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Autor:
Mario De Marchi, Franca Gerosa, Angela Robbiano, Marco Astegiano, Robert A. Kastelein, Semih Esin, Lyudmila A. Lyakh, Daniela Giachino, Barbara Baldani-Guerra, Maria Rita Consolaro, Robin T. Winkler-Pickett, Giovanna Batoni, A. Sambataro, Giuseppe Carra, Giorgio Trinchieri
Publikováno v:
The Journal of Experimental Medicine
We analyzed interleukin (IL) 12 and IL-23 production by monocyte-derived dendritic cells (mono-DCs). Mycobacterium tuberculosis H37Rv and zymosan preferentially induced IL-23. IL-23 but not IL-12 was efficiently induced by the combination of nucleoti
Autor:
Karen L. Elkins, Siobhán C. Cowley
Publikováno v:
The Journal of Experimental Medicine
A variety of data suggest that in vivo production of interferon (IFN)-gamma is necessary, but not sufficient, for expression of secondary protective immunity against intracellular pathogens. To discover specific IFN-gamma-independent T cell mediated
Autor:
Thais P. Salazar-Mather, Lene Malmgaard, Giorgio Trinchieri, Carine Asselin-Paturel, Marc Dalod, Christine A. Biron, Francine Brière, Casey A. Lewis
Publikováno v:
The Journal of Experimental Medicine
Interferon (IFN)-α/β and interleukin (IL)-12 are cytokines critical in defense against viruses, but their cellular sources and mechanisms of regulation for in vivo expression remain poorly characterized. The studies presented here identified a nove
Publikováno v:
The Journal of Experimental Medicine
We have previously shown that the obligate intracellular pathogen chlamydia can suppress interferon (IFN)-γ–inducible major histocompatibility complex (MHC) class II expression in infected cells by degrading upstream stimulation factor (USF)-1. We
Autor:
J.C. Olivo, G. Tran Van Nhieu, Guillaume Duménil, Marc Fellous, Philippe J. Sansonetti, Sandra Pellegrini
Publikováno v:
The Journal of Cell Biology
Shigella flexneri, the causative agent of bacillary dysentery, has the ability to enter nonphagocytic cells. The interferon (IFN) family of cytokines was found to inhibit Shigella invasion of cultured epithelial cells. We show here that IFN-alpha inh
Autor:
D Santoli, G Trinchieri
Publikováno v:
The Journal of Experimental Medicine
Interferon, induced in lymphocytes either with viruses or cell lines, increases severalfold the natural cytotoxicity of human lymphocytes on target cell lines. Cell separation experiments support the hypothesis that interferon enhances the activity o
Publikováno v:
The Journal of Cell Biology
Interferons have been postulated to participate in growth regulation of normal body tissues and are known to inhibit growth of human epidermal keratinocytes in vitro. Polyclonal antibodies to recombinant human interferon-alpha, purified by passage ov