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Autor:
Daniel Graf, Johannes Stöckl, Maria Seyerl, Madhura Modak, René Köffel, Herbert Strobl, Christopher Schuster, Karin Wagner, Nighat Yasmin, Adelheid Elbe-Bürger, Thomas Bauer
Publikováno v:
The Journal of Experimental Medicine
Bone morphogenetic protein 7 (BMP7) promotes the differentiation of Langerhans cells in the epidermis during prenatal development.
Human Langerhans cell (LC) precursors populate the epidermis early during prenatal development and thereafter unde
Human Langerhans cell (LC) precursors populate the epidermis early during prenatal development and thereafter unde
Autor:
Cindy S. Ma, Christoph Klein, Anna Chan, Stéphanie Boisson-Dupuis, Diana Averbuch, Megan L. Ives, Stephen Adelstein, Jean-Laurent Casanova, David A. Fulcher, Dan Engelhard, Peter D. Arkwright, Anne Durandy, Gulbu Uzel, Jane Peake, Masao Kobayashi, Matthew C. Cook, Sharon Choo, Stuart G. Tangye, Danielle T. Avery, Jennifer Stoddard, Martyn A. French, Steven M. Holland, Lucinda J. Berglund, Elissa K. Deenick, Jacinta Bustamante, Melanie Wong, Miyuki Tsumura, Capucine Picard, Joanne Smart, Joachim Roesler, Leen Moens
Publikováno v:
The Journal of Experimental Medicine
Memory B cells, unlike naive B cells, require a reduced level of STAT3 activation to differentiate into antibody-secreting plasmablasts in response to IL-10 and IL-21; however, this process requires IL-21R expression in both naive and memory cells.
Publikováno v:
The Journal of Experimental Medicine
Diminished expression of Blimp-1 in DCs results in the development of lupus-like autoantibodies in female mice, but not male mice, as a result of increased IL-6 driving enhanced germinal center responses.
Blimp-1 has been identified as a key reg
Blimp-1 has been identified as a key reg
Autor:
Katja Mohrs, Jürgen van der Bosch, Helmut L. Haas, Colin M. Fitzsimmons, Michael J. Doenhoff, Markus Mohrs, Bart Everts, Georgia Perona-Wright, Cornelis H. Hokke, Maria Yazdanbakhsh, Alwin J. van der Ham, Gabriele Schramm, Hermelijn H. Smits
Publikováno v:
The Journal of Experimental Medicine
Soluble egg antigens of the parasitic helminth Schistosoma mansoni (S. mansoni egg antigen [SEA]) induce strong Th2 responses both in vitro and in vivo. However, the specific molecules that prime the development of Th2 responses have not been identif
Autor:
Giulia Casorati, Jiri Litzman, Maria Grazia Roncarolo, Teresa Espanol, Paolo Dellabona, Marita Bosticardo, Caterina Cancrini, László Maródi, Ansgar Schulz, Elena Draghici, Anna Villa, Marco Catucci, Francesco Marangoni, Michela Locci, Robbert G. M. Bredius, Adrian J. Thrasher, Alessandro Aiuti
Publikováno v:
The Journal of Experimental Medicine
The Journal of experimental medicine, vol 206, iss 4
The Journal of experimental medicine, vol 206, iss 4
The Wiskott-Aldrich syndrome (WAS) protein (WASp) is a regulator of actin cytoskeleton in hematopoietic cells. Mutations of the WASp gene cause WAS. Although WASp is involved in various immune cell functions, its role in invariant natural killer T (i
Publikováno v:
The Journal of Experimental Medicine
Flt3 ligand (Flt3L) is a nonredundant cytokine in type I interferon-producing cell (IPC) and dendritic cell (DC) development, and IPC and DC differentiation potential is confined to Flt3+ hematopoietic progenitor cells. Here, we show that overexpress
Autor:
Federica Sallusto, Laura Rivino, Jens Geginat, Antonio Lanzavecchia, Mara Messi, David Jarrossay
Publikováno v:
The Journal of Experimental Medicine
We previously reported that central-memory T cells (T(CM) cells), which express lymph node homing receptors CCR7 and CD62L, are largely devoid of effector functions but acquire characteristics of effector-memory T cells (T(EM) cells) (i.e., CCR7(-) T
Publikováno v:
The Journal of Experimental Medicine
Much remains to be learned about the physiologic events that promote monocytes to become lymph-homing dendritic cells (DCs). In a model of transendothelial trafficking, some monocytes become DCs in response to endogenous signals. These DCs migrate ac
Autor:
Edward A. Clark
Publikováno v:
The Journal of Experimental Medicine
After antigen capture, dendritic cells (DC) migrate into T cell-rich areas of secondary lymphoid organs, where they induce T cell activation, that subsequently drives B cell activation. Here, we investigate whether DC, generated in vitro, can directl
Publikováno v:
The Journal of Experimental Medicine
Previous studies have suggested that granulated metrial gland (GMG) cells are bone marrow– derived lymphoid cells, which differentiate in situ in the mouse pregnant uterus into natural killer (NK)–like cells. Similar to NK cells, GMG cells expres