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Autor:
Emily M. Hatch, Martin W. Hetzer
Publikováno v:
The Journal of Cell Biology
Hatch and Hetzer show that nuclear envelope rupture in cancer cells is caused by defects in lamina organization, resulting in an increase in intranuclear pressure from actin-based nucleus confinement.
Repeated rounds of nuclear envelope (NE) rup
Repeated rounds of nuclear envelope (NE) rup
Autor:
Carmen A. Ufret-Vincenty, Marcus D. Collins, Mario G. Rosasco, Gilbert Q. Martinez, Rebecca M. Klein, Sharona E. Gordon
Publikováno v:
The Journal of General Physiology
Phosphoinositides bind to a selective site in the proximal C-terminal region to regulate TRPV1.
Although PI(4,5)P2 is believed to play an essential role in regulating the activity of numerous ion channels and transporters, the mechanisms by whic
Although PI(4,5)P2 is believed to play an essential role in regulating the activity of numerous ion channels and transporters, the mechanisms by whic
Autor:
J. Richard McIntosh, Vladimir A. Volkov, Natalie G. Ahn, William M. Old, Kutralanathan Renganathan, P. M. Grissom, Vladimir K. Arzhanik, Anatoly V. Zaytsev, Tristan D. McClure-Begley
Publikováno v:
The Journal of Cell Biology
Both N- and C-terminal microtubule (MT)-binding domains of CENP-F can follow depolymerizing MT ends while bearing a significant load, and the N-terminal domain prefers binding to curled oligomers of tubulin relative to MT walls by approximately fivef
BRCA2 diffuses as oligomeric clusters with RAD51 and changes mobility after DNA damage in live cells
Autor:
Claire Wyman, Marcel Reuter, Erik Meijering, Jeroen Essers, Gijsbert J. van Belle, Martin E. van Royen, Alex N. Zelensky, Adriaan B. Houtsmuller, Wiggert A. van Cappellen, H. Martijn de Gruiter, Roland Kanaar, Ihor Smal
Publikováno v:
The Journal of Cell Biology
Journal of Cell Biology, 207(5), 599-613. Rockefeller University Press
Journal of Cell Biology, 207(5), 599-613. Rockefeller University Press
Nuclear BRCA2 is oligomeric and associated with RAD51, possibly sequestering it until it is delivered to DNA damage sites.
Genome maintenance by homologous recombination depends on coordinating many proteins in time and space to assemble at DNA
Genome maintenance by homologous recombination depends on coordinating many proteins in time and space to assemble at DNA
Autor:
Anatoly V. Zaytsev, Ekaterina L. Grishchuk, Jennifer G. DeLuca, Lynsie J.R. Sundin, Keith F. DeLuca
Publikováno v:
The Journal of Cell Biology
Accurate regulation of kinetochore–microtubule affinity is driven by incremental phosphorylation of an NDC80 molecular “lawn,” in which NDC80–microtubule bonds reorganize dynamically in response to the number and stability of microtubule atta
Autor:
James K. Chen, Karen Mruk
Publikováno v:
The Journal of Cell Biology
Synthetic chemistry has enabled scientists to explore the frontiers of cell biology, limited only by the laws of chemical bonding and reactivity. As we investigate biological questions of increasing complexity, new chemical technologies can provide s
Publikováno v:
The Journal of Cell Biology
Electron microscopy and crystallography studies of α4β7 integrin reveal the mechanism by which this atypical integrin enables rolling adhesion prior to integrin activation.
The lymphocyte homing receptor integrin α4β7 is unusual for its abil
The lymphocyte homing receptor integrin α4β7 is unusual for its abil
Publikováno v:
The Journal of Cell Biology
Interaction between L17 in the ribosome tunnel and folded nascent chain transmembrane segments during multi-spanning membrane protein synthesis triggers structural rearrangements in the ribosome that cause switching between cytosolic and ER lumenal t
Autor:
Bruce L. Goode, Jan Schmoranzer, James B. Moseley, Lynne Cassimeris, Gregg G. Gundersen, Francesca Bartolini
Publikováno v:
The Journal of Cell Biology
A critical microtubule (MT) polarization event in cell migration is the Rho/mDia-dependent stabilization of a subset of MTs oriented toward the direction of migration. Although mDia nucleates actin filaments, it is unclear whether this or a separate
Autor:
Richard Wolfenden
Publikováno v:
The Journal of General Physiology
Roles of Solvent Water in the Positions of Biological Equilibria The noncovalent binding interactions of biological molecules involve the stripping away of solvent water from regions of contact between the binding partners. Accordingly, the net stren