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Autor:
Tatsuro Katsuno, Ifor R. Williams, Tomoo Nakagawa, Toshihiko Iwanaga, Naoko Tachibana, Hiroshi Ohno, Toshiro Sato, Toshi Jinnohara, Shinya Hidano, Takashi Kanaya, Shunsuke Kimura, Taishin Akiyama, Sayuri Sakakibara, Takashi Kobayashi, Masami Hachisuka, Naoya Kato
Publikováno v:
The Journal of Experimental Medicine
TRAF6 is essential for RANK-mediated NF-κB activation and is involved in the development of several types of cells. Kanaya et al. demonstrate that RANK–TRAF6-mediated NF-κB is essential for the development of M cells and FAE.
M cells are loc
M cells are loc
Autor:
Elaine Fuchs, Evan Heller
Publikováno v:
The Journal of Cell Biology
In development, cells organize into biological tissues through cell growth, migration, and differentiation. Globally, this process is dictated by a genetically encoded program in which secreted morphogens and cell–cell interactions prompt the adopt
Publikováno v:
The Journal of Cell Biology
The luminal domain of Nup210 that lacks NPC sorting signals is sufficient for myogenesis, which suggests that Nup210 may operate within the nuclear envelope/ER lumen during differentiation.
Previously, we identified the nucleoporin gp210/Nup210
Previously, we identified the nucleoporin gp210/Nup210
Autor:
Yichuan Xiao, Zuliang Jie, Jin Jin, James Y. H. Li, Hongbo Hu, Qiang Zou, Xiaofei Zhou, Shao Cong Sun, Xiaoping Xie, Xuhong Cheng
Publikováno v:
The Journal of Experimental Medicine
Zou et al. identify a Golgi-associated factor, TRAF3-interacting protein 3 (TRAF3IP3), as a crucial mediator of thymocyte development regulating TCR-stimulated ERK signaling in the Golgi.
Generation of T lymphocytes in the thymus is guided by si
Generation of T lymphocytes in the thymus is guided by si
Autor:
Louis Antonelli, Elisa Cesarini, Alice Cortesi, Gennaro Oliva, Chiara Mozzetta, Beatrice Bodega, Simona Di Pelino, Francesco Gregoretti, Chiara Lanzuolo, Fabrizia Marullo, Stefano Squarzoni, Marta Columbaro, Alessio Zippo, Daniela Palacios, Annagiusi Gargiulo
Publikováno v:
The Journal of Cell Biology
The Journal of cell biology 211 (2015): 533–551. doi:10.1083/jcb.201504035
info:cnr-pdr/source/autori:Elisa Cesarini, Chiara Mozzetta, Fabrizia Marullo, Francesco Gregoretti, Annagiusi Gargiulo, Marta Columbaro, Alice Cortesi, Laura Antonelli, Simona Di Pelino, Stefano Squarzoni, Daniela Palacios, Alessio Zippo, Beatrice Bodega, Gennaro Oliva and Chiara Lanzuolo/titolo:Lamin A%2FC sustains PcG proteins architecture maintaining transcriptional repression at target genes/doi:10.1083%2Fjcb.201504035/rivista:The Journal of cell biology/anno:2015/pagina_da:533/pagina_a:551/intervallo_pagine:533–551/volume:211
The Journal of cell biology 211 (2015): 533–551. doi:10.1083/jcb.201504035
info:cnr-pdr/source/autori:Elisa Cesarini, Chiara Mozzetta, Fabrizia Marullo, Francesco Gregoretti, Annagiusi Gargiulo, Marta Columbaro, Alice Cortesi, Laura Antonelli, Simona Di Pelino, Stefano Squarzoni, Daniela Palacios, Alessio Zippo, Beatrice Bodega, Gennaro Oliva and Chiara Lanzuolo/titolo:Lamin A%2FC sustains PcG proteins architecture maintaining transcriptional repression at target genes/doi:10.1083%2Fjcb.201504035/rivista:The Journal of cell biology/anno:2015/pagina_da:533/pagina_a:551/intervallo_pagine:533–551/volume:211
Reduction of lamin A/C, which is evolutionarily required for the modulation of Polycomb group (PcG) protein–dependent transcriptional repression by sustaining PcG protein nuclear architecture, leads to PcG protein diffusion and to muscle differenti
Autor:
Naotomo Kambe, Kazutaka Ikeda, Hiroki Nakanishi, Yoshimi Miki, Kei Yamamoto, Yasumasa Nishito, Kazuaki Muramatsu, Kenji Kabashima, Gérard Lambeau, Mariko Sato, Yoshitaka Taketomi, Ryo Taguchi, Makoto Murakami, Choji Taya, Michael H. Gelb
Publikováno v:
The Journal of Experimental Medicine
Yamamoto et al. report that PLA2G2F represents a previously unrecognized regulator of skin pathophysiology, and point to this enzyme as a novel drug target for epidermal-hyperplasic diseases.
Epidermal lipids are important for skin homeostasis.
Epidermal lipids are important for skin homeostasis.
Publikováno v:
The Journal of Cell Biology
Epithelial cells from diverse tissues, including the enterocytes that line the intestinal tract, remodel their apical surface during differentiation to form a brush border: an array of actin-supported membrane protrusions known as microvilli that inc
Autor:
Dean Sheppard, David J. Erle
Publikováno v:
The Journal of Cell Biology
The clinical manifestations of asthma are caused by obstruction of the conducting airways of the lung. Two airway cell types are critical for asthma pathogenesis: epithelial cells and smooth muscle cells. Airway epithelial cells, which are the first
Autor:
Srimoyee Ghosh, Jose M. Lora, Andres Salmeron, Hon-Ren Huang, Deanna A. Mele, Barbara M. Bryant
Publikováno v:
The Journal of Experimental Medicine
The BET family of chromatin adaptors promotes TH17 differentiation, and inhibition of BET proteins protects against autoimmune diseases, including collagen-induced arthritis and EAE, in mice.
Interleukin (IL) 17–producing T helper (TH17) cells
Interleukin (IL) 17–producing T helper (TH17) cells
Autor:
Daniel Graf, Johannes Stöckl, Maria Seyerl, Madhura Modak, René Köffel, Herbert Strobl, Christopher Schuster, Karin Wagner, Nighat Yasmin, Adelheid Elbe-Bürger, Thomas Bauer
Publikováno v:
The Journal of Experimental Medicine
Bone morphogenetic protein 7 (BMP7) promotes the differentiation of Langerhans cells in the epidermis during prenatal development.
Human Langerhans cell (LC) precursors populate the epidermis early during prenatal development and thereafter unde
Human Langerhans cell (LC) precursors populate the epidermis early during prenatal development and thereafter unde