Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Timothy J. Mitchison"'
Publikováno v:
Open Biology, Vol 7, Iss 11 (2017)
Open Biology
Open Biology
Paclitaxel is a successful anti-cancer drug that kills cancer cells in two-dimensional culture through perturbation of mitosis, but whether it causes tumour regression by anti-mitotic actions is controversial. Drug candidates that specifically target
Autor:
Timothy J. Mitchison
Publikováno v:
Philosophical Transactions of the Royal Society B: Biological Sciences. 360:623-629
In Xenopus extract meiotic spindles, microtubules slide continuously towards their minus ends, a process called poleward flux. This article discusses recent progress in determining the mechanism of poleward flux, and its functions in spindle organiza
Autor:
Timothy J. Mitchison
Publikováno v:
Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences. 349:299-304
Actin filaments and microtubules form the cytoskeleton of all eukaryotic cells, and they are responsible for organizing the cytoplasm and supporting motile processes. Both polymers are highly dynamic, and their polymerization dynamics are central to
Autor:
Timothy J. Mitchison
Publikováno v:
Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences. 336:99-106
Microtubules and actin filaments are organized into dynamic arrays inside cells. In this paper I discuss in conceptual form the assembly mechanisms of three specific arrays: asters, spindles and leading edge structures. The role of energy transducing