it is currently unknown whether a receptor for the related nucleotide adenosine 5′-monophosphate (AMP) exists. Using a novel cell-based assay to visualize adenosine receptor activation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::54b58781a1c03b1f052fd3fdc51c073d
Autor:
Korboukh, Ilia, Setola, Vincent, Randhawa, Amarjit S., Frye, Stephen V., Jin, Jian, Coleman, Jennifer, Janzen, William P., Fitzpatrick, Brendan J., Rittiner, Joseph E., Zylka, Mark J., Hull-Ryde, Emily A.
Adenosine A1 receptor (A1AR) agonists have antinociceptive effects in multiple preclinical models of acute and chronic pain. Although numerous A1AR agonists have been developed, clinical applications of these agents have been hampered by their cardio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5aaa012ad9ed7d0648a1f7a9956a35d5
Autor:
Zylka, Mark J., Taylor-Blake, Bonnie
Thiamine monophosphatase (TMPase, also known as Fluoride-resistant acid phosphatase or FRAP) is a classic histochemical marker of small- to medium-diameter dorsal root ganglia (DRG) neurons and has primarily been studied in the rat. Previously, we fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c7570b6931d0231c23c6a5f94e9cd032
Autor:
Zylka, Mark J., Pearson, Brandon L., Fragola, Giulia, McCoy, Eric S., Simon, Jeremy M., Salazar, Gabriela
Environmental factors, including pesticides, have been linked to autism and neurodegeneration risk using retrospective epidemiological studies. Here we sought to prospectively identify chemicals that share transcriptomic signatures with neurological
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::214f44095e075c80431d3023ee810d45
Prostatic acid phosphatase (PAP) is expressed in nociceptive neurons and functions as an ectonucleotidase. When injected intraspinally, the secretory isoforms of human and bovine PAP protein have potent and long-lasting antinociceptive effects that a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6120b5a7670e3512bfed99d7e6c6c903
Autor:
Twomey, Margaret A., Sowa, Nathaniel A., Taylor-Blake, Bonnie, Voikar, Vootele, Herrala, Annakaisa, Zylka, Mark J., Vihko, Pirkko
Thiamine monophosphatase (TMPase, also known as Fluoride-Resistant Acid Phosphatase) is a classic histochemical marker of small-diameter dorsal root ganglia neurons. The molecular identity of TMPase is currently unknown. We found that TMPase is ident
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e25ff9da68632452d202ab63fa5a796f
Autor:
Zylka, Mark J., Pribisko, Alaine L., Zheng, Jihong, Street, Sarah E., Taylor-Blake, Bonnie, McCoy, Eric S.
Calcitonin gene-related peptide (CGRP) is a classic molecular marker of peptidergic primary somatosensory neurons. Despite years of research, it is unknown if these neurons are required to sense pain or other sensory stimuli. Here, we found that gene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::03fcddb61c4e41dc6bebc8248c467079
Autor:
Bridges, Arlene S., Miriyala, Jayalakshmi, Huang, Hsien-Sung, Philpot, Benjamin D., Dutton, J. Walter, Chen, Xin, Taylor-Blake, Bonnie, Roth, Bryan L., Zylka, Mark J., Jin, Jian, Lee, Hyeong-Min, King, Ian F., Mabb, Angela M., Sciaky, Noah, Allen, John A.
Angelman syndrome is a severe neurodevelopmental disorder caused by deletion or mutation of the maternal allele of the ubiquitin protein ligase E3A (Ube3a)1–3. In neurons, the paternal allele of Ube3a is intact but epigenetically silenced4–6, rai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f511c8031fceb14d3e1879e49c4e2255